Introduction: Clinical practice is a cornerstone of undergraduate training in Chinese medical education, ensuring the development of essential skills for future professionals. While flipped classrooms have gained popularity for their potential to enhance learning outcomes, the effectiveness of this approach in clinical settings remains underexplored. This study aims to address this research gap by consolidating evidence on the impact of flipped classrooms through a comprehensive meta-analysis.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Power generation and architectural beauty are equally important for designing efficient and esthetically appealing bifacial perovskite solar cells (PSCs). In this work, efficient and multicolored p-i-n-structured PSCs are achieved by taking advantage of a dielectric/metal/dielectric (DMD)-type (MoO/Ni/Ag/MoO) transparent counter electrode. The MoO/Ni underlayer effectively promotes the formation of a continuous and conductive ultrathin Ag transparent film, especially the 1 nm Ni seed layer adjusts the interface energy level between perovskite/MoO and Ag, resulting in Ohmic contact of the electrode to promote charge extraction and collection.
View Article and Find Full Text PDFBiochem Biophys Res Commun
January 2025
Angiogenesis significantly drives tumor progression, and the functions of vascular endothelial cells are influenced by various factors. Tumor cells are characterized by abnormal sialylation, and their dynamic balance depends on sialyltransferases and sialidases. NEU3 is a plasma membrane-associated sialidase, vital for the regulation of cell surface sialylation.
View Article and Find Full Text PDFThis study explores the potential medicinal properties of Bletilla striata fibrous roots by comparing their active ingredient contents and antioxidant activity with those in tubers. The study further examines the effects of growth age and origin on the distribution characteristics of medicinal properties in fibrous roots and identifies biomarkers that distinguish these characteristics. The Δ E value of fibrous roots significantly increases with age and is significantly influenced by origin; both the age and origin also significantly affect militarine content and antioxidant activity; a positive correlation exists between appearance quality, active ingredients, and antioxidant activity.
View Article and Find Full Text PDFPurpose: This study aimed to evaluate fetal left ventricular function (LVF) in pregnant women with obstetric antiphospholipid syndrome (OAPS) by Doppler ultrasound and developed a clinical nomogram to predict adverse perinatal outcomes.
Methods: In this prospective observational study, 105 pregnant women were enrolled and divided into the OAPS cohort (n = 60) and the control cohort (n = 45). Fetal cardiac function parameters were collected and compared between two cohorts.
The endometrium is an important part of women's bodies for menstruation and pregnancy. Various proteins are widely expressed on the surface of endometrial cells, and glycosylation is an important post-translational modification of proteins. Glycosylation modification is closely related not only to endometrial receptivity but also to common diseases related to endometrial receptivity.
View Article and Find Full Text PDFHigh-grade serous ovarian cancer (HGSOC) remains the most lethal female cancer by far. Herein, clinical HGSOC samples had higher N-methyladenosine (mA) modification than normal ovarian tissue, and its dysregulation had been reported to drive aberrant transcription and translation programs. However, Kringle-containing transmembrane protein 2 (KREMEN2) and its mA modification have not been fully elucidated in HGSOC.
View Article and Find Full Text PDFThe effect of obesity on pregnancy outcomes of patients with polycystic ovary syndrome (PCOS) undergoing assisted reproductive technology (ART) remains unclear. As such, a meta-analysis of recent studies was conducted to probe the effect of being overweight or obese on ART pregnancy outcomes in patients with PCOS. PubMed, Embase, MEDLINE, Scopus and Web of Science were searched from inception to 22 July 2023 without language restrictions.
View Article and Find Full Text PDFBackground: Extravillous trophoblasts (EVTs) are essential cells during the formation of the placenta, with the major function of invading the maternal decidua, anchoring the developing placenta to the uterus, remodeling uterine arteries, and regulating immune responses to prevent rejection. During early pregnancy, the decidua undergoes a hypoxic and acidic microenvironment, which has been shown to participate in tumor cell migration, invasion, growth, and angiogenesis. Nevertheless, the mechanisms by which EVTs sense and respond to the acidic microenvironment, thereby executing their functions, remain poorly understood.
