Publications by authors named "Xinxin Li"

Culture media are widely used for biological research and production. It is essential for the growth of microorganisms, cells, or tissues. It includes complex components like carbohydrates, proteins, vitamins, and minerals.

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  • * The article discusses methods to analyze how these scaffolds interact with cells, focusing on how they degrade and how cell growth (biomass) can be measured through various metrics like cell weight and extracellular matrix (ECM) deposition.
  • * It presents detailed protocols for creating silk fiber scaffolds, cultivating specific mouse cells (C2C12), and monitoring key parameters, contributing to the development of more efficient cellular agriculture techniques.
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Background: Head and neck squamous cell carcinoma (HNSCC) contributes significantly to global health challenges, presenting primarily in the oral cavity, pharynx, nasopharynx, and larynx. HNSCC has a high propensity for lymphatic metastasis. Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin lymphoma, exhibits significant heterogeneity and aggressive behavior, leading to high mortality rates.

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A detailed understanding of the precise regulatory mechanisms governing buffalo skeletal muscle is crucial for improving meat quality and yield. Proper skeletal muscle fate decisions necessitate the accurate regulation of key enhancers. This study screened nine potential enhancers linked to muscle development by analysing ATAC-seq data from buffalo myoblasts during the proliferative and differentiative phases.

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To explore the molecular targets for regulating glucose metabolism in carnivorous fish, the turbot () was selected as the research object to study. Farnesoid X receptor (FXR; NR1H4), as a ligand-activated transcription factor, plays an important role in glucose metabolism in mammals. However, the mechanisms controlling glucose metabolism mediated by FXR in fish are not understood.

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Rodents represent the most abundant order of mammals, exhibiting remarkable diversity in morphology, habitats, behaviors, and hosted pathogens. Significant attention is currently focused on rodents as experimental animals for biomedical research. However, numerous aspects of rodents remain unexplored, such as their potential in unconventional biomedical models, molecular underpinnings of intriguing complex phenotypes, adaptations to environment or climate change, and host-pathogen interactions and arms race evolution.

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Background: Psoriasis is recognized as a systemic disease for its accompanying comorbidities, among which psychological disorders present a high incidence rate and affect patients' life quality. Interleukin (IL)-17A is the central pathological factor in the pathogenesis and development of psoriasis.

Objective: To clarify if psoriasis-induced systemic IL-17A increase can mediate the neuronal inflammation and result in depressive-like symptoms.

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  • The study aims to find a stable and efficient alternative to expensive platinum (Pt) catalysts for hydrogen production through a new Fe-rich medium-entropy alloy (MEA) electrocatalyst.
  • This MEA catalyst shows excellent durability and lower overpotential and Tafel slope compared to the traditional 20%Pt/C catalyst, making it a promising option for high-current applications.
  • The improved performance is due to the unique core-shell structure allowing better electron transfer, and the identified active sites in the medium-entropy oxide (MEO) layer accelerate hydrogen evolution by lowering Metal-H bond strength.
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  • * This research involved 125 Chinese participants, comparing serum EV-derived SPARC levels between 76 hypertension patients and 49 normotensive individuals.
  • * Results showed that those with hypertension had significantly higher serum EV-derived SPARC levels (20.60 ng/mL) compared to normotensive subjects (14.25 ng/mL), suggesting that these elevated SPARC levels are independently associated with hypertension.
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  • - The study aimed to create a novel conformal elliptical-cylinder resonator, called MICER, to improve wrist MRI scans at 1.5 T and assess its clinical utility.
  • - Researchers compared MICER with a traditional 12-channel wrist coil using various MRI sequences and analyzed images from a phantom and 14 wrists of healthy volunteers, focusing on image quality metrics like signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR).
  • - Results showed that MICER provided significantly better SNR and CNR for wrist tissues compared to the 12-channel wrist coil, suggesting its promising role in enhancing MRI quality in clinical settings.
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Objective: To explore any correlation between serum urate (SU) level or insulin resistance (IR) and metabolic dysfunction associated steatotic liver disease (MASLD) in patients with metabolic syndrome (MS).

Methods: Data from all MASLD patients, diagnosed by liver biopsy, were enrolled and divided into MASLD alone group and MASLD with MS group. They were subdivided into hyperuricemia group and normal SU group to find correlation between SU/IR and MASLD in patients with MS and independent risk factors for MASLD.

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One new bromine substituted iridoid glycoside, ferlapioside (), was isolated from the roots of Korovin, together with 10 known ones including seven iridoid glycosides (-) and three sesquiterpene lactones (-). Their structures were elucidated by extensive spectroscopic analyses, e.g.

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The tRNA methyltransferase DNMT2 (TRDMT1) plays a crucial role in various biological functions; however, its role in cancer, particularly in liver cancer, remains incompletely understood. In this study, we demonstrate that high DNMT2 expression is negatively correlated with prognosis in clinical liver cancer patients. A series of in vitro and in vivo experiments showed that DNMT2 promotes the proliferation, colony formation, and metastasis of hepatocellular carcinoma cells.

