Publications by authors named "Xinyi Hua"

Article Synopsis
  • The study explores the resurgence of Oropouche fever in Brazil from 2023 to 2024, focusing on virological factors influencing the outbreak after decades of sporadic cases.
  • Researchers gathered data from various sources, analyzed serum samples from patients and previously infected individuals, and performed molecular tests to understand the virus's characteristics and behavior.
  • The findings showed an extraordinary spike in cases in 2024, with over 8,600 confirmed incidents, highlighting the virus's widespread distribution across all regions of Brazil.
View Article and Find Full Text PDF
Article Synopsis
  • Western equine encephalitis virus (WEEV) caused a significant outbreak in Argentina and Uruguay from December 2023 to April 2024, with 217 human cases and 2,548 equine cases reported.
  • The investigation focused on the Rio Grande do Sul state border area between Argentina and Uruguay, utilizing epidemiologic, entomological, and genomic methods to analyze the outbreak.
  • A novel lineage of the virus, proposed as lineage C, was identified in three fatal equine cases, emphasizing the need for ongoing monitoring and equine vaccination to prevent future outbreaks.
View Article and Find Full Text PDF
Article Synopsis
  • * The study included data from 2015 to 2024, revealing a dramatic rise in infections—83.2% occurring in the North—and identified a novel OROV strain that is much more virulent than the original prototype.
  • * The new OROV strain was shown to replicate significantly faster and more effectively in mammalian cells, with a notable decrease in neutralizing antibodies from individuals previously infected, indicating a potential threat to public health.
View Article and Find Full Text PDF

Objective: Mathematical models are vital tools to understand transmission dynamics and assess the impact of interventions to mitigate COVID-19. However, historically, their use in Africa has been limited. In this scoping review, we assess how mathematical models were used to study COVID-19 vaccination to potentially inform pandemic planning and response in Africa.

View Article and Find Full Text PDF

We estimated COVID-19 transmission potential and case burden by variant type in Alberta, British Columbia, and Ontario, Canada, during January 23, 2020-January 27, 2022; we also estimated the effectiveness of public health interventions to reduce transmission. We estimated time-varying reproduction number (R) over 7-day sliding windows and nonoverlapping time-windows determined by timing of policy changes. We calculated incidence rate ratios (IRRs) for each variant and compared rates to determine differences in burden among provinces.

View Article and Find Full Text PDF

Bowel dysfunction has been proven to be the most typical complication of long-segment Hirschsprung disease (LSHD). Additionally, bowel dysfunction in preschool and early childhood should be properly assessed, because it may result in persistent bowel dysfunction, social issues, and depression in adolescence and adulthood. This study evaluated bowel function during preschool and early childhood in patients with LSHD.

View Article and Find Full Text PDF

Objective: This study investigates the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission potential in North Dakota, South Dakota, Montana, Wyoming, and Idaho from March 2020 through January 2021.

Methods: Time-varying reproduction numbers, , of a 7-d-sliding-window and of non-overlapping-windows between policy changes were estimated using the instantaneous reproduction number method. Linear regression was performed to evaluate if per-capita cumulative case-count varied across counties with different population size or density.

View Article and Find Full Text PDF

Introduction: We aimed to examine how public health policies influenced the dynamics of coronavirus disease 2019 (COVID-19) time-varying reproductive number ( ) in South Carolina from February 26, 2020, to January 1, 2021.

Methods: COVID-19 case series (March 6, 2020, to January 10, 2021) were shifted by 9 d to approximate the infection date. We analyzed the effects of state and county policies on using EpiEstim.

View Article and Find Full Text PDF

Objectives: To estimate the rate ratio (RR) of reported Coronavirus Disease 2019 (COVID-19) cases among governmental employees from seven District of Columbia (D.C.) departments from March 2020 to February 2022.

View Article and Find Full Text PDF

Purpose: To quantify and compare SARS-CoV-2 transmission potential across Alabama, Louisiana, and Mississippi and selected counties.

Methods: To determine the time-varying reproduction number R of SARS-CoV-2, we applied the R package EpiEstim to the time series of daily incidence of confirmed cases (mid-March 2020 - May 17, 2021) shifted backward by 9 days. Median R percentage change when policies changed was determined.

View Article and Find Full Text PDF

Colombia announced the first case of severe acute respiratory syndrome coronavirus 2 on March 6, 2020. Since then, the country has reported a total of 5,002,387 cases and 127,258 deaths as of October 31, 2021. The aggressive transmission dynamics of SARS-CoV-2 motivate an investigation of COVID-19 at the national and regional levels in Colombia.

View Article and Find Full Text PDF

Purpose: To examine the time-varying reproduction number, R, for COVID-19 in Arkansas and Kentucky and investigate the impact of policies and preventative measures on the variability in R.

Methods: Arkansas and Kentucky county-level COVID-19 cumulative case count data (March 6-November 7, 2020) were obtained. R was estimated using the R package 'EpiEstim', by county, region (Delta, non-Delta, Appalachian, non-Appalachian), and policy measures.

