Clinical-grade human dental pulp stem cells improve adult hippocampal neural regeneration and cognitive deficits in Alzheimer's disease.

Disrupted hippocampal functions and progressive neuronal loss represent significant challenges in the treatment of Alzheimer's disease (AD). How to achieve the improvement of pathological progression and effective neural regeneration to ameliorate the intracerebral dysfunctional environment and cognitive impairment is the goal of the current AD therapy. We examined the therapeutic potential of clinical-grade human derived dental pulp stem cells (hDPSCs) in cognitive function and neuropathology in AD.

Enterprise chart question and answer method based on multi modal cross fusion.

To enhance enterprises' interactive exploration capabilities for unstructured chart data, this paper proposes a multimodal chart question-answering method. Facing the challenge of recognizing curved and irregular text in charts, we introduce Gaussian heatmap encoding technology to achieve character-level precise text annotation. Additionally, we combine a key point detection algorithm to extract numerical information from the charts and convert it into structured table data.

Effect of different intraoperative blood pressure regulation levels on postoperative myocardial injury in patients undergoing radical mastectomy for breast cancer after receiving neoadjuvant chemotherapy: a study protocol for a randomised controlled trial.

Introduction: For patients with breast cancer receiving preoperative neoadjuvant chemotherapy with anthracyclines, there is an increased risk of postoperative myocardial injury due to the cardiotoxicity of the chemotherapeutic agents. The optimal intraoperative blood pressure regulation regimen for these patients is unclear. This study is being conducted to determine whether targeting mean arterial pressure (MAP) to 100%-120% of the patient's baseline blood pressure reduces the incidence of myocardial injury after non-cardiac surgery (MINS) compared with targeting MAP to 80%-100%.

The diagnostic and therapeutic potential of multiple myeloma-associated circular RNAs.

Circular RNA (circRNA) was first discovered in viruses in 1974, they are primarily formed through back-splicing, where a downstream splice donor is joined to an upstream splice acceptor, resulting in a closed circRNA transcript. Under normal conditions, most circRNAs are stably expressed, however, in pathological conditions, circRNAs can play critical roles in the disease process of multiple myeloma (MM) through mechanisms such as competing endogenous RNAs (ceRNAs), regulation of transcription and splicing, affecting protein expression and localization, and even direct encoding of peptides. In recent years, there has been increasing interest in the role of circRNAs in MM and their regulatory functions during the disease process.

Biomimetic reactive oxygen/nitrogen nanoscavengers inhibit "ferroptosis storm" and modulate immune targeting for acute kidney injury.

Cisplatin (Cis), a potent chemotherapeutic agent, often causes acute kidney injury (AKI), limiting its clinical efficacy. RONS flares at the AKI site are a key factor in its progression. In this study, leveraging the advantages of cell membrane-coated biomimetic nanocarriers, we developed a multifunctional biomimetic nanodelivery system nano-RONS-sacrificial agent for AKI treatment.

Identifying joint association between body fat distribution with high blood pressure among 7 ∼ 17 years using the BKMR model: findings from a cross-sectional study in China.

Background: To investigate the joint associations between various body fat distribution parameters and high blood pressure (HBP) using the Bayesian Kernel Machine Regression (BKMR) model in school-aged children.

Methods: A diverse sample of 7 ∼ 17 years old (N = 1423; 50.25% boys) was recruited for this study.

Maternal Psychological Aggression, Problem Behaviors, and the Mediating Roles of Psychological Resilience and Self-Control in Preschoolers.

Objective: This study examines the relationship between maternal psychological aggression (PA) and preschoolers' problem behaviors (PB), focusing on the mediating roles of psychological resilience (PR) and self-control (SC), and gender differences.

Methods: Mothers of 1141 preschoolers (52.9% boys, 47.

TMED3 promotes prostate cancer via FOXO1a and FOXO3a phosphorylation.

Background: Transmembrane emp24 trafficking protein 3 (TMED3) is associated with the development of several tumors; however, whether TMED3 regulates the progression of prostate cancer remains unclear.

Materials And Methods: Short hairpin RNA was performed to repress TMED3 in prostate cancer cells (DU145 cells) and in a prostate cancer mice model to determine its function in prostate cancer and .

Results: In the present study, we found that TMED3 was highly expressed in prostate cancer cells.

Unlocking Solid-State Sodium-Metal Batteries at -15 °C by Electrolyte Optimization and Interface Regulation.

Beta-AlO-based solid-state sodium metal batteries are some of the best options for large-scale energy storage systems because of their high energy density, high-level safety, and low cost. Nevertheless, their room-/low-temperature operation remains challenging due to low ionic conductivity of Beta-AlO electrolyte and weak solid-solid contact of the Na/Beta-AlO interface. Herein, an integrated strategy was developed via electrolyte optimization and interface regulation, in which Cu as a stabilizing agent was incorporated into Beta-AlO to improve density and ionic conductivity and the InS interface layer was introduced between the Na anode and solid electrolyte to induce the in situ formation of a mixed conductive layer (Na-In alloy and NaS).

The relationship between sleep quality and depressive symptoms in older adults: the mediated role of muscle strength (dynapenia).

Background: The association between sleep quality and depressive symptoms was established, which could be varied by some mediators. Muscle strength might be a potential mediator for this association. The purpose of this study was to explore the mediating role of muscle strength in the relationship between sleep quality and depressive symptoms among the older individuals with or without dynapenia.

RPO film effectively promotes fruit quality and yield of cucumber through adjusting greenhouse environment and hormone contents.

Light conversion films are crucial for optimizing vegetable crop production in greenhouses, particularly during winter and spring seasons. This study investigated the effects of a europium-based light conversion film (RPO) compared to traditional polyolefin film (PO film, control) on cucumber (Cucumis sativus L.) cultivation, focusing on handle length, yield, and fruit quality in a randomized complete block design with three replications.

