[Evaluation of taste changes of Scutellariae Radix before and after wine-frying based on electronic ongue technology and its application in identification of Scutellariae Radix pieces].

Scutellariae Radix(Huangqin) is a well-known traditional Chinese medicine(TCM) used for the treatment of clearing heat in clinical application. It is bitter-cold by using directly, but the bitter-cold property can be relieved after wine-frying. The study of taste changes before and after wine-frying of Scutellariae Radix is of great significance in identifying Scutellariae Radix and wine-processed Scutellariae Radix and clarifying the traditional theory of wine-processing.

MicroRNA‑383‑5p inhibits the proliferation and promotes the apoptosis of gastric cancer cells by targeting cancerous inhibitor of PP2A.

The aberrant expression of microRNA (miRNAor miR)‑383‑5p has been found in numerous types of cancer. However, the function of miR‑383‑5p in gastric cancer (GC) remains elusive and requires further investigation. In the present study, the level of miR‑383‑5p and cancerous inhibitor of PP2A (CIP2A) in GC cell lines was determined by reverse transcription‑quantitative PCR analysis.

Phacoemulsification in vitrectomized eyes: Maintaining the stability of the anterior chamber via a new technique.

Fluctuating anterior chamber depth and reverse pupillary block are the most common problems encountered during phacoemulsification following pars plana vitrectomy in cases of cataracts. The sudden deepening of the anterior chamber makes the surgical procedure more cumbersome and increases the risk of intraoperative complications. To solve this problem, we describe a method of balancing the pressure of the anterior and posterior chamber by using a syringe with a flushing needle to inject balanced salt solution into the posterior chamber via the gap between the iris and the anterior capsule of the lens.

Preparation of gold nanorod-incorporated monolith for solid phase extraction of polycyclic aromatic hydrocarbons.

An organic-inorganic hybrid monolithic column doped with gold nanorods (AuNRs) was prepared and evaluated for solid phase extraction (SPE) of polycyclic aromatic hydrocarbons (PAHs). Excellent dispersibility of AuNRs in binary green porogen system consisting of 1-hexyl-3-methylimidazolium tetrafluoroborate and deep eutectic solvents (DESs) was confirmed by energy dispersive spectrometry (EDS). The particle size of the resulting AuNRs (70-90 nm) was thoroughly examined by a transmission electron microscopy (TEM).

A High-Precision Magnetic-Assisted Heading Angle Calculation Method Based on a 1D Convolutional Neural Network (CNN) in a Complicated Magnetic Environment.

Due to its widespread presence and independence from artificial signals, the application of geomagnetic field information in indoor pedestrian navigation systems has attracted extensive attention from researchers. However, for indoors environments, geomagnetic field signals can be severely disturbed by the complicated magnetic, leading to reduced positioning accuracy of magnetic-assisted navigation systems. Therefore, there is an urgent need for methods which screen out undisturbed geomagnetic field data for realizing the high accuracy pedestrian inertial navigation indoors.

Cardiovascular Outcomes Post Percutaneous Coronary Intervention in Patients with Obstructive Sleep Apnea and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Introduction: Type 2 diabetes mellitus (T2DM) is a major risk factor for the occurrence of cardiovascular diseases. Similar to T2DM, obstructive sleep apnea (OSA) is also known to be a risk factor for cardiovascular diseases. In this analysis, we aimed to systematically compare the post-interventional cardiovascular outcomes observed in patients with T2DM with versus without OSA.

Molecular Surveillance and in vitro Drug Sensitivity Study of Isolates from the China-Myanmar Border.

The emergence and spread of resistance in to the frontline treatment artemisinin-based combination therapies in Southeast Asia require close monitoring of the situation. Here, we collected 36 clinical samples of from the China-Myanmar border in 2014-2016, adapted these parasites to continuous culture, and performed in vitro drug assays on seven antimalarial drugs. Data for 23 parasites collected in 2010 and 2012 from the same area reported in an early study were used to assess longitudinal changes in drug sensitivity.

Resonant-Cantilever-Detected Kinetic/Thermodynamic Parameters for Aptamer-Ligand Binding on a Liquid-Solid Interface.

