Nitrogenation of Alkynes with Nitrones to Prepare Functionalized [1,4]Oxazinones through Csp-Csp Bond Cleavage.

Herein, we report a novel strategy of hypervalent iodine(III) compound-mediated selective C-C bond cleavage of alkynes and C═N/N-O bond cleavage of nitrones and recombination of C-C/C-O/C-N multiple bonds to access various functionalized [1,4]oxazinones bearing a vicinal carbon stereocenter in good yields and high diastereoselectivity. Mechanistic studies revealed that the reaction undergoes a domino [4 + 3] cycloaddition, 1,3-rearrangement of N-O bond, intramolecular cyclization, dearomatization, and rearomatization over four steps in a single flask. The present method features good functional group tolerance, broad substrate scope, and C-C/C═N/N-O multiple bonds cleavage and recombination.

Biomass-derived O, N-codoped hierarchically porous carbon prepared by black fungus and for high performance supercapacitor.

Biomass-derived carbon materials have been widely researched due to their advantages such as low cost, environmental friendliness, readily available raw materials. Black fungus and contain many kinds of amino acids. In this paper, unique O, N-codoped black fungus-derived activated carbons (FAC ), and -derived activated carbons (HAC ) were prepared by KOH chemical activation under different temperatures without adding additional reagents containing nitrogen and oxygen functional groups, respectively.

Tailoring Functional Terminals on Solution-Processable Fullerene Electron Transporting Materials for High Performance Perovskite Solar Cells.

Widely known as an excellent electron transporting material (ETM), pristine fullerene C plays a critical role in improving the photovoltaic performance of inverted structure perovskite solar cells (PSCs). However, the imperfect perovskite/C interface significantly limits the promotion of device performance and stability due to the weak coordination interactions between bare carbon cages and perovskite. Here, we designed and synthesized three functionalized fulleropyrrolidine ETMs (abbreviated as CEP, CEPE, and CECB), each of which was modified with the same primary terminal (cyanoethyl) and various secondary terminals (phenyl, phenethyl, and chlorobutyl).

Self-anti-angiogenesis nanoparticles enhance anti-metastatic-tumor efficacy of chemotherapeutics.

Beyond traditional endothelium-dependent vessel (EDV), vascular mimicry (VM) is another critical tumor angiogenesis that further forms in many malignant metastatic tumors. However, the existing anti-angiogenesis combined chemotherapeutics strategies are only efficient for the treatment of EDV-based subcutaneous tumors, but remain a great challenge for the treatment of in situ malignant metastatic tumor associated with EDV and VM. Here, we demonstrate a self-assembled nanoparticle (VE-DDP-Pro) featuring self-anti-EDV and -VM capacity enables to significantly enhance the treatment efficacy of cisplatin (DDP) against the growth and metastasis of ovarian cancer.

A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy.

Existing nanoparticle-mediated drug delivery systems for glioma systemic chemotherapy remain a great challenge due to poor delivery efficiency resulting from the blood brain barrier/blood-(brain tumor) barrier (BBB/BBTB) and insufficient tumor penetration. Here, we demonstrate a distinct design by patching doxorubicin-loaded heparin-based nanoparticles (DNs) onto the surface of natural grapefruit extracellular vesicles (EVs), to fabricate biomimetic EV-DNs, achieving efficient drug delivery and thus significantly enhancing antiglioma efficacy. The patching strategy allows the unprecedented 4-fold drug loading capacity compared to traditional encapsulation for EVs.

Mixed Fullerene Electron Transport Layers with Fluorocarbon Chains Assembling on the Surface: A Moisture-Resistant Coverage for Perovskite Solar Cells.

In structure perovskite solar cells (PSCs), the most prevalent electron transport layer (ETL), [6, 6]-phenyl-C-butyric acid methyl ester (PCBM), acts as both electron extractor and protective coverage to the underlayer perovskite. Notably, multifunctional mixed fullerene ETLs show great potential in further improving both the power conversion efficiency (PCE) and stability of PSCs compared to the single PCBM ETL. In this work, we reported the mixed fullerene ETLs comprising of PCBM and its two analogs with different length of fluorocarbon chains, [6, 6]-phenyl-C-buryric acid 1H,1H-trifluoro-1-ethyl ester (abbreviated, CF-PCBM) and [6, 6]-phenyl-C-buryric acid 1H, 1H-tridecafluoro-1-heptyl ester (abbreviated, CF-PCBM).