Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis.

Background: B cell immune dysregulation plays a critical role in myasthenia gravis (MG). However, targeted B-cell therapy such as rituximab may result in long-term peripheral B cell clearance and allow for the survival of plasma cells, contributing to frequent infections and relapses. Therefore, we aimed to identify potential novel therapeutic targets that preserve part of B cell function while inhibiting antibody-secreting cells (ASCs).

Diversifying configurational paths for athlete data protection.

In the digital era, data has become a core resource driving the development of the global sports industry. With the increasing awareness of athlete data protection, ensuring the security of this sensitive information worldwide has become a significant issue. This study employs configurational theory and Fuzzy-set Qualitative Comparative Analysis to investigate the various factors affecting athlete data protection.

Organophosphorus Hydrolase-like Nanozyme with an Activity-Quenched Aggregation-Induced Emission Effect: A Self-Reporting and Specific Assay of Nerve Agents.

Given the promising prospect of aggregation-induced emission luminogens (AIEgens) in fluorescence assays, it is interesting and significant to endow AIEgens with molecular recognition capability (such as enzyme-like activity). Here, an AIE nanomaterial with intrinsic enzyme-like activity (named as "AIEzyme") is designed and synthesized via a facile coordination polymerization of Zr and AIE ligands. AIEzyme possesses enhanced and stable fluorescence in different solvents because of the AIE effect of ligands in the rigid structure of a coordination polymer.

Curcumin and its nano-formulations combined with exercise: From molecular mechanisms to clinic.

Curcumin is a strong substance derived from turmeric, a popular spice, renowned for its antioxidant and anti-inflammatory abilities. The study delved deeply into a thorough examination of various sources to evaluate the impact of both regular curcumin and nano-formulated curcumin on elements that impact physical performance, including muscular strain, discomfort, swelling, and oxidative tension. While engaging in exercise, the body experiences a rise in reactive oxygen species and inflammation.

Anti-neuroinflammatory effect of hydroxytyrosol: a potential strategy for anti-depressant development.

Depression is a complex psychiatric disorder with substantial societal impact. While current antidepressants offer moderate efficacy, their adverse effects and limited understanding of depression's pathophysiology hinder the development of more effective treatments. Amidst this complexity, the role of neuroinflammation, a recognized but poorly understood associate of depression, has gained increasing attention.

Factors affecting the protection of data rights in sports events: a configurational analysis.

The development of algorithms and the spread of digital infrastructure have contributed significantly to the productivity of the digital economy. Data has come to be known as the "oil of the digital economy". At the same time, data has begun to participate more deeply in the production activities of the global sports industry chain, and the international discussion on how to protect the rights of sports event data has been increasing.

A tripartite evolutionary game analysis of sports data rights protection from the perspective of stakeholder.

The amount of data in the globe is increasing at an exponential rate, and the role of digital technology and data elements in the modern growth of China's sports business is becoming more significant. Disputes over sports data rights have grown in the international arena, with a special focus on how to preserve the sports data rights of key stakeholders. This study begins from the standpoint of stakeholders, constructs a tripartite evolutionary game model of the government, sports enterprises, and the public around the issue of sports data rights protection, investigates the behavioral evolutionary characteristics of each stakeholder and its stabilization strategies, simulates and analyzes the evolutionary stabilization strategies of the stakeholders in various situations using MATLAB, and proposes a compatible institution.

Flexural Behavior of Damaged Hollow RC Box Girders Repaired with Prestressed CFRP.

In recent years, numerous studies have explored the benefits of utilizing prestressed carbon fiber-reinforced polymer (CFRP) for strengthening concrete structures. However, research on the reinforcement of prestressed CFRP on full-scale hollow RC box girders, particularly damaged bridges, remains limited. In this study, both experiments and finite element analysis (FEA) were performed to investigate the flexural behavior of full-scale hollow RC box girders with varying degrees of damage, which were strengthened using CFRP with different levels of prestress.

Ascorbic Acid-Caused Quenching Effect of Protein Clusteroluminescence Probe: The Fast Fluorescent Detection of Ascorbic Acid in Vegetables.

It is interesting and meaningful to explore fluorescent probes for novel rapid detection methods. In this study, we discovered a natural fluorescence probe, bovine serum albumin (BSA), for the assay of ascorbic acid (AA). Due to clusterization-triggered emission (CTE), BSA has the character of clusteroluminescence.

Patient-derived models: Promising tools for accelerating the clinical translation of breast cancer research findings.

Breast cancer has become the highest incidence of cancer in women. It was extensively and deeply studied by biologists and medical workers worldwide. However, the meaningful results in lab researches cannot be realized in clinical, and a part of new drugs in clinical experiments do not obtain as good results as the preclinical researches.

PDPN positive CAFs contribute to HER2 positive breast cancer resistance to trastuzumab by inhibiting antibody-dependent NK cell-mediated cytotoxicity.

Trastuzumab is a humanized monoclonal antibody, and has been clinical employed to treat human epidermal growth factor receptor 2 (HER2) positive breast cancer. However, drug resistance to trastuzumab remains a challenge due to the generally uncharacterized interactive immune responses within the tumor tissue. In this study, by means of single-cell sequencing, we identified a novel podoplanin-positive (PDPN) cancer-associated fibroblasts (CAFs) subset, which was enriched in trastuzumab resistant tumor tissues.

Interferon-τ -induced ISG15-AS regulates endometrial receptivity during early goat pregnancy.

