Resveratrol Alleviates the Prenatally Intermittent Hypoxia-Induced Cognitive Impairment in Male Offspring Mice Through Modulating the SIRT1/HIF-1α Pathway.

Objective: Growing evidence indicate that prenatal intermittent hypoxia (PIH) exposure can have an impact on the critical brain nerve development of the fetus, resulting in cognitive deficits in the offspring mice. Resveratrol, recognized for its anti-inflammatory and antioxidant capabilities, has potential to ameliorate synaptic dysfunction, which in turn may contribute to its positive influence on cognitive impairment. Nevertheless, the precise manner in which resveratrol mitigates cognitive deficits stemming from maternal hypoxia remains to be fully elucidated, including the specific mechanisms at play.

Association Between Dietary Alcohol Intake and Migraine or Severe Headache Miscellaneous Pain: The NHANES 1999-2004.

Background: The relationship between alcohol consumption and migraine or severe headache remains controversial in the existing literature. Given that alcohol is a widely consumed beverage, clarifying the relationship between alcohol and migraine or severe headaches can help manage the patient's condition.

Aim: This study aimed to investigate the potential relationship between alcohol consumption and migraine or severe headache.

Molecular Mechanisms Underlying Heart Failure and Their Therapeutic Potential.

Heart failure (HF) is a prominent fatal cardiovascular disorder afflicting 3.4% of the adult population despite the advancement of treatment options. Therefore, a better understanding of the pathogenesis of HF is essential for exploring novel therapeutic strategies.

A metal-polyphenol network-based iron supplement with improved stability and reduced gastrointestinal toxicity for iron deficiency anemia therapy.

Iron deficiency anemia (IDA) is a global health concern, particularly affecting women and children of reproductive age. Although oral iron supplements are the standard treatment for IDA, their bioavailability is often compromised by food interactions, and they are associated with significant gastrointestinal side effects. To overcome these limitations, we developed a novel iron nano-supplement, TA-Fe NPs, based on metal-polyphenol networks (MPNs) formed through the coordination of tannic acid (TA) and Fe.

Shuhe granule for insomnia: study protocol for a double-blind, randomized, placebo-controlled trial.

Introduction: Modern medical treatment of insomnia is often associated with issues like addiction, drug resistance, and a high risk of relapse post drug withdrawal. To tackle these challenges, the Chinese medicine formula Shuhe granule (SHG) has been employed in insomnia treatment at Guangdong Provincial Hospital of Chinese Medicine. Despite this, there is currently a lack of reliable evidence from evidence-based trials to support the widespread use of SHG in insomnia treatment.

Abstract sentence meanings are grounded in the sensory-motor regions in a context-dependent fashion.

Sentences conveying abstract meanings are crucial tools for high-level thinking and communication. Previous research has sparked a debate on whether abstract concepts rely on the representation of the sensory-motor brain areas. We explored this issue with the assumption that abstract meanings at the sentence level could invoke the sensory-motor regions a context-dependent fashion.

Spatial interpolation of cropland soil bulk density by increasing soil samples with filled missing values.

Large sample sizes are crucial for accurately capturing spatial changes in soil properties by spatial interpolation methods. However, soil bulk density (BD) data in historical datasets is often incomplete, and it's uncertain if filled values enhance spatial interpolation accuracy. Using 2,883 cropland soil BD samples from the Sichuan Basin in China, we developed the best prediction models from traditional pedotransfer function (PTF), multiple linear regression (MLR), random forest (RF), and radial basis function neural network (RBFNN) to fill missing BD values for 1,336 samples.

Folate receptor alpha for cancer therapy: an antibody and antibody-drug conjugate target coming of age.

Folate receptor alpha (FRα) has long been the focus of therapeutics development in oncology across several solid tumors, notably ovarian, lung, and subsets of breast cancers. Its multiple roles in cellular metabolism and carcinogenesis and tumor-specific overexpression relative to normal tissues render FRα an attractive target for biological therapies. Here we review the biological significance, expression distribution, and characteristics of FRα as a highly promising and now established therapy target.

Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness.

