Applying machine learning techniques to predict the risk of distant metastasis from gastric cancer: a real world retrospective study.

Background: Distant metastasis of gastric cancer can seriously affect the treatment strategy of gastric cancer patients, so it is essential to identify patients at high risk of distant metastasis of gastric cancer earlier.

Method: In this study, we retrospectively collected research data from 18,472 gastric cancer patients from the SEER database. We applied six machine learning algorithms to construct a model that can predict distant metastasis of gastric cancer.

Kinetic modeling of sulfonamide degradation by UV/HO: Deduction of R modeling and application.

Eight sulfonamide (SA) antibiotics were effectively degraded using a UV/HO process in a quasi-collimated beam apparatus, utilizing optimized fluence quantification. Fluence-based rate constants (kk') for the UV/HO process were established. A curve-fitting method, derived from R modeling, was developed for the UV/HO process to quantitatively assess the impact of critical factors, including water quality and direct UV photolysis.

Synthesis of Mo-Pt/CeO Dual Single-Atom Nanozyme for Multifunctional Biochemical Detection Applications.

Elaborated structural modulation of Pt-based artificial nanozymes can efficiently improve their catalytic activity and expand their applications in clinical diagnosis and biochemical sensing. Herein, a highly efficient dual-site peroxidase mimic composed of highly dispersed Pt and Mo atoms is reported. The obtained Mo-Pt/CeO exhibits exceptional peroxidase-like catalytic activity, with a V as high as 34.

Study on Explosion Characteristics and Mechanism of Electrostatic Spray Powder.

In order to fully understand the explosion risk of electrostatic spraying powder, corresponding preventive measures are put forward. The explosion characteristics, ignition sensitivity, and flame propagation of three typical electrostatic spraying powders were tested using a 20 L spherical explosion test device, a G-G furnace test device, and a Hartmann tube test device, and the explosion process and mechanism of electrostatic spraying powders were discussed. The results show that the maximum explosion pressure and the maximum explosion pressure rise rate increase first and then decrease with the increase in mass concentration.

Quenching residual HO from UV/HO with granular activated carbon: A significant impact of bicarbonate.

UV/HO has been used as an advanced oxidation process to remove organic micropollutants from drinking water. It is essential to quench residual HO to prevent increased chlorine demand during chlorination/chloramination and within distribution systems. Granular activated carbon (GAC) filter can quench the residual oxidant and eliminate some of the dissolved organic matter.

Research on the Inhibition Effect of NaCl on the Explosion of Mg-Al Alloy Powder.

A study was conducted on the explosion overpressure and flame propagation law of magnesium-aluminum (Mg-Al) alloy powder, and the suppression mechanism of sodium chloride (NaCl) on the explosion of magnesium-aluminum alloy powder was explored. Adding NaCl powder can effectively reduce the explosion pressure, flame front position, and flame propagation speed. The higher the amount of NaCl powder added, the lower the explosion pressure of magnesium-aluminum alloy powder, the slower the flame propagation speed, and the lower the flame brightness.

Cananga oil inhibits Salmonella infection by mediating the homeostasis of purine metabolism and the TCA cycle.

Ethnopharmacology Relevance: Cananga oil (CO) is derived from the flowers of the traditional medicinal plant, the ylang-ylang tree. As a traditional antidepressant, CO is commonly utilized in the treatment of various mental disorders including depression, anxiety, and autism. It is also recognized as an efficient antibacterial insecticide, and has been traditionally utilized to combat malaria and acute inflammatory responses resulting from bacterial infections both in vitro and in vivo.

Corrigendum: The immune factors have complex causal regulation effects on inflammatory bowel disease.

[This corrects the article DOI: 10.3389/fimmu.2023.

The immune factors have complex causal regulation effects on inflammatory bowel disease.

Background: Although a correlation between immune cell phenotypes and inflammatory bowel disease (IBD) has been established, a causal relationship remains unestablished.

Methods: To assess causal associations between immune cell phenotypes and IBD and its subtypes, we employed Mendelian randomization (MR) methods and genome-wide association studies (GWAS) summary statistics. The primary outcomes were determined based on the inverse variance weighting (IVW) results, with the assessment of heterogeneity and pleiotropy conducted through Cochrane's Q-test and MR-Egger.

Designing a Hybrid Chain Reaction Probe for Multiplex Transcripts Assay with High-Level Imaging.

