Publications by authors named "Xinwu Lu"

ObjectivesProximal to mid-term effects of contrast excimer laser atherectomy (ELA) + drug-coated balloon (DCB) versus PTA + drug-coated balloon (DCB) in the treatment of new lesions in the femoral popliteal segment of patients with lower extremity arteriosclerosis and occlusion.MethodsThe clinical data of 105 patients with CT-confirmed femoropopliteal segment lesions (Rutherford grades 3-6) were retrospectively analyzed. According to the computerized randomization method, 58 patients (44 males, mean 72.

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Objectives: Aortic dissection (AD) is a life-threatening condition that requires intensive care and management. This paper explores the role of fluid management in the clinical care of AD patients, which has been unclear despite the substantial existing research that has been conducted on the treatment of AD.

Design: A retrospective case-control study using data for AD patients from public databases.

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Infrared (IR) photodetectors play a crucial role in modern technologies due to their ability to operate in various environmental conditions. This study developed high-performance InSe/GaAs interdiffusion heterostructure photodetectors with broadband response using liquid-phase method. It is believed that an InGaAs layer and InSe have been formed at the interface through the mutual diffusion of elements, resulting in a detection spectral range spanning from 0.

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Iliac Vein Compression Syndrome (IVCS) is a common risk factor for deep vein thrombosis in the lower extremities. The objective of this study was to investigate whether employing a porous medium model to simulate the compressed region of an iliac vein could improve the reliability and accuracy of Computational Fluid Dynamics (CFD) analysis outcomes of IVCS. Pre-operative Computed Tomography (CT) scan images of patients with IVCS were utilized to reconstruct models illustrating both the compression and collateral circulation of the iliac vein.

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Intraluminal prosthetic graft thrombus (IPT) has been described in case of endovascular aortic pathology repair. This study aimed to assess hemodynamic indicators associated with various anatomical morphologies following endovascular aortic repair (EVAR), aiming to offer further references for the choice of clinical therapy. Six model models (normal, iliac compression, aortic compression, aortoiliac compression, iliac distortion, and long-leg stent) were established based on common anatomical morphologies following EVAR.

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Purpose: To evaluate whether endovascular therapy (ET) improved early symptom relief and decreased the incidence of moderate-to-severe postthrombotic syndrome (PTS) compared with anticoagulation alone in patients with subacute (15-28 days) iliofemoral deep vein thrombosis (DVT).

Materials And Methods: Consecutive patients with subacute iliofemoral DVT from January 2020 to June 2022 were identified. A total of 86 patients were assigned to receive treatment with ET alongside anticoagulation (endovascular group, n = 49) or anticoagulation alone (anticoagulation group, n = 37).

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Abdominal aortic aneurysm (AAA) is a chronic inflammation-driven disease characterized by aortic wall destruction and expansion, leading to high morbidity and mortality. However, previous drug treatments for its common risk factors have not achieved favorable results, and the early prevention and treatment is still the main clinical dilemma. Anti-inflammation therapy is a promising therapeutical method targeting its pathogenesis mechanism, but it has not been explored in depth.

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Biomaterial-assisted therapeutic strategies enable precise modulation to direct endogenous cellular responses and harness regenerative capabilities for nerve repair. However, achieving effective cellular engagement during nerve remodeling remains challenging. Herein, a novel composite nerve guidance conduit (NGC), the GelMA/PLys@PDA-Fe@PLCL conduit is developed by combining aligned poly(l-lactide-co-caprolactone) (PLCL) nanofibers modified with polydopamine (PDA), ferrous iron (Fe⁺), and polylysine (PLys) with aligned methacrylate-anhydride gelatin (GelMA) hydrogel nanofibers.

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The abdominal aortic aneurysm (AAA) is a severe and complex condition characterized by the pathological dilation of the abdominal aorta. Current therapeutic strategies are limited, with surgical repair being the most effective intervention due to the lack of medications that can slow aneurysmal expansion or prevent adverse events. In this study, an innovative nanoplatform, Mn-UiO-66-NH@HA, designed to repair vascular smooth muscle cells (VSMCs), and the extracellular matrix (ECM) is developed, thereby enhancing arterial wall integrity.

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Atherosclerosis is the main pathogenic factor of various cardiovascular diseases. During the pathogenesis of atherosclerosis, macrophages play a major role, mainly by secreting pro-inflammatory cytokines and taking in lipids to form foam cells. Thiamine pyrophosphate (TPP) is an antagonist of the P2Y6 receptor, which is overexpressed on macrophages during atherosclerosis and facilitates the lipid phagocytosis of macrophages.

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Objective: Whether high-density lipoprotein cholesterol (HDL-C) has a protective role against abdominal aortic aneurysm (AAA) development in both older males and females remains uncertain. This study aims to assess the sex-specific association between HDL-C and incident AAA in older adults from the UK Biobank.

Methods: This cohort study included 86,184 males and 95,682 females aged ≥60 years from the UK biobank.

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The objective of this research is to analyze the hemodynamic differences in five configurations of left subclavian artery (LSA) stent grafts after LSA endovascular reconstruction in thoracic endovascular aortic repair (TEVAR). For numerical simulation, one three-dimensional thoracic aortic geometry model with an LSA stent graft retrograde curved orientation was reconstructed from post-TEVAR computed tomography angiography (CTA) images, and four potential LSA graft configurations were modified and reconstructed: three straight (0, 2, and 10 mm aortic extension) and one anterograde configuration. The blood perfusion of the LSA, flow field, and hemodynamic wall parameters were analyzed.

