EPS-8 regulates human malignant melanoma development by activating the Hedgehog pathway via degradation of Ptch1.

Background: The epidermal growth factor receptor pathway substrate 8 (EPS-8) is a tumor-associated antigen that is frequently overexpressed in various types of human solid tumors and is associated with aggressiveness and poor prognosis. The role of EPS-8 in cutaneous malignant melanoma and its potential mechanism remains unknown.

Methods: EPS-8 expression, mutation immune infiltration, and the tumor microenvironment in melanoma were analyzed using various databases.

PAI-1 siRNA-loaded biomimetic nanoparticles for ameliorating diminished ovarian reserve and inhibiting ovarian fibrosis.

With specific and inherent mRNA cleaving activity, small interfering RNA against pro-fibrosis factor (PAI-1 siRNA, siPAI-1) has demonstrated the fucntion for preventing diminished ovarian reserve (DOR). Moreover, safe nanomaterials have provided ideal tools for delivering siRNA to the targeted cells to obtain high therapeutic efficacy. In order to improve the preventing capability of siPAI-1 for DOR, we synthesized one kind of biomimetic Poly (lactic-co-glycolic acid) copolymer (PLGA)-based nanoparticles (siPAI-1@PLGA@M-FSHL, abbreviated as SPMF).

Design, Synthesis and Evaluation of a Novel Teoptinib Derivative as an Effective Anti-hepatocellular Carcinoma Agent.

Background & Purpose: Hepatocellular Carcinoma (HCC) is a type of liver cancer known for its poor prognosis and high mortality. Teoptinib is a highly selective MET inhibitor that has been used in the treatment of liver cancer. Although good progress has been made in clinical treatment, further improvement is still needed.

MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(Y)-regulated kinase 1A.

Background: Radiotherapy stands as a promising therapeutic modality for colorectal cancer (CRC); yet, the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC remission.

Aim: To elucidate the role played by microRNA-298 (miR-298) in CRC radio-resistance.

Methods: To establish a radio-resistant CRC cell line, HT-29 cells underwent exposure to 5 gray ionizing radiation that was followed by a 7-d recovery period.

() Manning & Holthuis, 1981, a new natural host for infection.

Recent reports have shown that wild crabs may be important hosts involved in the transmission and spread of the parasitic in cultured marine crustaceans. Therefore, monitoring the prevalence of infections in wild crabs is necessary to develop effective strategies for the prevention and control of disease. Here we report a wild crab species, () Manning & Holthuis, 1981, as a new natural host for sp.

Comprehensive analysis of P2Y family genes expression, immune characteristics, and prognosis in pan-cancer.

Background: P2Y receptors are a family of G protein-coupled receptor genes that have an important function in cancer development and metastasis. However, systematic studies have not been conducted on human tumors. This study attempted to explore the role of P2Y family genes (P2Ys) in pan-cancer.

Prediction and Analysis of Housing Price Based on the Generalized Linear Regression Model.

In order to improve the reliability of housing price prediction and analysis, this article combines the generalized linear regression model to build a real estate price prediction model and analyzes the basic knowledge of data mining. On the basis of this prior knowledge, this article investigates the cluster analysis algorithm and selects the generalized linear regression model as the research focus based on its definition and the characteristics of stock data. Moreover, this article analyzes the estimation methods of the generalized linear regression model and the nonparametric regression model, and then gives the estimation method of a partial linear model.

Hematodinium perezi naturally infects Asian brush-clawed crab (Hemigrapsus takanoi).

The parasitic dinoflagellates of the genus Hematodinium have been considered one of the most important emerging pathogens for a broad range of marine crustaceans around the world. In China, frequent outbreaks of Hematodinium infections have caused serious economic losses for local farmers since 2004. Wild crabs were recently indicated to play a vital role in the transmission and spreading of the Hematodinium disease in polyculture pond systems.

Characterization of a novel shrimp pathogen, Vibrio brasiliensis, isolated from Pacific white shrimp, Penaeus vannamei.

A novel pathogenic strain Vibrio 20190611023 was isolated from the hepatopancreas of moribund cultured Penaeus vannamei suffering from black gill disease. This strain was identified as V. brasiliensis based on the phylogenetic analyses of 16S rDNA gene and five other housekeeping genes (i.

A water-stable MOF-AgClO-abtz as fluorescent sensor for detection of folic acid based on inner filter effect.

Folic acid (FA, Vitamin B9), as a water-soluble chemical compound of the vitamin B groups, plays an important role to human health. Thus, it is of great significance to develop sensitive assays for detection of FA. Herein, we prepared a water-stable metal-organic frameworks {[Ag(μ-abtz)(μ-abtz)(ClO)]⋅(ClO)} (MOF-AgClO-abtz; abtz = 1-(4-aminobenzyl)-1, 2, 4,-triazole) material, which exhibited a high fluorescent quantum yield of 78.

Assessment of the iodine nutritional status among Chinese school-aged children.

Objective: The remarkable success of iodine deficiency disorders (IDD) elimination in China has been achieved through a mandatory universal salt iodization (USI) program. The study aims to estimate the relationship between urinary iodine concentration (UIC) and iodine content in edible salt to assess the current iodine nutritional status of school aged children.

Methods: A total of 5565 students from 26 of 39 districts/counties in Chongqing participated in the study, UIC and iodine content in table salt were measured.

