Efficacy and safety of Weichang' an pill combined with Western Medicine on gastrointestinal diseases: a systematic review and Meta-analysis.

Objective: To systematically evaluate the efficacy and safety of Weichang'an pill (, WCA) combined with Western Medicine (WM) for the treatment of gastrointestinal diseases.

Methods: Eight databases, including China National Knowledge Infrastructure Database, Wanfang Data, China Science and Technology Journal Database, SinoMed, PubMed, Web of Science, Cochrane Library, and Embase, were searched for randomized controlled trials (RCTs) of WCA from inception to 30 September 2021. We independently screened the literature, extracted data, and then evaluated the bias risk, effectiveness, safety, and other indicators of the included articles.

Under-loaded operation of an anaerobic-anoxic-aerobic system in dry and wet weather dynamics to prevent overflow pollution: Impacts on process performance and microbial community.

Effects of low hydraulic loading rate (HLR) in dry weather and high HLR in wet weather on pollutant removal, microbial community, and sludge properties of a full-scale wastewater treatment plant (WWTP) were extensively studied to explore the risk of under-loaded operation for overflow pollution control. Long-term low HLR operation had an insignificant effect on the pollutant removal performance of the full-scale WWTP, and the system could withstand high-load shocks in wet weather. Low HLR resulted in higher oxygen and nitrate uptake rate due to the storage mechanism under the alternating feast/famine condition, and lower nitrifying rate.

Gut microbiota: A new target of traditional Chinese medicine for insomnia.

All species have a physiological need for sleep, and sleep is crucial for the preservation and restoration of many physiological processes in the body. Recent research on the effects of gut microbiota on brain function has produced essential data on the relationship between them. It has been discovered that dysregulation of the gut-brain axis is related to insomnia.

Integrated pyroptosis measurement and metabolomics to elucidate the effect and mechanism of tangzhiqing on atherosclerosis.

Tangzhiqing formula (TZQ) is a traditional Chinese medicine prescribed to treat glucose and lipid metabolism disorders. A significant effect of TZQ on diabetes and hyperlipidemia has been demonstrated, but its effect on atherosclerosis (AS) remains unknown. This study combines pyroptosis with metabolomics to elucidate the effect and mechanism of TZQ on AS.

A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: Macrophage polarization.

Intestinal macrophages are the main participants of intestinal immune homeostasis and intestinal inflammation. Under different environmental stimuli, intestinal macrophages can be polarized into classical activated pro-inflammatory phenotype (M1) and alternative activated anti-inflammatory phenotype (M2). Its different polarization state is the "guide" to promoting the development and regression of inflammation.

Effects of Lipid Overload on Heart in Metabolic Diseases.

Metabolic diseases are often associated with lipid and glucose metabolism abnormalities, which increase the risk of cardiovascular disease. Diabetic cardiomyopathy (DCM) is an important development of metabolic diseases and a major cause of death. Lipids are the main fuel for energy metabolism in the heart.

Liming and tillering application of manganese alleviates iron manganese plaque reduction and cadmium accumulation in rice (Oryza sativa L.).

The application time and soil pH are key to manganese (Mn) bioavailability, which may influence Mn effects on cadmium (Cd) accumulation in rice. Accordingly, this study investigated the effects of Mn application at different stages, alone or with basal liming, on Cd accumulation in rice through pot and field experiments. The results showed that basal Mn application maximally elevated soil dissolved Mn, and increasing Mn accumulation in rice by 140%-367% compared to the control.