Publications by authors named "Xinxin Guo"

Introduction: Increased intracranial pressure (ICP) is common with viral encephalitis in children which is associated with complications and prognosis. The optic nerve sheath diameter (ONSD) is a new indicator for the assessment of intracranial pressure using ultrasound, CT scan and MRI imaging. Given the influence of physical development on ONSD size in children, we expect more accurate assessment of intracranial pressure with ONSD/ETD (eyeball transverse diameter) ratio by ultrasound.

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Lack of efficient biomarkers and clinical translation of molecular typing impedes the implementation of targeted therapy for hepatocellular carcinoma (HCC). High-throughput sequencing techniques represented by next-generation sequencing (NGS) are tools for detecting targetable genes. The objective of this study is to explore the genetic alterations associated with clinicopathological features and the risk of recurrence/metastasis in HCC.

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  • The study focuses on intrahepatic cholestasis of pregnancy (ICP), a liver disorder common during pregnancy, and explores its genetic causes specifically in East Asian populations compared to Europeans.
  • Researchers conducted a large genome-wide association study on serum bile acids and ICP in over 98,000 Chinese pregnancies, identifying new genetic loci linked to the disorder and its risk.
  • The findings suggest a unique genetic link to ICP in East Asians tied to historical hepatitis B epidemics, which could lead to improved detection and treatment strategies for the condition.
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Hyperuricemia is a known risk factor for chronic kidney disease (CKD) and subsequent renal fibrosis. N6-methyladenosine (m6A) is the most prevalent chemical modification in eukaryotic mRNAs and has been implicated in various diseases. However, its role in hyperuricemic nephropathy (HN) remains unclear.

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This retrospective study assessed the efficacy of initial treatment with intravenous immunoglobulin (IVIG), aspirin, and corticosteroids in Kawasaki disease (KD) patients at risk for IVIG resistance. Data from pediatric patients with KD between January 2010 and December 2019 were divided into the IVIG-sensitive and IVIG-resistant groups based on treatment response. Risk factors for IVIG resistance were identified through univariate analysis.

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  • Maintaining normal thyroid function in pregnancy is essential, as thyroid dysfunction affects a notable percentage of pregnant women, prompting a study on the genetic basis of thyroid traits among 85,421 Chinese participants.
  • The research identified 176 genetic loci linked to thyroid traits, including 125 novel associations, revealing connections between thyroid function and various health outcomes, including gestational complications and birth outcomes.
  • Findings indicate that higher levels of thyroid-stimulating hormone (TSH) during pregnancy are associated with positive metabolic effects and that thyroid-related genetics may inform future healthcare strategies for preventing disorders later in life.
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Cracks are a common problem in concrete surfaces. With the continuous optimization of machine vision-based inspection systems, effective crack detection and recognition is the core of the entire system. In this study, support vector machine (SVM) was used to distinguish cracks from other regions.

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N-Nitrosamine disinfection by-products (NAs-DBPs) have been well proven for its role in esophageal carcinogenesis. However, the role of intratumoral microorganisms in esophageal squamous cell carcinoma (ESCC) has not yet been well explored in the context of exposure to NAs-DBPs. Here, the multi-omics integration reveals () as "facilitators" is highly enriched in cancer tissues and promotes the epithelial mesenchymal transition (EMT)-like subtype formation of ESCC.

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Evidence of the associations between long-term exposure to PM and O and human blood lipid concentrations is abundant yet inconclusive. Whether clean air policies could improve lipid profiles remains unclear. In total, 2979312 participants from a Chinese nationwide prospective study were included.

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  • Primary familial brain calcification (PFBC) is a genetic neurological disorder with no current effective treatment, linked to mutations in the SLC20A2 gene.
  • Researchers identified five new genetic variants in the SLC20A2 gene that disrupt normal splicing of its pre-mRNA, leading to dysfunctional protein production.
  • The use of splice-switching antisense oligonucleotides (ASOs) not only helped restore functional SLC20A2 expression in affected cells but also showed promise in reducing brain calcification and controlling phosphorus levels in animal models, highlighting a potential therapeutic approach for PFBC.
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Backgrounds: Cognitive problems are common symptoms among individuals with stress-related exhaustion. It is still unknown whether these individuals are at a higher risk of developing dementia later. This study aims to examine the relationship between midlife stress-related exhaustion and dementia incidence.

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  • - Chlortoluron (CTU), an herbicide used in agriculture, is harmful to aquatic life, prompting this study to investigate its metabolism and liver toxicity.
  • - The study identified several metabolites produced from CTU in liver microsomes, including a benzylic alcohol (M1) and various conjugates that indicate further metabolic processing.
  • - CTU was found to be cytotoxic to rat liver cells, and the enzyme CYP3A4 was identified as key in its metabolic activation, while the antifungal ketoconazole reduced the cells’ vulnerability to CTU toxicity.
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Assembling small molecules at liquid/solid interfaces is relatively common and contributes to many unique properties of the interface. However, such an assembling process can be dynamic depending on the concentration of the molecule and the properties of the solid and liquid themselves, which poses serious challenges on the accurate evaluation of the assembling processes. Herein, we report a convenient way for in situ and real-time monitoring of assembling-disassembling of small-molecule surfactants on the surface of microchannels using pulsed streaming potential (SP) measurement based on the variation of surface charge.

