Three-dimensional flexible thermoelectric fabrics for smart wearables.

Wearable thermoelectric devices, capable of converting body heat into electrical energy, provide the potential driving power for the Internet of Things, artificial intelligence, and soft robotics. However, critical parameters have long been overlooked for these practical applications. Here, we report a three-dimensional flexible thermoelectric device with a structure featuring an inner rigid and outer flexible woven design.

Nanoarchitectonics of High-Performance and Flexible n-Type Organic-Inorganic Composite Thermoelectric Fibers for Wearable Electronics.

Since most conductive polymers are -type, developing high-performance -type organic-inorganic composite thermoelectric (TE) fibers is a great challenge. Herein, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)-coated AgTe nanowires (PC-AgTe NWs) were prepared by a liquid-phase reaction using PEDOT:PSS-coated Te nanowires (PC-Te NWs) as templates, and the PEDOT:PSS/PC-AgTe NWs composite fibers were then prepared by wet spinning. As the content of PC-AgTe NWs increases, the composite fiber changes from -type to -type.

Integrating single-cell sequencing and machine learning to uncover the role of mitophagy in subtyping and prognosis of esophageal cancer.

Globally, esophageal cancer stands as a prominent contributor to cancer-related fatalities, distinguished by its poor prognosis. Mitophagy has a significant impact on the process of cancer progression. This study investigated the prognostic significance of mitophagy-related genes (MRGs) in esophageal carcinoma (ESCA) to elucidate molecular subtypes.

Influencing factors and quantitative prediction of gas content of deep marine shale in Luzhou block.

The exploration and development of deep marine shale gas has made significant breakthroughs, but factors influencing gas contents of deep marine shale are elusive, and quantitative prediction methods of gas content needs to be refined urgently. In this study, the deep marine shale of Longmaxi Formation in Luzhou area was taken as an example, vitrinite reflectance analysis, kerogen microscopy experiment, TOC content analysis, mineral composition analysis, gas content measurement, isothermal adsorption experiment, physical property analysis and argon ion polishing scanning electron microscopy experiment were carried out to find out factors affecting the gas content of deep marine shale, and a gas content prediction model has been worked out. Conclusions below have been reached: the content of adsorbed gas is mainly affected by Ro, TOC content, porosity, water saturation, clay mineral content, formation temperature and pressure; the content of free gas is mainly controlled by porosity, water saturation, formation temperature and pressure; according to the prediction models, the adsorbed gas content, free gas content and total gas content of each well were quantitatively calculated, and the study area was divided into Class I (with a total gas content ≥ 11 m/t), Class II (with a total gas content between 9 m/t and 11 m/t), and Class III (with a total gas content < 9 m/t) gas-bearing areas.

Major adverse events associated with lipid reduction in inclisiran:a pharmacovigilance research of the FAERS database.

Objective: The effectiveness and safety of the short-interfering RNA drug inclisiran in lowering patients' lipoprotein cholesterol levels to lower their risk of cardiovascular disease are presently being investigated. Based on the real-world adverse event report record in the FDA Adverse Event Reporting System, this article explores the occurrence and risk of adverse events during inclisiran treatment.

Research Design And Methods: We retrieved and screened all available data from the Food and Drug Administration website for the period from 2009 to the third quarter of 2023.

Wearable Sensor Based on Covalent Organic Framework Humidity Films for Long-Term Monitoring of Tomato Physiology Under Abiotic Stress.

Global agricultural productivity is affected by plant stresses every year; as a consequence, monitoring and preventing plant stresses is a significant measure to protect the agro-ecological environment. Similar to the adoption of wearable devices to appraise human physiological information and disease diagnosis, however, in situ nondestructive monitoring of complex and weak physiological information in plants is an enormous challenge for the development of wearable sensors. Herein, to accurately analyze the changes of tomato internal information under multiple abiotic stresses in real-time, we introduce the covalent organic framework (COF) film synthesized by self-assembly layer by layer through the oil/water interface as a sensitive material to develop a multifilm-integrated wearable sensor capable of monitoring leaf surface humidity and leaf temperature.

