Insights of Surface-Enhanced Raman Spectroscopy Detection by Guiding Molecules into Nanostructures to Activate Hot Spots.

A misunderstanding of how target molecules enter hot spot nanostructures has significantly hindered the advancement of surface-enhanced Raman spectroscopy (SERS) detection methods in recent years. The challenge lies in finding convenient ways to transport target molecules to various nanostructures. In this work, we discovered that filling the gaps in empty nanostructures with water is often difficult, as metal surfaces are not well wetted.

Effects of Polysaccharide Supplementation on Lactic Acid Bacteria-Fermented Soy Protein Gel: Structural Characteristics, Allergenicity, and Epitope Analysis.

Background: Soy allergy is an important nutritional and health issue that needs to be addressed. Lactic acid bacteria (LAB) fermentation is an effective approach to reduce soy protein allergy. Polysaccharides are commonly used in LAB-fermented products to enhance their textural properties.

Diagnostic and Therapeutic Approach to Rare Tongue Lipoma.

Lipomas are benign soft tissue tumors composed of mature adipocytes, commonly found in subcutaneous tissues. Despite their prevalence in various body regions, they are relatively rare in the oral and maxillofacial regions. This study retrospectively analyzed the clinical and imaging characteristics, as well as the treatment outcomes of 57 patients diagnosed with lipoma.

A Rare Case of Submandibular Neurilemmoma Inducing Submandibular Gland Sialolithiasis.

Most sialolithiasis occurs in the submandibular glands, which are highly related to the anatomy and secretory function of the submandibular glands. The authors report an 18-year-old patient with multiple submandibular gland duct stones combined with submandibular neurilemmoma. The course of diagnosis and treatment is highlighted, and the causes of the formation of multiple stones in this patient are analyzed.

Design of novel dual-emitting ratiometric fluorescence system based on FMT-CDs and MnO NS for sensitive isoniazid detection in urine sample.

In this work, a simple and sensitive ratiometric fluorescence probe to detect isoniazid (INH) was developed on the basis of carbon dots and MnO nanosheets (MnO NS). Nitrogen-doped carbon dots (FMT-CDs) were synthesized by microwave method using formononetin (FMT) in ammonia water. The oxidase-like activity of MnO NS was utilized to oxidize non-fluorescent o-phenylenediamine (OPD) to 2, 3-diaminophenazine (DAP) with orange fluorescence.

Oxidative and Endoplasmic Reticulum Stress Mediate Testicular Injury in a Rat Model of Varicocele.

Evidence of endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) have been increasingly reported in varicocele (VCL)-affected testes. However, the mechanisms by which oxidative stress (OS) and ER stress contribute to male infertility in VCL remain unclear. In this study, male Sprague-Dawley rats were divided into a control group, which underwent sham surgery, and a VCL group, in which VCL was surgically induced.

Microbiome of diseased and healthy implants-a comprehensive microbial data analysis.

Objective: The purpose of this systematic bioinformatics analysis was to describe the compositions and differences in submucosal microbial profiles of peri-implants' diseases and healthy implant.

Material And Methods: PubMed, Embase, ETH Z, Scopus, CNKI, and Wanfang databases were searched to screen relevant literature on the analysis of peri-implant microflora based on the sequencing analysis technique of 16S ribosomal RNA (16S rRNA) gene. High-throughput sequencing of the 16S rRNA gene of microorganisms from healthy implants, peri-implant mucositis, and peri-implantitis was downloaded from the screened articles.

Design of Ratio-Fluorescence Nanohybrid Based on Radix Green-Synthesized CDs and GSH-AuNCs for Sensitive Detection of Cefodizime Sodium in Urine Sample.

A dual-emission ratio-fluorescent sensing nanohybrid based on Radix green-synthesized carbon quantum dots (CDs) and glutathione-functionalized gold nanoclusters (GSH-AuNCs) had been developed for the determination of cefodizime sodium (CDZM). The designed fluorescence nanohybrid had two significant fluorescence emission peaks at 458 nm and 569 nm when excited at 360 nm, which was attributed to the CDs and GSH-AuNCs. With the addition of CDZM, the fluorescence at 458 nm was slightly weakened while the fluorescence at 569 nm was enhanced obviously.