Psychological stress causes gut microbial dysbiosis and cancer progression, yet how gut microbiota determines psychological stress-induced tumor development remains unclear. Here we showed that psychological stress promotes breast tumor growth and cancer stemness, an outcome that depends on gut microbiota in germ-free and antibiotic-treated mice. Metagenomic and metabolomic analyses revealed that psychological stress markedly alters the composition and abundance of gut microbiota, especially Akkermansia muciniphila (A.

Identification of a conserved cryptic epitope with cross-immunoreactivity in outer membrane protein K (OmpK) from Vibrio species.

Outer membrane protein K (OmpK) has been proven to be an ideal vaccine candidate for broad-spectrum cross-prevention against Vibriosis. However, due to the extensive biological and genetic diversity of Vibrio species, current OmpK subunit vaccines can only target different strains of the same bacterial species or closely related species and have difficulty providing promising cross-immunoprotection against more diverse Vibrio infections. In recent years, the development of epitope-focused vaccines has been described as the latest stage in the development of vaccine formulations, providing new ideas for the development of broad-spectrum Vibrio vaccines.

Mechanistic insights into proton-coupled substrate translocation of nucleoside proton symporters.

The nucleoside: H symporter (NHS) family proteins are part of the major facilitator superfamily (MFS) and are responsible for transporting nucleosides from the extracellular environment into the cell. Structural and biochemical analysis of NupG, a prototypical NHS member, have pinpointed the critical residues involved in substrate binding. However, the proton-coupled mechanism diving substrate translocation in NHS proteins has remained elusive.

In vivo metabolic effects of naringin in reducing oxidative stress and protecting the vascular endothelium in dyslipidemic mice.

Naringin, a flavonoid, has high antioxidant activity and hypolipidemic pharmacological effects. In this study, an animal model of dyslipidemia was established by feeding Apoe mice a high-fat diet for 4 weeks. Subsequently, the mice were administered Naringin via gavage at doses of 50 mg/(kg·d), 100 mg/(kg·d), or 200 mg/(kg·d) for an additional 4 weeks.

Metal Ions Fortified Tannin-Furanic Rigid Foam: The Impact on the Uniformity and Mechanical Performance.

Tannin-furanic foams with excellent properties have attracted increasing interest due to their advantages such as easy preparation, light weight, and thermal insulation. However, unsatisfactory mechanical strength has limited the expansion of their applications. Herein, three different metal ions (Cu, Fe, and Zn) were chosen to enhance the properties of tannin-furanic foam prepared by mechanical stirring provoked a foaming approach.

Risk factors for perioperative cerebral infarction in moyamoya disease: a meta-analysis.

Background: The present study explored the risk factors for cerebral infarction perioperative moyamoya disease by meta-analysis.

Methods: The PubMed, Embase, Cochrane library, Web of science databases were searched for case-control/cohort studies on risk factors for the emergence of cerebral infarction perioperative moyamoya disease, the search was done from the database creation to June 1, 2024, and the data was analyzed by using stata15.0.

Berberine Inhibits Migration and Apoptosis of Rat Podocytes in Diabetic Nephropathy via the Novel lncRNA LOC102549726 Related Pathway.

Background: Diabetic nephropathy (DN) stands as one of the most severe complications of diabetes. Podocytes injury, particularly its attachment to the lateral glomerular basement membrane, serves as a crucial indicator of DN. Growing evidence suggests that berberine (BBR) can mitigate the onset and progression of DN.

Enzymatic degraded polysaccharides from Enteromorpha prolifera inhibit the growth of THP-1 cells and induce apoptosis via the mitochondrial pathway.

Polysaccharides from Enteromorpha prolifera (EP) is a kind of sulfated polysaccharides with complex structure. Several reports have showed that EP play roles in antioxidant and anti-inflammatory, while, whose function in anti-leukemia is still poorly understood. In this work, EPH were the hydrolysis products of EP by ulvan lyase EPL15085, which displayed lower molecular weight and enhanced sulfate groups than EP.

Associations between neighborhood risk and protective factors and parenting styles in Chinese American immigrant families.

Despite the rapid increase of the Chinese immigrant population in the United States, there is limited knowledge on how neighborhood context shapes parenting practices in Chinese immigrant families. Using data from a socioeconomically diverse sample of 239 Chinese American children (aged 7-10 years, 51.9% boys) in immigrant families, the present study examined the unique associations between neighborhood risk and protective factors and parenting styles in Chinese American families.