View Article and Find Full Text PDF

Background: Washington, District of Columbia lowered severe acute respiratory syndrome coronavirus 2 transmission in its large jail while community incidence was still high.

Methods: Coordinated clinical and operational interventions brought new cases to near zero.

Results: Aggressive infection control and underlying jail architecture can promote correctional coronavirus disease 2019 management.

View Article and Find Full Text PDF

This study quantifies the transmission potential of SARS-CoV-2 across public health districts in Georgia, USA, and tests if per capita cumulative case count varies across counties. To estimate the time-varying reproduction number, of SARS-CoV-2 in Georgia and its 18 public health districts, we apply the R package 'EpiEstim' to the time series of historical daily incidence of confirmed cases, 2 March-15 December 2020. The epidemic curve is shifted backward by nine days to account for the incubation period and delay to testing.

View Article and Find Full Text PDF

An innovative biosensing assay was developed for simplified, cost-effective, and sensitive detection. By rapid, direct treatment of target proteins with iron porphyrin (TPPFe) , a carboxyl group of amino acid conjugates with an Fe atom of the TPPFe molecule, forming a stable protein complex. We have shown that this complex not only maintains the integrity and functions of original proteins but also acquires peroxidase activity that can turn TMB to a comparably visible signal like that in ELISA.

View Article and Find Full Text PDF

Objective: To systematically analyze the existing intelligent rehabilitation mobile applications (APPs) related to distal radius fracture (DRF) and evaluate their features and characteristics, so as to help doctors and patients to make evidence-based choice for appropriate intelligent-assisted rehabilitation.

Methods: Literatures which in regard to the intelligent rehabilitation tools of DRF were systematic retrieved from the PubMed, the Cochrane library, Wan Fang, and VIP Data. The effective APPs were systematically screened out through the APP markets of iOS and Android mobile platform, and the functional characteristics of different APPs were evaluated and analyzed.

View Article and Find Full Text PDF

Changes in biothiols, including glutathione (GSH) and cysteine, are closely related to a variety of diseases and cellular functions. Real-time monitoring intracellular GSH and cysteine dynamics in living cells are important for understanding pathophysiological processes. In this study, a stable heterostructure of dual-emission fluorescent gold carbon dots (GCDs) consisting of carbon skeleton and gold nanoclusters was prepared, which emits strong blue fluorescence and weak yellow-orange fluorescence.

View Article and Find Full Text PDF

Ferroptosis is an iron-dependent form of regulated cell death. In this study, a ratiometric fluorescent probe, gold carbon dots (GCDs) consisting of carbon skeleton and gold nanoclusters, was used for in situ imaging to monitor redox status in biothiols (glutathione and cysteine) and ferric metabolism of cancer cells in ferroptosis. The as-prepared GCDs can selectively respond to biothiols, interestingly, the fluorescence may be switched to sense ferric ions without interference by biothiols under proper conditions.

View Article and Find Full Text PDF

Long noncoding RNA (lncRNA) B3GALT5-AS1 has been reported as a biomarker for cancer monitoring. This research aims to identify serum long noncoding RNA B3GALT5-AS1 as a new biomarker for the diagnosis of colorectal cancer (CRC) and evaluate its clinical value. Serum B3GALT5-AS1 expression levels were measured by quantitative real-time PCR.

View Article and Find Full Text PDF

Glutathione (GSH) plays a variety of vital functions in biological systems. Growth-associated change of GSH level in cells might be critical for cell survival and monitoring of GSH in living cells are of great significance for understanding the dynamic link between GSH and some diseases. In this work, chitason micelles templated gold nanoclusters (CM-Au NCs) emitting red fluorescence were prepared with a simple and rapid method, which shows interesting phenomenon of aggregation induced emission (AIE) affected by the size of the chitosan micelles.

View Article and Find Full Text PDF

To obtain sensitive analytical detection methods, many unique materials have been developed and made them promising candidates for biosensing. In this study, a type of core-shell gold nanorods, GNR@AuS/AuAgS/CuS, possessing peroxidase-like activity was prepared in a simple, facile manner. A colorimetric strategy for detection of blood glucose, insulin and differentiating type 1 and type 2 diabetes was developed based on the unique GNR@AuS/AuAgS/CuS.

View Article and Find Full Text PDF

The purpose of this study was to understand the influence of Maillard reaction (MR) on bioactivity of chitosan oligosaccharide (COS). The antibacterial activity against Pseudomonas aeruginosa and Vibrio parahaemolyticus and preservative effect of two kinds of COS MR products (MRPs) on Penaeus vannamei were evaluated. The structures of CG (MRPs of COS and glucose) and CM (MRPs of COS and maltose) were characterized by FT-IR and their molecular weights were measured by gel permeation chromatography (GPC).

View Article and Find Full Text PDF