Exploring the Research Focus of RNA-Binding Proteins in Trauma and Burns.

Trauma and burns are leading causes of death and significant global health concerns. RNA-binding proteins (RBPs) play a crucial role in post-transcriptional gene regulation, influencing various biological processes of cellular RNAs. This study aims to review the emerging trends and key areas of research on RBPs in the context of trauma and burns.

Revealing the Therapeutic Potential of Stem Cells in Burn Healing: A Deeper Understanding of the Therapeutic Mechanisms of Epidermal Stem Cells and Mesenchymal Stem Cells.

Burns are a global public health issue and a major cause of disability and death around the world. Stem cells, which are the undifferentiated cells with the potential for indefinite proliferation and multilineage differentiation, have the ability to replace injured skin and facilitate the wound repair process through paracrine mechanisms. In light of this, the present study aims to conduct a bibliometric analysis in order to identify research hotspots of stem cell-related burns and assess global research tendencies.

Degarelix limits the survival of mycobacteria and granuloma formation.

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, is a serious health hazard, characterized by tuberculous granuloma formation, which may facilitate bacterial survival. At the same time, the identification of multidrug-resistant and extremely drug-resistant Mtb strains, and the progressive accumulation of mutations in biological targets of frontline antimicrobials, has made TB treatments more difficult. Therefore, new and rapid drug development for TB is warranted.

Scholarly knowledge fundamentals and dynamic research hotspots in the field of burns and immunology: A bibliometric analysis.

Background: An estimated 180,000 burn deaths occur each year, and the immune system plays a vital role in wound healing and burn complications, including inflammatory reactions and oxidative stress. This paper aims to explore the basic knowledge and dynamic hotspots in burns and immunology research with bibliometric methods.

Methods: Through systematic retrieval, we ensured all the documents complied with our retrieval strategy and were included in the Science Citation Index-Expanded of the Web of Science Core Collection.

Delayed admission to hospital with proper prehospital treatments prevents severely burned patients from sepsis in China: A retrospective study.

Background: Sepsis is one of the major causes of morbidity and mortality in burn patients. However, the optimal timing of admission which can minimize the probability of sepsis is still unclear. This study aims to determine the optimal time period of admission for severely burned patients and find out the possible reasons for it.

Amniotic miracle: Investigating the unique development and applications of amniotic membrane in wound healing.

Background: The perfect repair of damaged skin has always been a constant goal for scientists; however, the repair and reconstruction of skin is still a major problem and challenge in injury and burns medicine. Human amniotic membrane (hAM), with its good mechanical properties and anti-inflammatory, antioxidant and antimicrobial benefits, containing growth factors that promote wound healing, has evolved over the last few decades from simple skin sheets to high-tech dressings, such as being made into nanocomposites, hydrogels, powders, and electrostatically spun scaffolds. This paper aims to explore the historical development, applications, trends, and research hotspots of hAM in wound healing.

A 10-year mono-center study on patients with burns ≥70% TBSA: prediction model construction and multi-center validation: retrospective cohort.

Background: Burn injuries with ≥70% total body surface area (TBSA) are especially acute and life-threatening, leading to severe complications and terrible prognosis, while a powerful model for prediction of overall survival (OS) is lacked. The objective of this study is to identify prognostic factors for the OS of patients with burn injury ≥70% TBSA, construct and validate a feasible predictive model.

Materials And Methods: Patients diagnosed with burns ≥70% TBSA admitted and treated between 2010 and 2020 in our hospital were included.

Tracing the evolving dynamics and research hotspots of microbiota and immune microenvironment from the past to the new era.

Gut microbiota can regulate many physiological processes within gastrointestinal tract and other distal sites. Dysbiosis may not only influence chronic diseases like the inflammatory bowel disease (IBD), metabolic disease, tumor and its therapeutic efficacy, but also deteriorate acute injuries. This article aims to review the documents in this field and summarize the research hotspots as well as developing processes.

Effects of climate change and grazing intensity on grassland productivity-A case study of Inner Mongolia, China.

In the last 30 years, grassland productivity has declined seriously due to climate variations and unreasonable human activities. Therefore, to analyze the impact of different factors on grassland productivity, we selected three grassland stations of the Typical Steppe from west to east and collected 38 years of data. The Pearson Correlation and Fixed Effect Model were used to analyze the impact of precipitation, temperature, and grazing intensity on grassland productivity.

L-Tyrosine Limits Mycobacterial Survival in Tuberculous Granuloma.

Caused by the intracellular pathogen (Mtb), tuberculosis (TB) remains a massive global public health issue. A well-known and key TB trait is caseous necrotic granuloma, which allows mycobacteria to reactivate and disseminate, thus confounding TB eradication programs. Amino acid (AA) metabolism is key to regulating immune responses in Mtb infections; however, it is currently unclear if AAs can be used to treat tuberculous granulomas.