In-situ cross-linking strategy for achieving excellent impact resistance and thermal insulation of closed-cell poly(lactic acid) (PLA)/poly(4-hydroxybutyrate) (P4HB) foams.

Owing to inherent issues like interfacial stress concentration, open-cell, a low volume expansion ratio (VER) and cell density, the impact resistance and thermal insulation of supercritical foamed poly(lactic acid) (PLA) blend foams remain unsatisfactory. To overcome these challenges, an in-situ cross-linking strategy is employed to enhance the compatibility between PLA and poly(4-hydroxybutyrate) (P4HB), while improving the melt strength and crystallization behavior of the blends. The modified PLA/P4HB blend exhibits a blurred interfacial boundary with fewer stress concentrations.

Design and synthesis of novel sulfur-substituted triptolide with the ability to induce autophagy through inhibition of SRSF1 expression.

Six sulfur-substituted triptolide (TPL) analogs (STP1-6) were synthesized and evaluated for their biological functions. Among them, STP2 had significant antitumor activity both in vitro and in vivo. Notably, the intraperitoneal injections of 1 g/kg STP2 did not cause mice death and apparent pathological damage, while the mice in the TPL group (2 mg/kg) lost weight and all died within 4 days.

Construction of functional covalent organic framework films by modulator and solvent induced polymerization.

Covalent organic frameworks are attractive candidates for the next generation films in technical applications. However, due to their crystallization nature, insolubility in common solvents as well as infusible at high temperatures make it challenging to grow them spontaneously or process them into films. Herein, we report an efficient strategy to fabricate covalent organic framework films based on a modulator-solvent induced polymerization process.

Strawberry anthocyanin pelargonidin-3-glucoside attenuated OA-induced neurotoxicity by activating UPR.

In this study, network pharmacology analysis revealed that strawberry anthocyanins mainly interfered with lipid metabolism and nerve-related signaling pathways. Pelargonidin-3-glucoside (Pg3G), one of the main anthocyanins in strawberry, was screened as the most effective anthocyanin for attenuating excess lipid accumulation. Moreover, Pg3G decreased lipid levels, relieved oxidative stress, and restored abnormal behavioral activities in under oleic acid (OA) exposure.

Mechanistic investigation of impact of malic acid, ultrasound and dual treatment on starch digestibility of cooked whole rice grains.

Physical, chemical, and dual modifications can all significantly affect the digestibility of isolated rice granules, while their effects on the starch digestibility of whole cooked rice grains remain elusive. Therefore, the impact of malic acid, ultrasound, and ultrasound + malic acid dual treatment on the starch digestibility of cooked rice grains with different starch molecular structures was investigated in this study. Ultrasound mainly caused cavitation on the surface of rice grains, promoting the leaching of materials (> 11 %) and amylose during cooking.

Disruption of midgut homeostasis by microplastics in Spodoptera frugiperda: Insights into inflammatory and oxidative mechanisms.

Microplastics have evolved as widespread contaminants in terrestrial and aquatic environments, raising significant environmental concerns due to their persistence and bioaccumulation. In this study, we investigated the toxicity of polyethylene microplastics (PE-MPs) on the agricultural insect, Spodoptera frugiperda. Maize leaves containing three sizes (0.

Morphological and molecular characteristics of swine coccidia based on single oocyst isolation.

Swine coccidiosis is a host-specific protozoan disease caused by Cystoisospora suis and various Eimeria species, leading to diarrhea or subclinical signs in pigs. In this study, 3296 fecal samples from 55 farms across six provinces in China were collected and examined to determine the prevalence and molecular characteristics of swine coccidia. The single oocyst isolation technique (SOIT) and molecular characterization identified nine coccidian species, with an overall infection prevalence of 13.

Single-Cell RNA Sequencing Reveals the Cellular Origin and Evolution of Small-Cell Neuroendocrine Carcinoma of the Cervix.

Small-cell neuroendocrine cancer (SCNEC) of the uterine cervix is an exceedingly rare, highly aggressive tumor with an extremely poor prognosis. The cellular heterogeneity, origin, and tumorigenesis trajectories of SCNEC of the cervix remain largely unclear. We performed single-cell RNA sequencing and whole-exome sequencing on tumor tissues and adjacent normal cervical tissues from two patients diagnosed with SCNEC of the cervix.