Super Moisture-Sorbent Sponge for Sustainable Atmospheric Water Harvesting and Power Generation.

Sorption-based atmospheric water harvesting (SAWH) shows great promise to mitigate the worldwide water scarcity, especially in the arid regions. Salt-based composite materials are the extensively used sorbents for SAWH, however, they suffer from complex preparation to avoid salt leakage. Furthermore, the significant amount of heat produced during water harvesting process is often neglected and wasted.

Development of the TP53 mutation associated hypopharyngeal squamous cell carcinoma prognostic model through bulk multi-omics sequencing and single-cell sequencing.

Objective: The aim of this study was to construct a prognostic model based on the TP53 mutation to calculate prognostic risk scores of patients with HPSCC.

Methods: TP53 mutation and transcriptome data were downloaded from the TCGA databases. Gene expression data from GSE65858, GSE41613, GSE3292, GSE31056, GSE39366, and GSE227156 datasets were downloaded from the GEO database.

A Highly Robust, Multifunctional, and Breathable Bicomponent Fibers Thermoelectric Fabric for Dual-Mode Sensing.

Wearable thermoelectric (TE) materials are seen as excellent candidates for flexible electronics because of their unique self-powered properties, multistimulus sensing and human waste heat conversion. However, currently reported flexible TE materials still face challenges such as poor durability, uncomfortable wearing and sensing signals crosstalking each other. Herein, this study describes a hot-air cross-linking method for the preparation of multifunctional TE fabrics with enhanced durability.

Medical image analysis using improved SAM-Med2D: segmentation and classification perspectives.

Recently emerged SAM-Med2D represents a state-of-the-art advancement in medical image segmentation. Through fine-tuning the Large Visual Model, Segment Anything Model (SAM), on extensive medical datasets, it has achieved impressive results in cross-modal medical image segmentation. However, its reliance on interactive prompts may restrict its applicability under specific conditions.

Chemical structure and immunomodulatory activity of a polysaccharide from Saposhnikoviae Radix.

A new polysaccharide, named SP40015A01, was obtained from Saposhnikoviae Radix by water extraction, isolation and purification. SP40015A01 (9.7 × 10 Da) is composed of Rhamnose (Rha), Galacturonic acid (GalA), Galactose (Gal), and Arabinose (Ara) with the proportion of 1.

Advancements in materials, manufacturing, propulsion and localization: propelling soft robotics for medical applications.

Soft robotics is an emerging field showing immense potential for biomedical applications. This review summarizes recent advancements in soft robotics for and medical contexts. Their inherent flexibility, adaptability, and biocompatibility enable diverse capabilities from surgical assistance to minimally invasive diagnosis and therapy.

Sulfhydryl-Functionalized Amino Group Polymer Microcomposites toward Efficient Adsorption of Aqueous Cr(VI), As(III), Cd(II), and Pb(II).

The development of efficient adsorbents for heavy metal pollution, especially five toxic heavy metals, has attracted great research interest. Polymer-based adsorbents have aroused research value for their abundant functional groups and high porosity to the ability to capture metal ions. We designed a sulfhydryl-functionalized polymer microcomposite to take up Cr(VI), As(III), Cd(II), and Pb(II).

Collagen code in tumor microenvironment: Functions, molecular mechanisms, and therapeutic implications.

The tumor microenvironment (TME) is crucial in cancer progression, and the extracellular matrix (ECM) is an important TME component. Collagen is a major ECM component that contributes to tumor cell infiltration, expansion, and distant metastasis during cancer progression. Recent studies reported that collagen is deposited in the TME to form a collagen wall along which tumor cells can infiltrate and prevent drugs from working on the tumor cells.

Optimal postoperative surveillance strategies for cancer survivors with gastric neuroendocrine carcinoma based on individual risk: a multicenter real-world cohort study.