Correction: Fluorescence detection of three types of pollutants based on fluorescence resonance energy transfer and its comparison with colorimetric detection.

[This corrects the article DOI: 10.1039/D3RA02647G.].

The Brown Sugar Mediated Carbon Quantum Dots as a Novel Fluorescence Sensor for Sensitive Detection of Gentamicin and Its Application in Foods.

In this work, a novel fluorescence sensing strategy was proposed for the detection of gentamicin based on fluorescent carbon quantum dots (CQDs) and gold nanoparticles (AuNPs). Herein, the CQDs were green-synthesized for the first time via a one-step hydrothermal method utilizing brown sugar as the precursor. In the presence of citrate-stabilized AuNPs, the fluorescence of CQDs was quenched efficiently.

Construction of hypoallergenic microgel by soy major allergen β-conglycinin through enzymatic hydrolysis and lactic acid bacteria fermentation.

Soy allergenicity is a public concern, and the combination of multiple processing methods may be a promising strategy for reducing soy allergenicity. In this study, a novel two-step enzymatic hydrolysis followed by lactic acid bacteria fermentation was proposed for the construction of hypoallergenic soybean protein microgel. β-Conglycinin was used as the main soy allergen.

High-detection-efficiency stereo microscope system based on a mobile phone.

Most stereoscopic microscopes used for industrial component detection are large and have low detection efficiencies. The use of mobile phones as imaging systems (rather than conventional sensors) in industrial fields would make industrial testing more convenient. In this study, an external stereo microscope for mobile phones is designed.

Aggregation-induced emission enhancement of gold nanoclusters triggered by sodium heparin and its application in the detection of sodium heparin and alkaline amino acids.

This work first reported that sodium heparin could cause the aggregation-induced emission enhancement (AIEE) effect of GSH-AuNCs (Glutathione functionalized gold nanoclusters). While it was interestingly found that the addition of alkaline amino acids would greatly weaken this effect. Thus, fluorescent system was designed for the quantitative detection of sodium heparin and alkaline amino acids.

Preliminary Test for 3D Surface Strain Measurement in the Tower and Foundation of Offshore Wind Turbines Using DOFS.

Subjected to the relentless impacts of typhoons and rough seas, offshore wind turbines' structures, particularly the tower, foundation, and blade, are at constant risk of damage. Full-field strain monitoring helps to discover potential structural defects, thereby reducing disasters caused by overall structural failure. This study introduces a novel method for assessing strain and temperature fields on these kinds of 3D surfaces of cylindrical structures.

Redefining work-life balance: women at the helm of the post-pandemic coworking revolution.

The post-pandemic era has transformed work-life boundaries, driven by factors such as working hours, an increased number of working women and single parents, the implementation of various ICTs, and the rise of flexible work arrangements. This study examines the role of female workers and entrepreneurs in establishing and managing coworking spaces (CSs) designed to improve work-life balance through flexible scheduling and location options. The challenges faced by female entrepreneurs in promoting an inclusive society and economic system are also explored, as well as the benefits experienced by independent workers and teleworkers in terms of networking, social interaction, knowledge exchange, and community building.

Huperzine A injection ameliorates motor and cognitive abnormalities via regulating multiple pathways in a murine model of Parkinson's disease.

As a common progressive neurodegenerative disorder, the satisfied therapies for Parkinson's disease (PD) are still unavailable. As a natural acetylcholinesterase inhibitor, the neuroprotective characteristic of Huperzine A (HupA) was supported by previous studies. However, questions remain on whether HupA injection (HAI, a main preparation of HupA) intervention conduces to PD treatment and if so, the potential molecular mechanisms.

Fluorescence detection of three types of pollutants based on fluorescence resonance energy transfer and its comparison with colorimetric detection.

