Guest-Facilitated Heteroleptic Assembly of Helical Anionocages Enables Reversible Chirality Modulation.

We report a novel strategy for reversible modulation of the supramolecular chirality based on guest-facilitated heteroleptic assembly of helical anionocages. Two triple-stranded helical anionocages including a chiral cage 1 (A L ) and a crown ether functionalized achiral cage 2 (A L ) were synthesized by anion coordination of bis-monourea-based ligands and PhPO . Both cages exhibited favorable binding with tetraethylammonium TEA and cobaltocenium Cob (endo-guest, bound in the cavity).