Publications by authors named "Xinwen Sheng"
Article Synopsis
- Temporal lobe epilepsy (TLE) is a common neurological disorder that many patients struggle with due to resistance to standard treatments, and research suggests that acetylcholine may play a significant role in its development and persistence.
- This study investigated the effects of tropisetron, a drug known for treating nausea in cancer patients, on TLE in rats, demonstrating that it reduced the frequency of seizures, improved memory, and mitigated damage in the hippocampus.
- The results suggest that tropisetron works by enhancing cholinergic signaling through α7 nicotinic acetylcholine receptors, highlighting its potential as a therapeutic option for TLE, although its effects can be blocked by specific antagonists.
Article Synopsis
- * A study using a rat model induced with lithium-pilocarpine examined changes in the hippocampus, revealing 27 differentially expressed proteins related to synaptic plasticity and structure after 2 weeks of spontaneous seizures.
- * Findings showed significant upregulation of certain proteins and increased dendritic spines, suggesting that synaptic remodeling plays a key role in the development of TLE, offering insights for further research on synaptic plasticity in this condition.
Temporal lobe epilepsy (TLE) is a common chronic neurological disease that is often invulnerable to anti-epileptic drugs. Increasing data have demonstrated that acetylcholine (ACh) and cholinergic neurotransmission are involved in the pathophysiology of epilepsy. Cytisine, a full agonist of α7 nicotinic acetylcholine receptors (α7nAChRs) and a partial agonist of α4β2nAChRs, has been widely applied for smoking cessation and has shown neuroprotection in neurological diseases.
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