TQFL19, a Novel Derivative of Thymoquinone (TQ), Plays an Essential Role by Inhibiting Cell Growth, Metastasis, and Invasion in Triple-Negative Breast Cancer.

Breast cancer (BC) is a significant public health concern globally. Triple-negative breast cancer (TNBC) is considered the most challenging type, as it is defined by an absence of estrogen and progesterone receptor expression, along with a lack of HER2 overexpression. In the current study, we developed a novel thymoquinone (TQ), TQFL19, to control TNBC progression.

The Optimized Lipid-Modified Prodrug for CNV Treatment.

Choroidal neovascularization (CNV) is a prevalent cause of vision impairment. The primary treatment for CNV involves intravitreal injections of anti-vascular endothelial growth factor antibodies. Nevertheless, this approach still faces numerous limitations like poor patient compliance, high therapy expenditure and lack of response in some individuals.

Associations With Adverse Postoperative Outcomes in Children Undergoing Atrial Septal Defect Closure in Lower-Resource Settings.

Background: Atrial septal defects (ASDs) are a common cause of congenital heart disease worldwide.

Objectives: The purpose of the study was to assess change over time in surgical outcomes for ASD repair and identify patient-level risk factors for adverse postoperative outcomes.

Methods: We analyzed cases of isolated ASD in patients <18 years from 2010 to 2020 from 71 sites participating in the International Quality Improvement Collaborative for Congenital Heart Disease.

Daytime variation of in-hospital mortality and low cardiac output syndrome after pediatric cardiac surgery-a retrospective cohort study.

Objective: Recent studies suggest that adult cardiac surgery performed in the morning increases the risk of major adverse cardiac events, but it is unclear whether this association exists in pediatric cardiac surgery. This study aimed to determine whether the composite outcome of in-hospital mortality and low cardiac output syndrome (LCOS) differs between morning and afternoon pediatric cardiac surgeries.

Methods: This retrospective cohort study enrolled 23,433 consecutive pediatric patients who underwent cardiac surgery between August 2014 and December 2021.

Tracheoplasty should be proactively considered in the surgical strategy for treating the ring-sling complex.

Objective: To examine the safety and effectiveness of proactive tracheoplasty for pediatric ring-sling complex.

Methods: We retrospectively collected data from 304 children who were diagnosed with a ring-sling complex and underwent surgery at 3 cardiac centers in China between January 2010 and June 2023. The children were categorized into 3 surgical groups: concurrent sling and tracheal surgery (group A; n = 258), staged sling and tracheal surgery (group B; n = 25), and sling-only surgery (group C; n = 21).

Preoperative Malnutrition Increases Risk of In-Hospital Mortality, Major Infection, and Longer Intensive Care Unit Stay After Ventricular Septal Defect Closure.

Background: High energy requirements and poor feeding can lead to growth failure in patients with ventricular septal defect (VSD), but effects of preoperative malnutrition on surgical outcomes are poorly understood, especially in low-resource settings.

Methods And Results: We analyzed a cohort of children <5 years of age undergoing VSD closure at 60 global centers participating in the International Quality Improvement Collaborative for Congenital Heart Disease, 2015 to 2020. We calculated adjusted odds ratios (ORs) for in-hospital death and major infection and adjusted coefficients for duration of intensive care unit stay for 4 measures of malnutrition: severe wasting (weight-for-height score, <-3), moderate wasting (-3 View Article and Find Full Text PDF

Tricuspid mechanical valve replacement for severe tricuspid stenosis in a child who underwent surgical correction of complete atrioventricular septal defect, a rare long-term complications.

Background: Complete atrioventricular septal defect is a complicated congenital heart malformations, and surgical correction is the best treatment, the severe tricuspid stenosis is a rare long-term complication after the surgery.

Case Presentation: We report a case with the complication of severe tricuspid stenosis 7 years after the surgical correction of complete atrioventricular septal defect in a child. Then the patient underwent tricuspid mechanical valve replacement, Glenn, atrial septostomy, and circumconstriction of the right pulmonary artery.

Machine learning prediction model of major adverse outcomes after pediatric congenital heart surgery: a retrospective cohort study.

Background: Major adverse postoperative outcomes (APOs) can greatly affect mortality, hospital stay, care management and planning, and quality of life. This study aimed to evaluate the performance of five machine learning (ML) algorithms for predicting four major APOs after pediatric congenital heart surgery and their clinically meaningful model interpretations.

Methods: Between August 2014 and December 2021, 23 000 consecutive pediatric patients receiving congenital heart surgery were enrolled.

Risk factors of gastrointestinal bleeding after cardiopulmonary bypass in children: a retrospective study.

Background: During cardiac surgery that involved cardiopulmonary bypass (CPB) procedure, gastrointestinal (GI) system was known to be vulnerable to complications such as GI bleeding. Our study aimed to determine the incidence and risk factors associated with GI bleeding in children who received CPB as part of cardiac surgery.

Methods: This retrospective study enrolled patients aged <18 years who underwent cardiac surgery with CPB from 2013 to 2019 at Shanghai Children's Medical Center.

Poly(ether ether ketone) Conferred Polyolefin Separators with High Dimensional Thermal Stability for Lithium-Ion Batteries.

