Introduction: This study aimed to evaluate the pharmacokinetics (PK), safety, and local tolerability of local finasteride spray (0.25% solution in HPCH, once daily, volume 200 μL) after single and multiple doses in Chinese male volunteers with androgenetic alopecia.
Methods: Twelve male patients with androgenetic alopecia received once-daily scalp application of the solution for 7 days.
Background: Left-right (LR) asymmetry disorders present a complex etiology, with genetic factors emerging as a primary contributor. This study aims to explore the genetic underpinnings of chromosomal variants and individual genes in fetuses afflicted with prenatal LR asymmetry disorder.
Methods: Through a retrospective analysis conducted between 2020 and 2023 at Tongji Hospital, Huazhong University of Science and Technology, genetic outcomes of LR asymmetric disorder were scrutinized utilizing copy number variation sequencing (CNV-seq) and whole exome sequencing (WES) methodologies.
P-phenylenediamine antioxidants (PPDs) are widely used in the rubber industry and their release and transformation in the environment has become one of the current environmental research hotspots. PPDs are readily oxidized in the environment to form quinone transformation products (PPD-Qs), some of which (e.g.
View Article and Find Full Text PDFThe increasing prevalence of plastic pollution has led to widespread environmental concerns, particularly with microplastics (MPs) that persist in various ecosystems. As MPs accumulate in terrestrial environments, their potential impact on plant health and agricultural productivity has become a growing area of focus. This study presents a comprehensive meta-analysis evaluating the effects of MPs on plant physiological and biochemical parameters, synthesizing data from 37 studies comprising 2886 observations.
View Article and Find Full Text PDFMicrobial remediation of heavy metal (HM)-contaminated soil is a sustainable approach; however, the impact of microbial inoculation on the internal environment of plants remains understudied. Thus, Enterobacter sp. FM-1 (Enterobacter sp.
View Article and Find Full Text PDFIntroduction: Programmed cell death (PCD) is a fundamental biological process crucial for plant development. Despite recent advancements in our understanding of PCD's molecular mechanisms, the intricate orchestration of this process within plant cells remains enigmatic. To address this knowledge gap, the present study focuses on , a plant species renowned for its unique fruit anatomy, including laticiferous canals that secrete latex.
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
May 2024
The title compound, CHNO, was obtained by the de-acetyl-ation reaction of 1-(6-amino-5-nitro-naphthalen-2-yl)ethanone in a concentrated sulfuric acid methanol solution. The mol-ecule comprises a naphthalene ring system bearing an acetyl group (C-3), an amino group (C-7), and a nitro group (C-8). In the crystal, the mol-ecules are assembled into a two-dimensional network by N⋯H/H⋯N and O⋯H/H⋯O hydrogen-bonding inter-actions.
View Article and Find Full Text PDFMicroplastics (MPs) and antibiotic resistance genes (ARGs) are two types of contaminants that are widely present in the soil environment. MPs can act as carriers of microbes, facilitating the colonization and spread of ARGs and thus posing potential hazards to ecosystem safety and human health. In the present study, we explored the microbial networks and ARG distribution characteristics in different soil types (heavy metal (HM)-contaminated soil and agricultural soil planted with different plants: Bidens pilosa L.
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
March 2024
The title compound, CHNO, was obtained from 2-acetyl-6-amino-naphthalene through two-step reactions of acetyl-ation and nitration. The mol-ecule comprises the naphthalene ring system consisting of functional systems bearing a acetyl group (C-2), a nitro group (C-5), and an acetyl-amino group (C-6). In the crystal, the mol-ecules are assembled into two-dimensional sheet-like structures by inter-molecular N-H⋯O and C-H⋯O hydrogen-bonding inter-actions.
View Article and Find Full Text PDFis a frequently cultivated ornamental plant containing several secondary metabolites, including alkaloids, flavonoids, and volatile organic compounds (VOCs). However, extensive research has been conducted only on non-VOCs found in the plant, whereas the production of VOCs and the molecular mechanisms underlying the biosynthesis of terpenes remain poorly understood. In this study, 17 volatile compounds were identified from flowers using gas chromatography-mass spectrometry (GC-MS), with 16 of them being terpenoids.
View Article and Find Full Text PDFInflammatory skin diseases are a group of diseases caused by the disruption of skin tissue due to immune system disorders. Histone modification plays a pivotal role in the pathogenesis and treatment of chronic inflammatory skin diseases, encompassing a wide range of conditions, including psoriasis, atopic dermatitis, lupus, systemic sclerosis, contact dermatitis, lichen planus, and alopecia areata. Analyzing histone modification as a significant epigenetic regulatory approach holds great promise for advancing our understanding and managing these complex disorders.