Nucleic acid aptamers have been widely used as recognition elements on various biosensing interfaces, but quantitative kinetic/thermodynamic analysis for revealing the aptamer-ligand binding mechanism, which occurs on a liquid-solid interface, has not been realized due to a lack of usable biophysical tools. Herein we apply a resonant microcantilever sensor to continuously record the frequency shift according to the binding-induced mass change on the liquid-solid interface. The frequency-shift curve is used for tracing the reaction process and is fitted with classic equations to calculate a set of kinetic/thermodynamic parameters, such as rate constants ( = 902.

Resistance effect of flavonols and toxicology analysis of hexabromocyclododecane based on soil-microbe-plant system.

The toxicity characteristics of HBCD and resistance mechanism of flavonols are investigated based on physiological and metagenomic analysis. Toxicology research of HBCD on Arabidopsis thaliana (Col and fls1-3) not only shows the toxic effect of HBCD on plants, but also indicates that flavonols could improve plant resistance to HBCD, including root length, shoot biomass and chlorophyll content. Analysis of eggNOG and GO enrichment demonstrates that HBCD has toxic effect on both gene expression and protein function, which concentrates on energy production - conversion and amino acid transport - metabolism.

Integrated response of growth, antioxidant defense and isotopic composition to microplastics in juvenile guppy (Poecilia reticulata).

Microplastics (MPs) pollution becomes a research hotspot and many studies focus on threats of MPs, but few have integrated multi-level indicators to assess response to MPs of organisms. Here we exposed guppy (Poecilia reticulata) to MPs (polystyrene; 32-40 μm diameter) with two concentrations (100 and 1000 μg/L) for 28 days. We found that higher accumulation of MPs appeared in guppy gill than that in gut.

7,8-Dihydroxyflavone Attenuates Alcohol-Related Behavior in Rat Models of Alcohol Consumption via TrkB in the Ventral Tegmental Area.

Alcohol use disorder (AUD) is a ubiquitous substance use disorder in the world, of which neural mechanisms remain unclear. Alcohol consumption induces neuro-adaptations in the dopaminergic system originating from the ventral tegmental area (VTA), an important brain region for the reward function in AUD. Endogenous brain-derived neurotrophic factor (BDNF)-TrkB implicated in the development of neuroplasticity, including long-term potentiation of GABAergic synapses (LTP ).

Extreme-Pressure Superlubricity of Polymer Solution Enhanced with Hydrated Salt Ions.

The development of new routes or materials to realize superlubricity under high contact pressure can result in energy-saving and reduction of emissions. In this study, superlubricity (μ = 0.0017) under extreme pressure (717 MPa, more than twice the previously reported liquid superlubricity) between the frictional pair of SiN/sapphire was achieved by prerunning-in with a HPO (HP) solution followed by lubrication with an aqueous solution consisting of poly(vinyl alcohol) (PVA) and sodium chloride (NaCl).

Notch-Hes1 Signaling Regulates IL-17A T Cell Expression and IL-17A Secretion of Mouse Psoriasis-Like Skin Inflammation.

Purpose: To evaluate the regulating effect of Notch-Hes1 signaling on IL-17A T cell expression and IL-17A secretion in mouse psoriasis-like skin inflammation.

Materials And Methods: Experimental mice were randomly divided into control group, model group (5% imiquimod- (IMQ-) treated mice), and intervention group (IMQ and -secretase inhibitor DAPT cotreated mice). The severity of psoriasis-like skin inflammation was evaluated by target lesion score based on the clinical psoriasis area and severity index (PASI).

Antibacterial and antioxidant activities of sodium starch octenylsuccinate-based Pickering emulsion films incorporated with cinnamon essential oil.

This study aimed to determine the potential of sodium starch octenylsuccinate (SSOS)-based Pickering emulsions incorporated with cinnamon essential oil (CEO) as a vehicle for delivering active biodegradable films to improve their antimicrobial and antioxidant activites. This study explored the combined effects of mixed oils (CEO and corn oils). Particle size distribution, mean drop size, ζ-potential, polymer dispersity index (PDI), and microstructure were determined to confirm emulsion stability.

MicroRNA-33a negatively regulates myoblast proliferation by targeting IGF1, follistatin and cyclin D1.