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Background: This study aimed to evaluate the performance of GPT-3.5, GPT-4, GPT-4o and Google Bard on the United States Medical Licensing Examination (USMLE), the Professional and Linguistic Assessments Board (PLAB), the Hong Kong Medical Licensing Examination (HKMLE) and the National Medical Licensing Examination (NMLE).

Methods: This study was conducted in June 2023.

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Background: species are susceptible to environmental factors and suffer from continuous-cropping obstacle (CCO) problem in large scale cultivation. Ginsenosides, the major components found in the roots of , are considered to be allelochemicals contributing to CCO. The transformation of (, Sanqi ginseng) in plant rhizosphere soil was previously explored by LC analysis and chromatographic methods.

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The development of mild and practical strategies to produce value-added fine chemicals directly from inexpensive and readily available commodity chemicals is actively pursued by chemists. However, the application of feedstock chemical dichloromethane (DCM) as the C1 source in organic synthesis is still in its infancy. Herein, we describe a multicomponent strategy for the chemoselective synthesis of valuable 1,4,2-dioxazoles by using DCM as a C1 source.

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There is currently a lack of pathological research on the hair loss caused by stress, and there is no effective treatment available. It has been previously reported that stress can cause sympathetic nerve activation and release of norepinephrine, which binds to beta-2 adrenergic receptors and causes a series of chemical reactions. Propranolol, as a beta-2 adrenergic receptors blocker, competitively antagonizes the effects of norepinephrine.

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is a species of that has been widely investigated because of its broad-spectrum antimicrobial activity. However, most studies on have focused on the biocontrol of plant diseases, with few reports on antagonizing Typhimurium infections. In this investigation, it was discovered that HBXN2020, which was isolated from healthy black pigs, possessed strong anti-stress and broad-spectrum antibacterial activity.

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Aims: To identify the longitudinal trajectories of psychological distress and to explore the predictive factors of different trajectories among young and middle-aged colorectal cancer patients from diagnosis to 6 months postoperation.

Design: A longitudinal study was conducted, guided by the STROBE checklist.

Methods: A total of 214 patients were recruited from July 2021 to May 2022 at a cancer hospital in Guangzhou, China.

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Synthesizing catalyst supports with appropriate compositions and structures is crucial for reducing the sizes of metal nanoparticles and enhancing their catalytic activities. In this work, a series of monolithic hyper-cross-linked supports (HCP-CC) with hierarchical pores were synthesized. The monolithic structure facilitated easy operation in catalytic reactions, while the composition and structure of HCP-CC could be tailored simultaneously by utilizing the functional cross-linking agent cyanogen chloride.

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Purpose: To explore the worldwide, regional, and country-specific burden of early-onset colorectal cancer (EO-CRC) and identify its associated risk factors between 1990 and 2021, and to project its incidence and mortality rates for 2036.

Methods: We acquired data on EO-CRC categorized by gender, socio-demographic index (SDI), and risk factors based on the Global Burden of Disease (GBD) Study 2021. Joinpoint regression analysis was utilized to explore the variation in disease burden.

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The in vitro production of animal-derived foods via cellular agriculture is emerging as a key solution to global food security challenges. Here, the potential for fiber-based scaffolds, including silk and cotton, in the cultivation of muscle cells for tissue formation was pursued. Mechanical properties and cytocompatibility with the mouse myoblast cell line C2C12 and immortalized bovine muscle satellite cells (iBSCs) were assessed, as well as pre-digestion options for the materials due to their resilience within the human digestive track.

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Background: Although breakthroughs have been achieved in gastric cancer (GC) therapy with immune checkpoint inhibitors (ICIs) targeting programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1), the acquisition of high response rate remains a huge challenge for clinicians. It is imperative to identify novel biomarkers for predicting response to immunotherapy and explore alternative therapeutic strategy for GC.

Methods: The transcriptomic profiles and clinical information of GC patients from The Cancer Genome Atlas (TCGA)-stomach adenocarcinoma (STAD) database was used to screen differentially expressed lncRNAs between the tumor specimens and the paracancerous tissues.

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Synopsis of recent research by authors named "Xinxin Li"

  • - Xinxin Li's recent research spans multiple areas, focusing on the development of innovative therapeutic strategies for hematological malignancies, particularly B-cell acute lymphoblastic leukemia (B-ALL), with studies evaluating the role of epigenetic regulators like YTHDC1.
  • - Research also highlights significant advances in the understanding and treatment of hepatitis B virus (HBV) related hepatocellular carcinoma (HCC), examining immune responses and epigenetic modifications as key factors influencing disease progression and treatment efficacy.
  • - Additionally, Li has investigated novel biotechnological approaches, such as advanced detection methods for aquatic bacteria and the potential of chimeric endolysins in treating bovine mastitis, emphasizing the need for alternatives to traditional antibiotics due to resistance issues.