View Article and Find Full Text PDFAchieving rapid, efficient, and cost-effective anaerobic digestion (AD) of food waste is a key means to improve the efficiency of food waste treatment. However, in view of the shortage of historical anaerobic digestion data, the limitation of general neural networks in predicting biogas production, and its sensitivity to abnormal variation points, achieving accurate prediction of biogas production is not easy. This paper proposes a novel biogas production prediction model of food waste AD for energy optimization based on the mixup data augmentation integrating an improved global attention mechanism long short-term memory (LSTM).
View Article and Find Full Text PDFPolyethylene (PE) microplastics are emerging pollutants that pose a significant threat to the environment and human health. However, little is known about the effects of PEs on soil‒plant interactions, especially in heavy metal (HM)-contaminated soil. In this study, the effects of PE on rhizosphere soil enzyme activities, microbial interactions and nutrient cycling processes were analyzed from ecological network and functional gene perspectives for the first time.
View Article and Find Full Text PDFObjective: Spinal muscular atrophy (SMA) is an autosomal recessive disorder mainly affecting the neuromuscular system, which seriously threatens the life and health of patients. But few studies have reported the acceptance rate of SMA gene screening and SMA carrier rate in China. The present study aimed to clarify the two issues in China through a retrospective analysis of 18,818 reproductive age women in Wuhan area of China.
View Article and Find Full Text PDFBackground: Fetal skeletal dysplasia is a diverse group of degenerative diseases of bone and cartilage disorders that can lead to movement disorder and even death. This study aims to evaluate the diagnostic yield of sonographic examination and genetic testing for fetal skeletal dysplasia.
Methods: From September 2015 to April 2021, the study investigated 24 cases with suspected short-limb fetuses, which were obtained from Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology.
Objectives: Juvenile dermatomyositis (JDM) is a chronic autoimmune disease. Some patients remain in an active state even though they were administrated with a combination of corticosteroid and methotrexate. Existing research has suggested that interferon and Janus kinase played an important role in pathogenesis.
View Article and Find Full Text PDFBidens pilosa L. (B. pilosa) has great potential for the phytoremediation of cadmium (Cd)-contaminated soils.
View Article and Find Full Text PDFEnterobacter sp. are widely used in bioremediation, but the mechanism of Cadmium (Cd) toxicity in Enterobacter sp. has been poorly studied.
View Article and Find Full Text PDFTourism destinations are the important research objects of tourism geography. And destination songs, as a media of tourism destination image, play a very important role in it. Based on the SOR model, this study constructs a theoretical relationship between destination song perception and tourism intention.
View Article and Find Full Text PDFSoil deficiency, cyclic erosion, and heavy metal pollution have led to fertility loss and ecological function decline in mining areas. Fertilization is an important way to rapidly replenish soil nutrients, which have a major influence on the soil nitrogen cycling process, but different fertilization regimes have different impacts on soil properties and microbial functional potentials. Here, metagenomic sequencing was used to investigate the different responses of key functional genes of microbial nitrogen cycling to fertilization regimes and explore the potential effects of soil physicochemical properties on the key functional genes.
View Article and Find Full Text PDFMetagenomics analysis was performed to determine the effects of Enterobacter sp. FM-1 (FM-1) on key genera as well as functional genes in the rhizosphere of Bidens pilosa L. (B.
View Article and Find Full Text PDFThis study introduced whole-exome sequencing (WES) in prenatal diagnosis of fetal bowel dilatation to improve the detection outcome when karyotype analysis and copy number variation sequencing (CNV-seq) were uninformative in detecting pathogenic variants. The work reviewed 28 cases diagnosed with fetal bowel dilatation and analyzed the results of karyotype analysis, CNV-seq, and WES. Among the 28 cases, the detection rate in cases with low risk of aneuploidy was 11.
View Article and Find Full Text PDFExtracellular polymeric substances (EPSs) are macromolecular polymers formed by metabolic secretion, and they have great potential for removing heavy metal (HM) ions from the aquatic phase. In this study, the contributions of soluble EPSs (S-EPSs), loosely bound EPSs (LB-EPSs) and tightly bound EPSs (TB-EPSs) secreted by Enterobacter sp. to Cd and Pb adsorption were analyzed.
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