MiR-33a is found as a regulator of cell proliferation in many cancer cells. However, it remains unknown if and how miR-33a plays a role in myoblast proliferation. To investigate the effect of miR-33a on myoblast proliferation, miR-33a mimic or inhibitor was co-administered with or without insulin-like growth factor 1 (IGF1) to simulation myoblasts.

Prognostic and diagnostic value of circRNA expression in colorectal carcinoma: a meta-analysis.

Background: Circular RNAs (circRNAs) are research hotspots in the network of noncoding RNAs in numerous tumours. The purpose of our study was to evaluate the clinicopathological, prognostic and diagnostic value of circRNAs in colorectal cancer.

Methods: The PubMed, Cochrane Library, and Web of Science online databases were searched for relevant studies before May 15, 2019.

Efficient mucosal vaccination of a novel classical swine fever virus E2-Fc fusion protein mediated by neonatal Fc receptor.

Classical swine fever (CSF) remains one of the most important highly contagious and fatal viral disease of swine with high morbidity and mortality. CSF is caused by classical swine fever virus (CSFV), a small, enveloped RNA virus of the genus Pestivirus. The aim of this study was to construct the a novel CSFV Fc-fusion recombinant protein and evaluate the efficacy as a vaccine against CSFV.

TMEM98 mRNA promotes proliferation and invasion of gastric cells by directly interacting with NF90 protein.

Transmembrane protein 98 (TMEM98) is a recently discovered gene, the inhibition of which has preliminarily been demonstrated to inhibit progression of several solid cancers in vitro. However, its involvement in tumorigenesis of gastric cancer (GC) has not been reported. Here, we aimed to explore the expression of TMEM98 in GC tissues and cell lines and to determine the role of TMEM98 in GC cell proliferation and invasion.

The Diagnostic Value of Serum L1CAM in Patients With Colorectal Cancer.

Objective: Colorectal cancer is one of the most important malignant cancer in the world with high incidence and mortality. Some studies have found that the expression of low serum L1 cell adhesion molecule is associated with poor prognosis in some malignancies. It is suggested that L1 cell adhesion molecule is a candidate serum marker for certain tumors.

Oven-Controlled MEMS Oscillator with Integrated Micro-Evaporation Trimming.

This study reports an oven-controlled microelectromechanical systems oscillator with integrated micro-evaporation trimming that achieves frequency stability over the industrial temperature range and permanent frequency trimming after vacuum packaging. The length-extensional-mode resonator is micro-oven controlled and doped degenerately with phosphorous to achieve a frequency instability of ±2.6 parts per million (ppm) in a temperature range of -40 to 85 °C.

Toxicity, migration and transformation characteristics of lead in soil-plant system: Effect of lead species.

Lead (Pb) is a typical hazardous element of high concern in species characteristics involving toxicity, migration and transformation. A greenhouse experiment was conducted using Solanum nigrum L. grown in soils treated by divalent (Pb), tetravalent (Pb), trimethyl (TML) and triethyl (TEL) lead for 60 days.

Diagnostic performance of circulating exosomes in human cancer: A meta-analysis.

Background: Cancer has become a public health problem with high morbidity and mortality. Recent publications have shown that exosomes can be used as potential diagnostic biomarkers of cancer. However, the diagnostic accuracy and reliability of circulating exosomes remain unclear.

Emerging Role of TRIM Family Proteins in Cardiovascular Disease.

Ubiquitination is one of the basic mechanisms of cell protein homeostasis and degradation and is accomplished by 3 enzymes, E1, E2, and E3. Tripartite motif-containing proteins (TRIMs) constitute the largest subfamily of RING E3 ligases, with >70 current members in humans and mice. These members are involved in multiple biological processes, including growth, differentiation, and apoptosis as well as disease and tumorigenesis.

Combined effects of electrical current and nonsteroidal antiinflammatory drugs (NSAIDs) on microbial community in a three-dimensional electrode biological aerated filter (3DE-BAF).

Three-dimensional electrode biological aerated filter (3DE-BAF) with particulate bioelectrode from lithium slag was used to simultaneously remove diclofenac and clofibric acid from the synthetic domestic sewage, and the combined effects of electrical current and nonsteroidal antiinflammatory drugs (NSAIDs) on microbial community was analyzed. The results indicated that (1) the average diclofenac and clofibric acid removal efficiency in the 3DE-BAF firstly increased, attained the peak of 79.40 ± 6.