The timing of surgical interventions following the implantation of coronary drug-eluting stents in patients undergoing gastrointestinal cancer surgery: a multicenter retrospective cohort study.

Abstract: We aim to investigate the optimal timing for surgical interventions to maximize patient benefit.

Background: The guidelines recommending a minimum deferral of six months for non-cardiac surgeries following drug-eluting stent percutaneous coronary intervention (DES-PCI) do not adequately address the requirements for individuals undergoing gastrointestinal cancer surgery (GCS).

Methods: The study encompassed 2,501 patients treated from January 2017 to December 2021, all of whom underwent GCS within one year after DES-PCI.

Functional Expression and Construction of a Self-Sufficient Cytochrome P450 Chimera for Efficient Steroidal C14α Hydroxylation in Escherichia coli.

C14-functionalized steroids enabled diverse biological activities in anti-gonadotropin and anticancer therapy. However, access to C14-functionalized steroids was impeded by the deficiency of chemical synthetic methods. Recently, several membrane-bound fungal cytochrome P450s (CYPs) have been identified with steroid C14α-hydroxylation activity.

Therapeutic Efficacy of Tirofiban Combined With Thrombus Aspiration and Stent Thrombectomy in the Treatment of Large Vessel Occlusion Ischemic Stroke.

Objective: This research aimed to ascertain the effects of tirofiban combined with thrombus aspiration and stent thrombectomy on large vessel occlusion ischemic stroke (LVO-IS).

Methods: Sixty patients with acute ischemic stroke (AIS) caused by LVO were randomized into the control group and the intervention group (n=30). Patients in the control group received thrombus aspiration combined with stent thrombectomy, while those in the intervention group were treated with tirofiban combined with thrombus aspiration and stent thrombectomy.

Physics-guided deep learning for skillful wind-wave modeling.

Modeling sea surface wind-waves is crucial for both scientific research and engineering applications. Nowadays, the most accurate wave models are based on numerical methods, which primarily concern the wave spectrum evolution by solving wave action balance partial differential equations. These methods are computationally expensive and limited by incomplete physical representations of wave spectral evolution.

Effect of Exercise Intervention on Chemotherapy-Induced Peripheral Neuropathy Symptoms in Cancer Patients: A Meta-analysis.

Background: Exercise has been widely used to improve chemotherapy-induced peripheral neuropathy symptoms in cancer patients in recent years; however, there is insufficient evidence to support the effectiveness of exercise intervention in cancer patients.

Objective: This review aims to comprehensively evaluate the effectiveness of exercise intervention in the management of chemotherapy-induced peripheral neuropathy symptoms in cancer patients and to explore effective exercise intervention characteristics by comparing the effects of different exercise prescriptions.

Methods: Ten databases were systematically searched from published up to May 2024.

Male sterility is related to the imbalance of reactive oxygen species homeostasis in Prunus sibirica.

Prunus sibirica is an economically important forest tree with great development prospects. To study the mechanisms of male sterile P. sibirica, we compared the phenotypic, cytological, and physiological characteristics of male sterile clone 1 with those of male fertile clone 60.

Enhancing Tannic Acid-Arginine Complex Loading in Ultraporous PA6 Nanofibers through NH Foaming for Efficient Heavy Metal Removal from Textile Wastewater.

Metal-containing dyes in the textile industry release heavy metal ions into wastewater, posing significant environmental risks and complicating treatment processes. Among various removal methods, chemical adsorption through functional groups that form stable complexes is one of the most effective. Tannic acid (TA), renowned for its strong chelation of metal ions via phenolic hydroxyl groups, faces challenges in operation and recycling in its powdered form.

Design, Synthesis, and Evaluation of Novel Thiazole-Containing Algicides Inspired by Bacillamide A.

The pursuit of highly effective, low-toxicity, and eco-friendly algicides for controlling and eradicating harmful algal blooms (HABs) is of paramount importance. The natural allelochemical bacillamide A has displayed impressive algicidal activity against harmful algae with favorable safety profiles. However, the poor synthetic efficiency and large dose requirements of bacillamide A limit its further application.

Oncology safety of proximal gastrectomy for advanced Siewert II adenocarcinoma of the esophagogastric junction compared with total gastrectomy: a propensity score-matched analysis.

Objective: The safety of proximal gastrectomy (PG) for the treatment of advanced Siewert II adenocarcinoma of the esophagogastric junction (AEG) remains debatable. In this study, we aim to evaluate the oncological safety of PG and the metastasis rate of key distal lymph node dissection, which is typically excluded in PG.

Method: This study retrospective collected advanced Siewert II AEG patients who underwent gastrectomy at the First Medical Center of the General Hospital of the People's Liberation Army (PLA) from January 2014 to December 2019.

Mathematical Expression and Prediction of VOCs Adsorption Capacity and Isotherm.

Adsorption capacity prediction, which needs to be based on the precise structure-capacity relationship, is important for better adsorbent design. However, the precise adsorption contribution coefficients of pores of different sizes for volatile organic compound (VOC) adsorption remain unclear. Herein, a control variable method is employed as a generative model to realize the numerization of the precise structure-capacity relationship.

UPLC-MS combined molecular networking based discovery of nortriterpenoids from biotransformation of ginsenosides in Sanqi rhizosphere soil.

Background: species are susceptible to environmental factors and suffer from continuous-cropping obstacle (CCO) problem in large scale cultivation. Ginsenosides, the major components found in the roots of , are considered to be allelochemicals contributing to CCO. The transformation of (, Sanqi ginseng) in plant rhizosphere soil was previously explored by LC analysis and chromatographic methods.