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Purpose: This study aims to summarize the experience and outcomes of using 3D printing technology to assist physician-modified fenestrated-branched endovascular aortic repair (PM-FBEVAR) in the treatment of thoracoabdominal aortic dissection involving visceral branches.

Materials And Methods: From December 2018 to May 2023, clinical data of 48 consecutive patients (35 males; mean age, 62.9±11.

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Diabetic limb ischemia (DLI) is a frequent complication of diabetes and the leading cause of non-traumatic amputation. Traditional treatments like stent placement and bypass surgery may not suit all patients. Exosome transplantation has emerged as a promising therapy.

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Background: Despite appropriate treatment, up to 50% of patients with proximal deep vein thrombosis will develop postthrombotic syndrome (PTS). Once PTS occurs, there is no specific treatment, and some patients constantly experience intolerable symptoms. Hence, prevention of PTS is important.

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Background: This study aims to determine the efficacy and safety of preoperative embolization in the management of Shamblin type III carotid body tumors (CBT).

Method: In this retrospective study, patients with Shamblin type III CBT were included between January 2005 and January 2017. A total of 48 Patients were divided into preoperative embolization (SRE, n = 25) and non-preoperative embolization group (SR, n = 23).

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Article Synopsis
  • The study investigates the geometric features of the thoracic aorta to identify a morphological marker for aortic dissection (AD).
  • It analyzes CT angiograms from 63 AD patients and 71 healthy individuals, using a fitting circle method to compare aortic shapes.
  • Results reveal that the thoracic aorta in healthy subjects resembles a circle more closely than in AD cases, indicating that aortic deformation can serve as a significant indicator of aortic dissection.
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Article Synopsis
  • Aortic dissection (AD) is a critical emergency with high risks, and this study aimed to find factors that predict in-hospital death for patients in the ICU.
  • Researchers used data from ICU admissions and employed various methods like logistic regression and machine learning to create predictive models based on patient information.
  • The study identified key factors influencing mortality, such as initial blood pressure and average fluid intake over 24 hours, and found that the random forest model performed best in predicting outcomes.
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Background: A stent with characteristics of a hybrid design may have advantages in improving the patency of symptomatic iliofemoral vein obstruction. This study assessed the safety and effectiveness of the V-Mixtent Venous Stent in treating symptomatic iliofemoral outflow obstruction.

Methods: Eligible patients had a Clinical-Etiologic-Anatomic-Physiologic (CEAP) C classification of ≥ 3 or a Venous Clinical Severity Score (VCSS) pain score of ≥ 2.

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Abdominal aortic aneurysm (AAA) is a common and potentially life-threatening condition. Chronic aortic inflammation is closely associated with the pathogenesis of AAA. Nerve injury-induced protein 1 (NINJ1) is increasingly acknowledged as a significant regulator of the inflammatory process.

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Article Synopsis
  • * It finds that silencing DRP1 and using the treatment isoliquiritigenin (ISL) can reduce the adverse effects of diabetes on VSMCs, such as heightened oxidative stress and cell proliferation.
  • * ISL works by directly binding to a specific site on DRP1, decreasing its activity related to mitochondrial fission, and ultimately mitigating intimal hyperplasia in diabetic models.
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Article Synopsis
  • Vascular calcification (VC) in diabetes is driven by the switching of vascular smooth muscle cells to an osteogenic phenotype, which can be mitigated by mitophagy, a process that cleans up damaged mitochondria.
  • This study evaluates how the GLP-1 receptor agonist exendin 4 (EX4) impacts mitophagy-related phenotype switching in VSMCs, using T2DM mice models and cultured human cells under high glucose conditions.
  • EX4 was found to enhance mitophagy, improve mitochondrial function, and activate the AMPK signaling pathway, which collectively reduced VC in diabetic mice and inhibited the problematic osteogenic differentiation of VSMCs.
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Background: Endovenous interventions and minimally invasive procedures are effective in the management of varicose veins. However, they can cause postoperative discomfort.

Objective: To evaluate the clinical efficacy of sodium aescinate (SA) in improving edema, pain, vein-specific symptoms, and quality of life in patients following endovenous laser ablation (EVLA) for varicose veins.

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Introduction: Prevention of recurrence after an episode of venous thromboembolism (VTE), and also the post-thrombotic syndrome (PTS), is still a recognised challenge. In this meta-analysis, we will summarise existing evidence to compare intelligent system follow-up and routine follow-up for patients with VTE.

Methods And Analysis: Relevant randomised controlled trials (RCTs) and cohort studies will be included from the following databases: MEDLINE/PubMed, Web of Science and the Cochrane Library.

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Article Synopsis
  • Iliofemoral deep vein thrombosis (IFDVT) can cause severe symptoms, and while endovascular thrombectomy and stenting help, venous in-stent restenosis (ISR) has emerged as a significant issue.
  • A study evaluated the histological differences in neointima of patients with arterial and venous ISR, finding a collagen-rich but less cellular structure in venous cases, and assessed the effectiveness of using a paclitaxel-coated balloon for treatment.
  • Results showed significant reduction in stenosis degree after intervention and improvements in patients' quality of life scores without major adverse events, suggesting drug-coated balloons are a safe and effective option for treating venous ISR in I
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