Correction: Chen et al. The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment. 2023, 1568.

In the original publication [...

The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment.

Formaldehyde (FA) has been found to induce major Alzheimer's disease (AD)-like features including cognitive impairment, Aβ deposition, and Tau hyperphosphorylation, suggesting that it may play a significant role in the initiation and progression of AD. Therefore, elucidating the mechanism underlying FA-induced neurotoxicity is crucial for exploring more comprehensive approaches to delay or prevent the development of AD. Mangiferin (MGF) is a natural C-glucosyl-xanthone with promising neuroprotective effects, and is considered to have potential in the treatment of AD.

The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer's disease: A systematic review and meta-analysis.

Background: Formaldehyde (FA), a toxic aldehyde, has been shown to be associated with a variety of cognitive disorders, including Alzheimer's disease (AD). There is increasing evidence that FA levels are significantly increased in AD patients and may be involved in the pathological process of AD. The aim of this study was to assess the potential diagnostic value of urine FA levels in AD using meta-analysis techniques.

Two new 8-isopentenyl isoflavane derivatives from diels.

Astragali Radix (Huangqi) is one of the well-known traditional Chinese medicines and has been used in China for more than two thousand years. As a close species, Diels was found to possess cytotoxicity during our preliminary study of plants from Yunnan Province, China. To better understand the chemical foundation of the cytotoxicity, the major constituents of .

Astrernestin, a novel aurone-phenylpropanoid adduct from the roots of .

has been used as a substitute for Radix Astragali (Huang-Qi) in southwest China. To better understand the chemical rationale for the medicinal usage, the phytochemistry of . was recently studied.

Hispidanins A-D: four new asymmetric dimeric diterpenoids from the rhizomes of Isodon hispida.

Hispidanins A-D (1-4), four unprecedented asymmetric dimeric diterpenoids, were obtained from the rhizomes of Isodon hispida. Their structures were elucidated by extensive spectroscopic analysis (1D and 2D NMR, MS, UV, IR), as well as single-crystal X-ray diffraction analysis. Hispidanin B showed significant cytotoxicities against tumor cell lines SGC7901, SMMC7721, and K562, with IC50 values of 10.

[Pharmacognostical study on seven species from Astragalus genus in Yunnan].

Objective: For the identification and utilization of the Astragalus plants from Yunnan, pharmacognostical studies were systematically performed for seven Astragalus plants which were selected from four subgenera of Astragalus genus.

Methods: Standard pharmacognosy methods and HPLC method were adopted, and microscopic characteristics and major chemical constituents of the test plant samples were compared.

Results: There were differences in root transverse section, powder and chemical constituents of the seven Astragalus plants.