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Background: The cancer microbiota was considered the main risk factor for cancer progression. We had proved that Fusobacterium periodonticum (F.p) was higher abundance in Esophageal cancer(EC)tissues.

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  • InGaAs detection systems are essential in aerospace applications, needing precise evaluation methods due to high signal-to-noise ratio demands for infrared payloads.
  • The study introduces a neural network-based approach to predict the scattering parameters of rigid-flex printed circuit boards (PCBs), which significantly affect weak infrared signals.
  • Utilizing simulated samples, the neural network model demonstrated over 99% accuracy in predictions, improving design efficiency and quality for InGaAs detection circuits.
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Background: Longitudinal studies are essential to understand the ageing process, and risk factors and consequences for disorders, but attrition may cause selection bias and impact generalizability. We describe the 1930 cohort of the Gothenburg H70 Birth Cohort Studies, followed from age 70 to 88, and compare baseline characteristics for those who continue participation with those who die, refuse, and drop out for any reason during follow-up.

Methods: A population-based sample born 1930 was examined with comprehensive assessments at age 70 ( = 524).

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Trace metal zinc is involved in key processes of solid tumors by its antioxidant properties, while the role of zinc at the onset of esophageal squamous cell carcinoma (ESCC) remains controversial. This study aimed to determine whether zinc is associated with the ESCC and underlying molecular events involving malignant progression. Based on a case-control study, we found serum and urine zinc were decreased and correlated with ESCC progression.

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Background And Aims: Observational studies have implicated the involvement of gut microbiome in stroke development. Conversely, stroke may disrupt the gut microbiome balance, potentially causing systemic infections exacerbated brain infarction. However, the causal relationship remains controversial or unknown.

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  • Intensified sanitation during the SARS-CoV-2 outbreak may increase chloramine disinfectants in water, leading to harmful nitrosamine disinfection by-products (DBPs) that can damage DNA and potentially cause cancer.
  • Nitrosamine DBPs are linked to metabolic disorders, chronic inflammation, and tumor initiation, and they interfere with important metabolic processes like tryptophan metabolism and DNA repair.
  • Current research is lacking in fully understanding the toxic effects and mechanisms of nitrosamine DBPs, underscoring the need for further studies in cancer biology and tumor metabolomics.
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Obesity has become a major disease that endangers human health. Studies have shown that dietary interventions can reduce the prevalence of obesity and diabetes. Resistant starch (RS) exerts anti-obesity effects, alleviates metabolic syndrome, and maintains intestinal health.

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Explicitly sharing individual level data in genomics studies has many merits comparing to sharing summary statistics, including more strict QCs, common statistical analyses, relative identification and improved statistical power in GWAS, but it is hampered by privacy or ethical constraints. In this study, we developed encG-reg, a regression approach that can detect relatives of various degrees based on encrypted genomic data, which is immune of ethical constraints. The encryption properties of encG-reg are based on the random matrix theory by masking the original genotypic matrix without sacrificing precision of individual-level genotype data.

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  • * A genome-wide association study (GWAS) was conducted on participants who received COVID-19 vaccines, revealing that certain human leukocyte antigen (HLA) alleles, particularly HLA-DRB113:02, are associated with better antibody responses.
  • * The findings highlight the role of specific genetic factors in vaccine response and suggest that understanding these variations can help improve vaccination strategies for better protection against COVID-19 across different populations.
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Platelet count reduction occurs throughout pregnancy, with 5% to 12% of pregnant women being diagnosed with gestational thrombocytopenia (GT), characterized by a more marked decrease in platelet count during pregnancy. However, the underlying biological mechanism behind these phenomena remains unclear. Here, we used sequencing data from noninvasive prenatal testing of 100 186 Chinese pregnant individuals and conducted, to our knowledge, the hitherto largest-scale genome-wide association studies on platelet counts during 5 periods of pregnancy (the first, second, and third trimesters, delivery, and the postpartum period) as well as 2 GT statuses (GT platelet count < 150 × 109/L and severe GT platelet count < 100 × 109/L).

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  • Immune checkpoint inhibitors (ICIs) paired with anti-angiogenic drugs can have effective anti-cancer effects, but they may also lead to immune-mediated hepatitis (IMH).
  • A study analyzed 100 IMH patients to compare the severity of liver injury between those treated with ICIs alone and those treated with a combination of ICIs and anti-angiogenic therapy.
  • The results indicated no significant increase in overall liver injury severity with the combination therapy; however, certain types of liver inflammation were more pronounced in the combination group, while treatment outcomes remained similar between both groups.
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