Huang-Lian-Jie-Du decoction alleviates cognitive impairment in high-fat diet-induced obese mice via Trem2/Dap12/Syk pathway.

Background: Cognitive impairment induced by a high-fat diet (HFD) is common, but its mechanism is largely unknown. Huang-Lian-Jie-Du (HLJD) decoction is a classical and powerful prescription in China. It consists of four medicinal plants and is widely used in traditional Chinese medicines (TCM).

Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II.

Sialylation catalysed by sialyltransferase 7A (SIAT7A) plays a role in the development of cardiac hypertrophy. However, the regulatory mechanisms upstream of SIAT7A in this context remain poorly elucidated. Previous study demonstrated that KLF4 activates the SIAT7A gene in ischemic myocardium by binding to its promoter region.

Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway-mediated neuroinflammation in db/db mice.

Diabetes mellitus (DM), an important public health problem, aggravates the global economic burden. Diabetic encephalopathy (DE) is a serious complication of DM in the central nervous system. Metformin has been proven to improve DE.

High-efficiency preparation of starch nanocrystals with small size and high crystallinity by ethanol-acid penetration and dry-heating pretreatment.

Ethanol-acid penetration and drying-heating treatment was developed to shorten the preparation time and improve the quality of starch nanocrystals (SNCs). After treatment by optimized parameters, including 40 % ethanol solution, 10.6 mM chloric acid, and heating time of 1.

Pb-Modified Ultrathin RuCu Nanoflowers for Active, Stable, and CO-resistant Alkaline Electrocatalytic Hydrogen Oxidation.

CO poisoning of Pt group metal (PGM) catalysts is a chronic problem for hydrogen oxidation reaction (HOR), the anodic reaction of hydroxide exchange membrane fuel cell (HEMFC) for converting H to electric energy in sustainable manner. We demonstrate here an ultrathin Ru-based nanoflower modified with Pb (PbRuCu NF) as an active, stable, and CO-resistant catalyst for alkaline HOR. Mechanism studies show that the presence of Pb can weaken the adsorption of *H, strengthen *OH adsorption to facilitate CO oxidation, as a result of significantly enhanced HOR activity and improved CO tolerance.

IFKD: Implicit field knowledge distillation for single view reconstruction.

In 3D reconstruction tasks, camera parameter matrix estimation is usually used to present the single view of an object, which is not necessary when mapping the 3D point to 2D image. The single view reconstruction task should care more about the quality of reconstruction instead of the alignment. So in this paper, we propose an implicit field knowledge distillation model (IFKD) to reconstruct 3D objects from the single view.

Sub-Monolayer SbO on PtPb/Pt Nanoplate Boosts Direct Formic Acid Oxidation Catalysis.

To promote the commercialization of direct formic acid fuel cell (DFAFC), it is vital to explore new types of direct formic acid oxidation (FAOR) catalysts with high activity and direct pathway. Here, we report the synthesis of intermetallic platinum-lead/platinum nanoplates inlaid with sub-monolayer antimony oxide surface (PtPb/Pt@sub-SbO NPs) for efficient catalytic applications in FAOR. Impressively, they can achieve the remarkable FAOR specific and mass activities of 28.

Platinum-Lead-Bismuth/Platinum-Bismuth Core/Shell Nanoplate Achieves Complete Dehydrogenation Pathway for Direct Formic Acid Oxidation Catalysis.

Designing platinum (Pt)-based formic acid oxidation reaction (FAOR) catalysts with high performance and high selectivity of direct dehydrogenation pathway for direct formic acid fuel cell (DFAFC) is desirable yet challenging. Herein, we report a new class of surface-uneven PtPbBi/PtBi core/shell nanoplates (PtPbBi/PtBi NPs) as the highly active and selective FAOR catalysts, even in the complicated membrane electrode assembly (MEA) medium. They can achieve unprecedented specific and mass activities of 25.

Research on the Duality of China's Marine Fishery Carbon Emissions and Its Coordination with Economic Development.

Through the Tapio model, this paper measures the "decoupling and coupling" relationship between carbon emissions, carbon sinks, and economic growth of marine fisheries in nine coastal provinces of China in 2009-2019, objectively evaluates the economic benefits of carbon emissions and low-carbon development potential, and then discusses the economic development models of marine fisheries in detail. The results showed that the total carbon sink and carbon emission of China's marine fisheries are increasing. Guangdong is dominated by "double low" economic benefits and low-carbon potential, and "double high" provinces have better resource endowment conditions; China's marine fishery economic development is still dominated by conventional types.

Enhancing Ristomycin A Production by Overexpression of ParB-Like StrR Family Regulators Controlling the Biosynthesis Genes.

sp. strain TNS106 harbors a ristomycin-biosynthetic gene cluster () in its genome and produces ristomycin A. Deletion of the sole cluster-situated StrR family regulatory gene, , abolished ristomycin A production and the transcription of the genes to .

Prevalence of neutralizing antibodies against liver-tropic adeno-associated virus serotype vectors in 100 healthy Chinese and its potential relation to body constitutions.

Recombinant adeno-associated virus (rAAV) serotype 2, 3 and 8 vectors are the most promising liver-tropic AAV serotype vectors. Liver diseases are significant problems in China. However, to date, few studies on AAV neutralizing antibodies (Nabs) were working with the Chinese population or with the rAAV3 vectors.