Background: The best follow-up strategy for cancer survivors after treatment should balance the effectiveness and cost of disease detection while detecting recurrence as early as possible. Due to the low incidence of gastric neuroendocrine carcinoma and mixed adenoneuroendocrine carcinoma [G-(MA)NEC], high-level evidence-based follow-up strategies is limited. Currently, there is a lack of consensus among clinical practice guidelines regarding the appropriate follow-up strategies for patients with resectable G-(MA)NEC.

Effects of Pre-Harvest Supplemental UV-A Light on Growth and Quality of Chinese Kale.

The effects of supplemental UV-A (385 nm) period and UV-A intensity for 5 days before harvest (DBH) on growth, antioxidants, antioxidant capacity, and glucosinolates contents in Chinese kale ( var. Bailey) were studied in plant factory. In the experiment of the UV-A period, three treatments were designed with 10 W·m UV-A supplement, T1(5 DBH), T2 (10 DBH), and no supplemental UV-A as control.

Tumor-associated macrophage-derived exosomes transmitting miR-193a-5p promote the progression of renal cell carcinoma via TIMP2-dependent vasculogenic mimicry.

Previous studies have investigated whether tumor-associated macrophages (TAMs) play tumorigenic and immunosuppressive roles to encourage cancer development, but the role of TAMs in regulating vasculogenic mimicry (VM) in clear-cell renal cell carcinoma (ccRCC) cells has not been completely clarified. We conducted immunostaining of the tumor-associated macrophage biomarkers CD68/CD163 and double staining for PAS/CD31 in ccRCC human specimens to find that higher TAM infiltration was positively correlated with VM formation. Then we demonstrated that TAM-derived exosomes downregulate TIMP2 expression in RCC cells to promote VM and invasion by shuttling miR-193a-5p.

Elevation of ADAM12 facilitates tumor progression by enhancing metastasis and immune infiltration in gastric cancer.

A disintegrin and metalloprotease 12 (ADAM12), an essential transmembrane protein with metalloprotease, cell binding and intracellular signal‑regulating capabilities, has been reported to play a crucial role in various types of cancers. However, the biological function of ADAM12 in gastric cancer (GC) remains unclear. Bioinformatic and experimental analyses were used to determine the expression level and prognostic value of ADAM12 in GC.

Preoperative prediction for lymph node metastasis in early gastric cancer by interpretable machine learning models: A multicenter study.

Background: The presence of lymph node metastasis plays a decisive role in the selection of treatment options in patients with early gastric cancer. However, there is currently no established protocol to predict the risk of lymph node metastasis before/after endoscopic resection. The aim of this study was to develop and validate several machine learning algorithms for clinical practice.

Stretchable Thermoelectric-Based Self-Powered Dual-Parameter Sensors with Decoupled Temperature and Strain Sensing.

Thermoelectric-based sensors with multifunctional sensing properties that can recognize different stimulations in a self-powered environment by converting low-grade heat into electrical energy have attracted increasing attention. However, the current thermoelectric-based multifunctional sensors are faced with issues such as limited preparation methods, complex structural designs, and hard decoupling, which greatly hinder their further development in the field of wearable electronics. Herein, we have fabricated novel free-standing self-powered temperature-strain sensors based on poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT:PSS)/carbon nanotube (CNT)/waterborne polyurethane (WPU) composite films through a simple drop-casting method.

Statins: a repurposed drug to fight cancer.

As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of their lipid-lowering effects. Among them, the anti-cancer properties of statins have attracted much attention and indicated the potential of statins as repurposed drugs for the treatment of cancer. A large number of clinical and epidemiological studies have described the anticancer properties of statins, but the evidence for anticancer effectiveness of statins is inconsistent.

MiR-450a-5p Inhibits Gastric Cancer Cell Proliferation, Migration, and Invasion and Promotes Apoptosis Targeting CREB1 and Inhibiting AKT/GSK-3β Signaling Pathway.

Gastric cancer seriously affects human health and research on gastric cancer is attracting more and more attentions. In recent years, molecular targets have become the research focus. Accumulating evidence indicates that miR-450a-5p plays a critical role in cancer progression.