The traditional polyolefin separators used in lithium-ion batteries (LIBs) are plagued by limitations such as poor wetting of electrolytes and insufficient thermal stability, hindering the progress of LIBs. To overcome these limitations, we have developed a modified phase inversion technique to efficiently and durably coat polyolefin separators with poly(ether ether ketone) (PEEK). The resulting PEEK-coated polyolefin separators exhibit mechanical properties similar to those of unmodified polyolefin separators, with comparable tensile strength and modulus.

Morphologic classification of tracheobronchial arborization in children with congenital tracheobronchial stenosis and the associated cardiovascular defects.

Background: We sought to classify patients with congenital tracheal stenosis (CTS) according to tracheobronchial morphology and determine anatomic features associated with tracheobronchial anomalies (TBAs) and concurrent cardiovascular defects (CVDs).

Methods: We enrolled 254 patients who underwent tracheoplasty between November 1, 2009 and December 30, 2018. The anatomic features of the tracheobronchial tree and cardiovascular system were abstracted from bronchoscopy, echocardiography, computerized tomography, and operative reports.

H filter-based dynamic joint carrier frequency offset and linear phase noise tracking for CO-OFDM systems.

In this paper, a robust, dynamic and joint carrier frequency offset (CFO) and linear phase noise (LPN) tracking algorithm is proposed by utilizing the H filter for CO-OFDM systems. The dynamic tracking is implemented by Bayesian filtering which time-recursively updates the posterior state estimates based on the prior state information and calculated gain. To improve the robustness of the dynamic tracking process against the uncertainty of the noise terms, we adopt the H filter, which designs a min-max optimization problem with a performance bound-defined constraint.

Machine Learning Model for Predicting Risk of In-Hospital Mortality after Surgery in Congenital Heart Disease Patients.

Background: A machine learning model was developed to estimate the in-hospital mortality risk after congenital heart disease (CHD) surgery in pediatric patient.

Methods: Patients with CHD who underwent surgery were included in the study. A Extreme Gradient Boosting (XGBoost) model was constructed based onsurgical risk stratification and preoperative variables to predict the risk of in-hospital mortality.

Multi-strategy improved salp swarm algorithm and its application in reliability optimization.

To improve the convergence speed and solution precision of the standard Salp Swarm Algorithm (SSA), a hybrid Salp Swarm Algorithm based on Dimension-by-dimension Centroid Opposition-based learning strategy, Random factor and Particle Swarm Optimization's social learning strategy (DCORSSA-PSO) is proposed. Firstly, a dimension-by-dimension centroid opposition-based learning strategy is added in the food source update stage of SSA to increase the population diversity and reduce the inter-dimensional interference. Secondly, in the followers' position update equation of SSA, constant 1 is replaced by a random number between 0 and 1 to increase the randomness of the search and the ability to jump out of local optima.

Surgical management of long-segment congenital tracheal stenosis with tracheobronchial malacia.

Objectives: Slide tracheoplasty has become the mainstream treatment for long-segment congenital tracheal stenosis (LSCTS). However, technical improvements are still needed to improve the clinical outcomes of patients exhibiting LSCTS with tracheobronchial malacia.

Methods: LSCTS patients who underwent tracheoplasty from January 2010 to December 2020 were reviewed.

Surgical management strategy of slide tracheoplasty for infants with congenital tracheal stenosis.

Objective: The study objective was to evaluate the outcomes of slide tracheoplasty in infancy and identify predictors of adverse outcomes.

Methods: We retrospectively reviewed the clinical data of infants aged less than 1 year with congenital tracheal stenosis who underwent slide tracheoplasty at a single center from April 2010 to September 2020.

Results: Of 120 infants, 71.

Retrospective analysis of the effect of current clinical medications and clinicopathological factors on viral shedding in COVID-19 patients.

The aim of the present study was to identify the risk factors associated with prolonged shedding in patients with coronavirus disease 2019 (COVID-19), and to evaluate the effects of current clinical and clinicopathological factors on viral shedding in patients. A total of 186 COVID-19 inpatients were enrolled in this multicentre retrospective analysis. Detailed clinical data of each patient were collected, and the factors that affected the duration of viral shedding were retrospectively analysed.

Morphologic Analysis of Congenital Heart Disease With Anomalous Tracheobronchial Arborization.

Background: This study investigated the morphologic characteristics of congenital heart disease (CHD) combined with anomalous tracheobronchial arborization (ATBA) to provide new considerations for surgically treating congenital tracheal stenosis.

Methods: A retrospective review of surgical experience with ATBA was conducted of 147 patients. The proportion of patients with ATBA combined with tracheal stenosis was determined.

Risk factors for low cardiac output syndrome in children with congenital heart disease undergoing cardiac surgery: a retrospective cohort study.

Background: Low cardiac output syndrome (LCOS) is an important complication of cardiac surgery. It is associated with increased morbidity and mortality. The incidence of LCOS after surgery is high in patients with congenital heart disease (CHD).

Tunable multiple-passband microwave photonic filter based on external optical injected Fabry-Pérot laser.

This paper proposes a tunable multiple-passband microwave photonic filter (MPF) that is incorporated with an injection-locked Fabry-Pérot (FP) laser. In the proposed MPF, multiple passbands can be easily generated based on the frequency-selection effects of the laser structure in the case of multiple light waves injection. The novelty here is that the obtained multiple-passband MPF can achieve either a dual-passband or a single-passband by using merely one experimental scheme.