Endometrial receptivity is a critical process for the successful establishment of pregnancy in ruminants. However, the biological role of long non-coding RNAs (lncRNAs) in the development of endometrial receptivity is poorly understood. In this study, we performed RNA-seq analysis of immortalised goat endometrial epithelial cells (gEECs) treated with interferon-τ (IFNT).

Comparative analysis of the sorption behaviors and mechanisms of amide herbicides on biodegradable and nondegradable microplastics derived from agricultural plastic products.

Coexisting of microplastics (MPs) and residual herbicides has received substantial attention due to concerns about the pollutant vector effect. Here, the widely used amide herbicides were examined for their sorption behaviors on the priority biodegradable and nondegradable MPs identified in intensive agriculture. The fitting results indicated that the interactions between napropamide (Nap)/acetochlor (Ace) and the MPs, i.

The persistent, bioaccumulative, toxic, and resistance (PBTR) risk assessment framework of antibiotics in the drinking water sources.

Antibiotics are emerging pollutants largely considered to have a lower risk based on persistent, bioaccumulative, toxic (PBT) risk assessments. However, an increasing number of studies have illustrated that antibiotics are responsible for the global increase in antimicrobial resistance (AMR), which suggests that the risk of antibiotics has been largely underestimated by using PBT risk assessment. Here, we designed an integrated innovation risk assessment framework of persistent, bioaccumulative, toxic, and resistance (PBTR) that accounts for antibiotic resistance to better represent the antibiotic environmental risk.

Flexural Behavior of Full-Scale Damaged Hollow RC Beams Strengthened with Prestressed SCFRP Plate under Four-Point Bending.

The advantages of using prestressed carbon fiber reinforced polymer (CFRP) for strengthening and retrofitting structures have been reported in recent years. In this regard, most of the studies on prestressed CFRP technique have been carried out in the laboratory test with small-scale and no damage (reinforced concrete) RC beam. However, the real structures that need to be retrofitted in service are often degraded or damaged due to early cracking.

Designer Exosomes for Targeted Delivery of a Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma.

Sorafenib is one of the few effective first-line drugs approved for the treatment of advanced hepatocellular carcinoma (HCC). However, the development of drug resistance is common among individuals with HCC. Recent evidence indicated that the anticancer activity of sorafenib mainly relies on the induction of ferroptosis.

Fatigue Life Prediction of CFRP-Strengthened RC Beams with Flexural Crack under Hygrothermal Environments.

The durability of reinforced concrete (RC) beams strengthened with carbon fiber-reinforced polymer (CFRP) is a worldwide concern in structural engineering. As an important part of the strengthened beam, the performance of the CFRP-concrete interface under hygrothermal environments is a delicate problem. In this paper, the fatigue behavior of CFRP-strengthened RC beams is analyzed by a theoretical model.

A Study on the Bond-Slip Relationship of the CFRP-Steel Interface of CFRP Strengthened Steel.

The bonding interface between the CFRP and the steel plate is the weak link of CFRP-strengthened steel structures. This paper studies the bond-slip relationship of the CFRP-steel interface by experiments and numerical tests. First, a series of double-strap experiments on a CFRP-strengthened steel plate are carried out.

Evaluation of the water pollution risk of dam and dike-break floods in the inundated area.

The inundated area of dam and dike-break floods includes various types of land and factories that release considerable amounts of pollutants into floods, causing serious water pollution and further endangering human health. Many pollution sources and factors affect the water pollution risk in inundated areas. Accurate assessment of the water pollution risk for dam and dike-break floods enables people to take measures in advance to reduce public health problems.

Design, synthesis and bioactive evaluation of geniposide derivatives for antihyperuricemic and nephroprotective effects.

Hyperuricemia is a principal factor mediating gout and kidney damage, and xanthine oxidase (XOD) is a key enzyme in the pathogenesis of hyperuricemia. In this context, a series of geniposide derivatives were designed and synthesized, and antihyperuricemic and nephroprotective effects of all derivatives was evaluated in vitro and in vivo. Compound 2e emerged as the most potent XOD inhibitor, with an IC value of 6.

Long-term live-cell lipid droplet-targeted biosensor development for nanoscopic tracking of lipid droplet-mitochondria contact sites.

Lipid droplets (LDs) establish a considerable number of contact sites with mitochondria to enable energy transfer and communication. In this study, we developed a fluorescent biosensor to image LD-mitochondria interactions at the nanoscale and further explored the function of LD-mediated matrix transmission in processes involving multi-organelle interactions. A fluorescent probe called (CHNO, 7-(diethylamino) coumarin-3-vinyl-4-pyridine acetonitrile) was designed and synthesized.

Ufmylation regulates granulosa cell apoptosis via ER stress but not oxidative stress during goat follicular atresia.

Follicular atresia is primarily caused by granulosa cell (GC) apoptosis, although the mechanisms are largely unknown. Ufmylation is a recently identified ubiquitin-like post-translational modifier that plays an important role in cell proliferation and apoptosis. The purpose of this study was to investigate the effects of Ufmylation on GC apoptosis during goat follicular atresia.

Impact of extreme floods on plants considering various influencing factors downstream of Luhun Reservoir, China.

Extreme floods caused by dike or dam breaks have led to substantial damage to various types of vegetation, including forests, orchards, grass, and crops. Many factors affect the impacts of extreme floods on plants, e.g.