This study aimed at three representative pollutants, benzidine, cyromazine, and streptomycin, which were commonly used and posed a great threat to both environment and human health, mainly to explore a fast, simple, sensitive, visible naked-eye detection method. Colorimetric detection by gold nanoparticles (AuNPs) was first attempted. The cross-linking reaction occurred owing to the strong forces between the targets and AuNPs, leading to aggregation and color change.

Intravitreal injection of Huperzine A promotes retinal ganglion cells survival and axonal regeneration after optic nerve crush.

Traumatic optic neuropathy (TON) is a condition that causes massive loss of retinal ganglion cells (RGCs) and their axonal fibers, leading to visual insufficiency. Several intrinsic and external factors can limit the regenerative ability of RGC after TON, subsequently resulting in RGC death. Hence, it is important to investigate a potential drug that can protect RGC after TON and enhance its regenerative capacity.

Dual-Photosensitizer Nanoplatform Based on Near-Infrared Excitation Orthogonal Emission Nanomaterials for Enhanced Photodynamic Therapy of Tumors.

Photodynamic therapy (PDT) is considered as a promising therapeutic approach for clinical cancer treatment. However, the hypoxia of the tumor microenvironment leads to the low effect of single PDT. Here, a dual-photosensitizer nanoplatform based on near-infrared excitation orthogonal emission nanomaterials is constructed by introducing two kinds of photosensitizers into the nanosystem.

Syringe Paper-Based Analytical Device for Thiamazole Detection by Hedysarum Polysaccharides-Mediated Silver Nanoparticles.

In this paper, silver nanoparticles (AgNPs) were successfully green-synthesized for the first time using Hedysarum polysaccharide (HPS) as a reducing agent, stabilizer, and modifier (HPS-AgNP). Thiamazole could induce the aggregation of HPS-AgNPs in the residue on a cellulose membrane. A syringe paper-based analytical device was creatively established to ensure the tightness, stability, and good repeatability of the test.

Sophorajaponica L. flower mediated carbon dots with nitrogen and sulfur co-doped as a sensitive fluorescent probe for amoxicillin detection.

This article first reported the green synthesis of N, S co-doped fluorescent carbon dots (N, S-CDs-Sop) and sought to establish the fluorescence detection system for amoxicillin (AMX). By using Sophorajaponica L. flower as the green precursor and dl-homocystine as the co-dopant, N, S-CDs-Sop were successfully prepared via a one-pot hydrothermal method, exhibiting good water solubility and excellent photoluminescence.

Removal of polybrominated diphenyl ethers in high impact polystyrene (HIPS) from waste TV sets.

Most studies have shown that improper disposal of e-waste can accelerate the release of high concentrations of polybrominated diphenyl ethers (PBDEs), and this situation causes environmental pollution and human health risks. The recycling technology of waste electronic plastics based on solvent processes can reduce environmental pollution and health risks from PBDEs. In this study, high impact polystyrene (HIPS) from waste TV sets was taken as the research object, and d-limonene and n-propanol were used as solvent and precipitant, respectively.

Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke.

Background: As a leading cause of death and disability, alternative therapies for stroke are still limited by its complicated pathophysiological manifestations. Guhong injection (GHI), consisting of safflower aqueous extract and aceglutamide, has been widely applied for the clinical treatment of cerebrovascular diseases, especially ischemic stroke and post-stroke recovery, in China. Recently, a series of studies have reported the positive effect of GHI against cerebral ischemia/reperfusion injury via targeting various molecular mechanisms.

Sequential aqueous acetone fractionation and characterization of Brauns native lignin separated from Chinese quince fruit.

Lignin, especially Brauns native lignin (BNL), from Chinese quince (Chaenomeles sinensis) fruit represents a potential source of natural antioxidants. However, the highly inhomogeneous structure and the carbohydrate impurity reduce the antioxidant properties of BNL. Accordingly, a sequential aqueous acetone fractionation was used to prepare pure lignin fractions with homogeneous molecular structures; these fractions showed strong antioxidant properties.