The hybrid chain reaction (HCR), an isothermal and enzyme-free amplification strategy, has found extensive use in fluorescent hybridization (FISH) assays. However, the existing HCRs are limited, being time-consuming processes and low-efficiency imaging due to weak signal, significantly restricting their application in transcriptomic assays. To address the limitations, we developed nine orthogonal HCR hairpin-pair (hp) probes in this study to enable efficient signal amplification for multiplex assays.

Gut microbiota and common gastrointestinal diseases: a bidirectional two-sample Mendelian randomized study.

Background: Several recent studies have shown an association between gut microbiota and gastrointestinal diseases. However, the causal relationship between gut microbiota and gastrointestinal disorders is unclear.

Methods: We assessed causal relationships between gut microbiota and eight common gastrointestinal diseases using Mendelian randomization (MR) analyses.

Comparative transcriptome profile analysis of granulosa cells from porcine ovarian follicles during early atresia.

At various stages of ovarian follicular development, more than 99% of follicles will be eliminated through a degenerative process called atresia. The regulatory mechanisms of atresia have been elucidated to some extent, involving hormones, growth factors, cytokines, and other factors. However, the stimuli initiating atresia in follicular granulosa cells remain unknown.

Ethanol-diluted turbidimetry method for rapid and accurate quantification of low-density microplastics in synthetic samples.

Retention and transport behaviours of microplastics (MPs) and their associated pollutants in porous media are of great concern. The homogeneity of the studied MPs in artificially controlled lab-scale studies makes rapid and accurate MP quantification feasible. In this study, an economical ethanol-diluted turbidimetry method for polypropylene (PP) and polyethylene (PE) MPs was developed.

A machine learning-based model for predicting distant metastasis in patients with rectal cancer.

Background: Distant metastasis from rectal cancer usually results in poorer survival and quality of life, so early identification of patients at high risk of distant metastasis from rectal cancer is essential.

Method: The study used eight machine-learning algorithms to construct a machine-learning model for the risk of distant metastasis from rectal cancer. We developed the models using 23867 patients with rectal cancer from the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2017.

Application of machine learning techniques in real-world research to predict the risk of liver metastasis in rectal cancer.

Background: The liver is the most common site of distant metastasis in rectal cancer, and liver metastasis dramatically affects the treatment strategy of patients. This study aimed to develop and validate a clinical prediction model based on machine learning algorithms to predict the risk of liver metastasis in patients with rectal cancer.

Methods: We integrated two rectal cancer cohorts from Surveillance, Epidemiology, and End Results (SEER) and Chinese multicenter hospitals from 2010-2017.

Effective Quality Breeding Directions-Comparison and Conservative Analysis of Hepatic Super-Enhancers between Chinese and Western Pig Breeds.

The transcriptional initiation of genes is closely bound to the functions of -regulatory elements, including promoters, typical enhancers (TEs), and recently-identified super-enhancers (SEs). In this study, we identified these -regulatory elements in the livers of two Chinese (Meishan and Enshi Black) and two Western (Duroc and Large White) pig breeds using ChIP-seq data, then explored their similarities and differences. In addition, we analyzed the conservation of SEs among different tissues and species (pig, human, and mouse).

Computational fluid dynamics modelling of quasi-collimated beam apparatus - a typical bench scale UV apparatus for water treatment.

Quasi-collimated beam apparatus (QCBA), a typical bench scale UV apparatus, is crucial for the biodosimetry determination of UV dose in target reactors. However, the key parameters for the QCBA construction are usually estimated via rule-of-thumb calculations. Computational fluid dynamics models are applied in this study to simulate the UV fluence rate (FR) distributions in QCBAs.

Effect of low-intensity ultrasound on partial nitrification: Performance, sludge characteristics, and properties of extracellular polymeric substances.

Ultrasound technology, which is environment-friendly and economical, has emerged as a novel strategy that can be used to enhance the partial nitrification process. However, its effect on this process remains unclear. Therefore, in this study, partial nitrification sludge was subjected to low-intensity (0.

Enhanced fluorescence and heat dissipation of calcium titanate red phosphor based on silver coating.

Phosphor plays an important role in LEDs-the next generation of lighting source. However, many families of phosphor like titanate still face two severe problems: Low photoluminescence (PL) efficiency and poor thermal stability. Herein, the silver coating is applied to alleviate the above challenges.