Zinc toxicity alters the photosynthetic response of red alga Pyropia yezoensis to ocean acidification.

The globally changing environmental climate, ocean acidification, and heavy metal pollution are of increasing concern. However, studies investigating the combined effects of ocean acidification and zinc (Zn) exposure on macroalgae are very scarce. In this study, the photosynthetic performance of the red alga Pyropia yezoensis was examined under three different concentrations of Zn (control, 25 (medium), and 100 (high) μg L) and pCO (400 (ambient) and 1000 (high) μatm).

Effects of increased CO and temperature on the physiological characteristics of the golden tide blooming macroalgae Sargassum horneri in the Yellow Sea, China.

The golden tide, caused by the brown algae Sargassum horneri, exerts severe influences on the Pyropia aquaculture of Jiangsu coast, China. To study the outbreak of the golden tide in response to increasing greenhouse gas emissions, S. horneri was cultured under four conditions: ambient condition (10 °C, 400 μatm), elevated temperature condition (14 °C, 400 μatm), elevated CO level (10 °C, 1000 μatm), and potential greenhouse condition (14 °C, 1000 μatm).

A two-stage model with nitrogen and silicon limitation enhances lipid productivity and biodiesel features of the marine bloom-forming diatom Skeletonema costatum.

To enhance biodiesel production and quality from a bloom-forming diatom Skeletonema costatum, a two-stage model, in which cells were cultured in nutrient replete conditions first and then transferred to nutrient limitation conditions, was explored. Compared to one-stage model, nutrient limitation in the second stage significantly increased lipid content in spite of decreasing growth; consequently, Si-limitation and N-Si-limitation respectively increased lipid productivity by 37.6% and 76.

Designing an "Off-On" Fluorescence Sensor Based on Cluster-Based Ca-Metal-Organic Frameworks for Detection of l-Cysteine in Biological Fluids.

Recently, luminescent metal-organic framework (MOF) materials have attracted considerable attention in fluorescence sensing. In this essay, we prepared a new cluster-based Ca-MOFs {[Ca(μ-HL)(DMF)]·DMF} () with good water dispersibility, excellent photoluminescence properties (FL quantum yield of 20.37%) and great fluorescence stability.

Future CO-induced seawater acidification mediates the physiological performance of a green alga in different photoperiods.

Photoperiods have an important impact on macroalgae living in the intertidal zone. Ocean acidification also influences the physiology of macroalgae. However, little is known about the interaction between ocean acidification and photoperiod on macroalgae.

Different Photosynthetic Responses of Pyropia yezoensis to Ultraviolet Radiation Under Changing Temperature and Photosynthetic Active Radiation Regimes.

Macroalgae play a crucial role in coastal marine ecosystems, but they are also subject to multiple challenges due to tidal and seasonal alterations. In this work, we investigated the photosynthetic response of Pyropia yezoensis to ultraviolet radiation (PAR: 400-700 nm; PAB: 280-700 nm) under changing temperatures (5, 10 and 15°C) and light intensities (200, 500 and 800 μmol photons m  s ). Under low light intensity (200 μmol photons m  s ), P.

Nitrogen availability modulates the effects of ocean acidification on biomass yield and food quality of a marine crop Pyropia yezoensis.

Pyropia yezoensis is an important marine crop in the world. We cultured it under two levels of partial pressure of carbon dioxide (pCO) (408 (LC), 998 (HC) μatm) and nitrate (30 (LN) and 500 (HN) μmol L) to investigate the effect of ocean acidification on its growth and food quality under changing nitrogen supply. HC decreased growth rate of P.

Physiological acclimation of the green tidal alga Ulva prolifera to a fast-changing environment.

To aid early warning and prevent the outbreak of green tides in the Yellow Sea, both the growth and photosynthetic performance of Ulva prolifera were studied after culture in different temperatures (18, 22, and 26 °C) and light intensities (44, 160, and 280 μmol m·s). Furthermore, their instantaneous net photosynthetic performance (INPP) was studied to determine the resulting environmental acclimation. The relative growth rates of U.

Accurate identification of layer number for few-layer WS and WSe via spectroscopic study.

Transition metal dichalcogenides (TMDs) with a typical layered structure are highly sensitive to their layer number in optical and electronic properties. Seeking a simple and effective method for layer number identification is very important to low-dimensional TMD samples. Herein, a rapid and accurate layer number identification of few-layer WS and WSe is proposed via locking their photoluminescence (PL) peak-positions.

Correction to: Relative abundance of β-thalassemia-related mutations in southern China correlates with geographical coordinates.

Figure 1c. is with numeric error. The error can not result in any change of discussion and conclusion.

Controlled Gas Molecules Doping of Monolayer MoS via Atomic-Layer-Deposited AlO Films.

MoS as atomically thin semiconductor is highly sensitive to ambient atmosphere (e.g., oxygen, moisture, etc.

Transcriptome-Wide Identification and Prediction of miRNAs and Their Targets in Paris polyphylla var. yunnanensis by High-Throughput Sequencing Analysis.

Long dormancy period of seeds limits the large-scale artificial cultivation of the scarce var. , an important traditional Chinese medicine. Characterizing miRNAs and their targets is crucial to understanding the role of miRNAs during seed dormancy in this species.