Stain transformation using Mueller matrix guided generative adversarial networks.

Recently, virtual staining techniques have attracted more and more attention, which can help bypass the chemical staining process of traditional histopathological examination, saving time and resources. Meanwhile, as an emerging tool to characterize specific tissue structures in a label-free manner, the Mueller matrix microscopy can supplement more structural information that may not be apparent in bright-field images. In this Letter, we propose the Mueller matrix guided generative adversarial networks (MMG-GAN).

Stereoscopic spatial graphical method of Mueller matrix: Global-Polarization Stokes Ellipsoid.

A Mueller matrix covers all the polarization information of the measured sample, however the combination of its 16 elements is sometimes not intuitive enough to describe and identify the key characteristics of polarization changes. Within the Poincaré sphere system, this study achieves a spatial representation of the Mueller matrix: the Global-Polarization Stokes Ellipsoid (GPSE). With the help of Monte Carlo simulations combined with anisotropic tissue models, three basic characteristic parameters of GPSE are proposed and explained, where the V parameter represents polarization maintenance ability, and the E and D parameters represent the degree of anisotropy.

Bioinformatic Analysis of the Significance of the KIR2DL4 Gene in Recurrent Implantation Failure.

Related studies have pointed out that Killer immunoglobulin-like receptor 2DL4 (KIR2DL4) was associated with vascular remodeling in early pregnancy, and it might play an important role in immunity. In this study, recurrent implantation failure (RIF)-related GSE58144 dataset was extracted from the Gene Expression Omnibus (GEO) database. Firstly, the immune micro-environment analyses were conducted to analyze the pathogenesis of KIR2DL4 in RIF.

The UCA1 and microRNA-18a signaling pathway mediates the irisin-lowering effect of metformin in the management of polycystic ovary syndrome.

Introduction: The present study aimed to clarify the underlying mechanism of metformin (met) in the management of polycystic ovary syndrome (PCOS) and to explore the role of the UCA1/microRNA-18a signaling pathway in the control of PCOS.

Material And Methods: Real-time PCR was performed to compare the levels of irisin, blood glucose, UCA1 and miR-18a among PCOS, PCOS + Met, and control groups using area under curve (AUC) values. In-silicon analysis and luciferase assay were performed to explore the regulatory relationship among UCA1, miR-18a and irisin.

Comparison of dexmedetomidine with propofol as sedatives for pediatric patients undergoing magnetic resonance imaging: A meta-analysis of randomized controlled trials with trial sequential analysis.

Dexmedetomidine and propofol are commonly used sedative agents in pediatric patients undergoing magnetic resonance imaging (MRI). The present meta-analysis aimed to compare dexmedetomidine with propofol in pediatric patients undergoing MRI using trial sequential analysis (TSA). The PubMed, Cochrane Library and Web of Knowledge databases were systematically searched for entries up to August 2018 for potential randomized controlled trials comparing dexmedetomidine with propofol in pediatric patients undergoing MRI.

Does pre-scanning training improve the image quality of children receiving magnetic resonance imaging?: A meta-analysis of current studies.

Background: Magnetic resonance imaging (MRI) is often used in children for its clear display of body parts. But it is usually hard to acquire high-quality images, for the uncooperative ability of children. It is believed that pre-MRI training could ensure the high quality of images.

Correlation of CT signs with lymphatic metastasis and pathology of neuroblastoma in children.

Correlation between computed tomography (CT) signs, lymphatic metastasis and pathological features of neuroblastoma (NB) in children was investigated. A total of 374 child patients diagnosed with NB via CT scan and pathological section in Department of Pediatric of Xuzhou Children's Hospital from March 2011 to January 2017 were collected, and their clinical data were retrospectively analyzed. According to CT signs, NB calcification and invasion to surrounding tissues were evaluated, and the tumor site, tumor size, lymphatic metastasis, pathological types and clinical prognosis were analyzed.

Abnormal irisin level in serum and endometrium is associated with metabolic dysfunction in polycystic ovary syndrome patients.

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive-age women. Irisin is considered to play a role in metabolic disorder and PCOS. However, correlation between irisin and metabolic disorder in PCOS is not clear.

Dexmedetomidine versus propofol on the sedation of pediatric patients during magnetic resonance imaging (MRI) scanning: a meta-analysis of current studies.

Magnetic resonance imaging (MRI) is a widely applied diagnostic approach for detection of pediatric diseases. Sedatives are commonly used to acquire the accurate MRI images. Dexmedetomidine and propofol serve as sole or combined sedatives in pediatric MRI scanning.

MRI features of growth hormone deficiency in children with short stature caused by pituitary lesions.

We verified the advantages of using magnetic resonance imaging (MRI) for improving the diagnostic quality of growth hormone deficiency (GHD) in children with short stature caused by pituitary lesions. Clinical data obtained from 577 GHD patients with short stature caused by pituitary lesions were retrospectively analyzed. There were 354 cases (61.

Magnetic resonance imaging in pediatric sickle cell anemia.

Sickle cell disease is the result of altered genetic make up due to hereditary encounter and its form as homozygous sickle cell anemia is the most common and severe. The disease is characterized by chronic anemia, recurrent pain crises and vascular occlusion. Neurologically, there is a high incidence of stroke in childhood, as well as cognitive dysfunction.

[Transformation of biphenyl intermediate metabolite by manganese peroxidase from a white rot fungus SQ01].

Objective: To understand the biochemical role of white rot fungus Trametes sp. SQ01 manganese peroxidase (MnP) towards 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoates (HOPDA)/HOPDA derivatives and to reveal the new catalytic features of MnP, white rot fungus Trametes sp. SQ01 MnP was extracted, and the purified enzymes were used in the oxidation of HOPDAs.

Use of MRI and CT image indexing to assess cerebral injuries in neonates with hypoxic-ischemic encephalopathy.

Background: The aim of this study is to explore the application of magnetic resonance imaging (MRI) and computed tomography (CT) image indexing in the assessment of cerebral injury of hypoxic-ischemic encephalopathy (HIE) neonate.

Methods: The clinical data of 100 HIE children, who were admitted to the Department of Radiology, Xuzhou Children's Hospital, Jiangsu, from June 2013 to June 2014, were statistically analyzed.

Results: Among the imaging data of 100 HIE children, the detection rate and false negative rate were 91.

[Changes of lung, spleen and kidney aquaporin-1 in rats with Kidney Yang Deficiency: the "water metabolism theory" in traditional Chinese medicine].

Objective: To explore the experimental basis of the "water metabolism theory" in traditional Chinese medicine by observing the changes of aquaporin-1 in the lung, spleen and kidney.

Methods: Rat models of Kidney Yang Deficiency induced by gavage with 2% adenine suspension for 4 weeks were treated with cistanches decoction for 6 weeks. Urinary 17-hydroxy cortisol, urine creatinine, urine osmolality value content, and aquaporin-1 mRNA and protein expressions in the lung, spleen and kidney tissues were detected after the treatment.