Sequencing technology as a major impetus in the advancement of studies into rheumatism: A bibliometric study.

Background: Rheumatism covers a wide range of diseases with complex clinical manifestations and places a tremendous burden on humans. For many years, our understanding of rheumatism was seriously hindered by technology constraints. However, the increasing application and rapid advancement of sequencing technology in the past decades have enabled us to study rheumatism with greater accuracy and in more depth.

An empirical study of the key factors affecting herders' purchasing decision on weather index insurance-A case study from inner Mongolia autonomous region, China.

The weather index insurance for mutton sheep (WIMS) is the first weather index insurance product that addresses the increased feeding cost-related risk of grassland animal husbandry herders in China. In 2019, the WIMS was implemented as a pilot project in 11 county regions of Xilin Gol League, Inner Mongolia, China. Since the implementation of this product, the purchasing rate has varied from region to region, as the highest purchasing rate was 84.

Fire Extinguishing Performance of Chemically Bonded Struvite Ceramic Powder with High Heat-Absorbing and Flame Retardant Properties.

Struvite is a chemically bonded ceramic product in the pipeline of a sewage treatment plant. In order to explore the fire extinguishing potential of struvite, a new type of struvite ultrafine dry powder with excellent performance was prepared by a simple process, and its fire extinguishing performance and mechanism were analyzed in depth. Under the same process conditions, the refinement degree (D50 = 5.

Correction: Ye et al. Investigation of the JASMONATE ZIM-DOMAIN Gene Family Reveals the Canonical JA-Signaling Pathway in Pineapple. 2022, , 445.

The authors would like to make the following correction to the published paper [...

Investigation of the JASMONATE ZIM-DOMAIN Gene Family Reveals the Canonical JA-Signaling Pathway in Pineapple.

JASMONATE ZIM-DOMAIN (JAZ) proteins are negative regulators of the jasmonate (JA)-signaling pathway and play pivotal roles in plant resistance to biotic and abiotic stresses. Genome-wide identification of JAZ genes has been performed in many plant species. However, systematic information about pineapple ( L.

Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity.

Pathogenic mycobacteria induce the formation of hypoxic granulomas during latent tuberculosis (TB) infection, in which the immune system contains, but fails to eliminate the mycobacteria. Fatty acid metabolism-related genes are relatively overrepresented in the mycobacterial genome and mycobacteria favor host-derived fatty acids as nutrient sources. However, whether and how mycobacteria modulate host fatty acid metabolism to drive granuloma progression remains unknown.

Molecular cloning and functional characterization of from soybean ().

Aminoalcoholphosphotransferase (AAPT) utilizes diacylglycerols and cytidine diphosphate-choline/ethanolamine as substrates for the synthesis of phosphatidylcholine (PC)/phosphatidylethanolamine (PE). Plant AAPTs involved in phospholipid metabolism mediate diverse physiological processes; however, little is known about their functions in triacylglycerol (TAG) metabolism and seed germination. In the present study, we isolated and characterized two AAPTs, GmAAPT1 and GmAAPT2, from soybean ().

Hypercrosslinked phenothiazine-based polymers as high redox potential organic cathode materials for lithium-ion batteries.

Organic cathode materials have been demonstrated to be highly promising sustainable cathode materials for rechargeable lithium-ion batteries. However, the low redox potentials, low electrical conductivity, and the undesirable dissolution in organic electrolytes greatly limit their applications. Herein, two insoluble hypercrosslinked porous conductive polymers with phenothiazine motifs, HPEPT and HPPT, were successfully accomplished with high and stable discharge potentials at 3.

Notch1a can widely mediate innate immune responses in zebrafish larvae infected with Vibrio parahaemolyticus.

The Notch signaling pathway is known to regulate innate immunity by influencing macrophage function and interacting with the Toll-like receptor (TLR) signaling pathway. However, the comprehensive role of the Notch signaling pathway in the innate immune response remains unknown. To assess the function of Notch1a in immunity, we examined the innate immune responses to Vibrio parahaemolyticus strain Vp13 of wild-type (WT) and notch1a zebrafish larvae generated using the clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) system.

Transcriptomic analysis of microRNAs-mRNAs regulating innate immune response of zebrafish larvae against Vibrio parahaemolyticus infection.

In recent years, microRNAs (miRNAs) have been shown to play important roles in immunity. Analyses of the functions of miRNAs and their targets are useful in understanding the regulation of the immune response. To understand the relationships between miRNAs and their targets during infection, we used zebrafish as an infection model in which to characterize the miRNA and mRNA transcriptomes of zebrafish larvae infected with Vibrio parahaemolyticus.