View Article and Find Full Text PDFInfertility is a challenging health problem that affects 8-15% of couples worldwide. Establishing pregnancy requires successful embryo implantation, but about 85% of unsuccessful pregnancies are due to embryo implantation failure or loss soon after. Factors crucial for successful implantation include invasive blastocysts, receptive endometrium, invasion of trophoblast cells, and regulation of immune tolerance at the maternal-fetal interface.
View Article and Find Full Text PDFArch Public Health
August 2023
Objective: The coronavirus disease 2019 was a global public health emergency in later years (from 2020 to early 2022), and androgens have been associated with infection and prognostic outcomes. However, the relationship between low serum testosterone levels and prognostic outcomes remains inconclusive. This systematic review aimed to investigate the relationship between serum testosterone levels and prognostic outcomes in patients with COVID-19.
View Article and Find Full Text PDFBackground: Universal COVID-19 vaccination programs are now recommended in several countries and represent the most effective preventive measure against COVID-19. However, some reports suggest that vaccination may cause infertility or have adverse effects on pregnancy. Conflicting reports have led to vaccine hesitancy in women planning pregnancy.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
February 2023
The Yellow River basin (YRB) plays an important role in China's economic and social growth. Based on different dimensions, we adopted the radial basis function (RBF) neural network model and the obstacle degree model to examine the water resource carrying capacity (WRCC) of the YRB. From 2005 to 2020, the WRCC of the entire YRB, as well as the upstream and midstream regions, improved, but the WRCC of the downstream region remained poor, revealing spatial differences.
View Article and Find Full Text PDFEcological compensation in the Yellow River Basin aims to improve its ecological and environmental management capacity. Based on data on land-use changes in the Yellow River Basin from 2010 to 2020, this study used the equivalent factor method to assess the value of ecosystem services in the basin. This was measured at three spatial scales in the upper, middle, and lower reaches, encompassing; nine provinces and 72 cities.
View Article and Find Full Text PDFInt J Environ Res Public Health
December 2019
As the modern economy develops rapidly, environmental pollution and human health have also been threatened. In recent years, relevant research has focused on subjects such as energy and economic, environmental pollution and health issues. Yet this has not considered the use of water resources and the impact of wastewater pollutant emissions on the economy and health.
View Article and Find Full Text PDFGibberellins (GAs) participate in controlling various aspects of basic plant growth responses. With the exception of bryophytes, GA signalling in land plants, such as lycophytes, ferns and angiosperms, is mediated via GIBBERELLIN-INSENSITIVE DWARF1 (GID1) and DELLA proteins. To explore whether this GID1-DELLA mechanism is present in pines, we cloned an orthologue (PtGID1) of Arabidopsis AtGID1a and two putative DELLA proteins (PtDPL; PtRGA) from Pinus tabuliformis, a widespread indigenous conifer species in China, and studied their recombinant proteins.
View Article and Find Full Text PDFThe development of reproductive structures in gymnosperms is still poorly studied because of a lack of genomic information and useful genetic tools. The hermaphroditic reproductive structure derived from unisexual gymnosperms is an even less studied aspect of seed plant evolution. To extend our understanding of the molecular mechanism of hermaphroditism and the determination of sexual identity of conifer reproductive structures in general, unisexual and bisexual cones from Pinus tabuliformis were profiled for gene expression using 60K microarrays.
View Article and Find Full Text PDFIntroduction: This prospective study was to investigate the successful rate of intraoperative motor evoked potentials (MEP) monitoring for children (<12 years old) with congenital scoliosis.
Materials And Methods: A consecutive series of 27 young children (7 girls and 20 boys; from 1 to 11 years old) between September 2007 and November 2009, were enrolled to this study. 12 patients received general anesthesia based on TIVA, induced with propofol 2-4 mg/kg and fentanyl 3-5 µg/kg followed by a continuous infusion of propofol (20-150 µg/kg/min, at mean of 71.