Publications by authors named "Xintong Du"

Flow cessation leads to severe degradation of river corridor landscape structure, habitat quality, and ecological functions. This study focuses on the representative river with ceased flow in northern China, the Yongding River plain section. Utilizing long-term, high-resolution satellite remote sensing imagery and the InVEST model, we analyzed the spatiotemporal evolution of landscape structure and habitat quality (HQ) before and after river corridor flow cessation over the past 50 years.

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In a ship rocking environment, muscle activity in different sitting postures may impact passenger balance and stability, thereby aggravating or alleviating symptoms of motion sickness. This study aims to explore the relationship between motion sickness induced by ship rolling and muscle activity in various sitting postures, with the goal of informing the optimization of ship seat designs to enhance passenger comfort. The research focuses on the angle of backrest inclination and head-neck position as key variables.

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Background: Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers worldwide. POC1 centriolar protein A () is a gene encoding a protein that plays a key role in the centrosome, and is one of the two isoforms of POC1. To date, the expression of in HCC and its potential as a biomarker and tumor therapeutic target have not been examined.

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Article Synopsis
  • Broccoli contains sulforaphane (SFN), which has beneficial properties such as anti-inflammatory, antioxidant, and anti-cancer effects, and researchers developed SFN derivatives for potential antidepressant benefits.
  • The study identified SLL-III-9 and SLL-III-120 as effective SFN derivatives that improved depression-like behaviors in mice and influenced gut bacteria composition, suggesting a link to the microbiota-gut-brain axis.
  • SFN and its derivatives were shown to enhance protective proteins, increase levels of neurotransmitters and brain-derived neurotrophic factor, and reduce inflammatory factors, indicating their potential as safe antidepressant agents.
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The application of chemotherapy drugs in tumor treatment has a long history, but the lack of selectivity of drugs often leads to serious side effects during chemotherapy. The natural anti-tumor ingredients derived from Chinese herbal medicine are attracting increased attention due to their diverse anti-tumor effects, abundant resources, and minimal side effects. An effective anti-tumor strategy may lie in the combination of these naturally derived anti-tumor ingredients with conventional chemotherapy drugs.

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Against the backdrop of global warming, rapid urbanization has caused the aggregation of urban building spaces and the heat island effect is becoming increasingly serious, hindering sustainable urban development. In order to investigate the potential and methods of green roofs in different types of neighborhoods to mitigate the urban heat island effect, this study used multivariate data for surface temperature inversion and local climate zone (LCZ), and the potential of green roofs to reduce the heat island effect was evaluated by combining LCZ zoning and ENVI-met prediction model. Finally, a multi-scenario analysis with economic factors was conducted to derive the optimal implementation path for green roofs.

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Expression of β2-microglobulin (β2M) is involved in fibrosis progression in kidney, liver, and heart. In this case-controlled retrospective study, we investigated the role of β2M in the development of pulmonary fibrosis in patients with chronic obstructive pulmonary disease (COPD). Analysis of 450 COPD patients revealed that patients with decreased pulmonary diffusing capacity (DLCO) had increased β2M serum levels.

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Diabetes mellitus can reinforce the small airway dysfunction of chronic obstructive pulmonary disease (COPD) patients. The epithelial-mesenchymal transition (EMT) that is associated with small airway remodeling is activated in the airway epithelial cells (AECs) of both COPD patients and diabetic patients. Transforming growth factor β (TGF-β) can induce EMT via the TGF-β/Smad pathway.

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