Publications by authors named "Xinyang Hong"
Objectives: The Sarcopenia Index (SI) has the potential as a biomarker for sarcopenia, which is characterized by muscle loss. There is a clear association between sarcopenia and cognitive impairment. However, the relationship between SI and cognitive impairment is yet to be fully understood.
View Article and Find Full Text PDFDisturbance of REM sleep exacerbates microglial activation in APP/PS1 mice.
Neurobiol Learn Mem
April 2023
Article Synopsis
- Both NREM and REM sleep loss worsen Alzheimer's disease progression but have distinct effects on microglial activation.
- A study involving APP/PS1 mice found that REM deprivation (RD) and total sleep deprivation (TSD) both led to worse spatial memory and increased microglial activation compared to the control group.
- Microglial activation resulting from sleep disturbances may exacerbate neuroinflammation and synaptic damage while being less effective at clearing amyloid plaques in the context of Alzheimer's disease.