Benefit delayed immunosenescence by regulating CD4T cells: A promising therapeutic target for aging-related diseases.

CD4T cells play a notable role in immune protection at different stages of life. During aging, the interaction between the body's internal and external environment and CD4T cells results in a series of changes in the CD4T cells pool making it involved in immunosenescence. Many studies have extensively examined the subsets and functionality of CD4T cells within the immune system, highlighted their pivotal role in disease pathogenesis, progression, and therapeutic interventions.

Advances in cytokine-based herbal medicine against premature ovarian insufficiency: A review.

Ethnopharmacological Relevance: Premature ovarian insufficiency (POI) refers to a dramatic decrease in the number and/or quality of oocytes in the ovaries before the age of 40 years, and is a key cause of female infertility. The prevalence of POI has been increasing annually and tends to be younger. Researches on the etiology of POI and related pathogenesis are still very limited.

Role and mechanism of miRNA in cardiac microvascular endothelial cells in cardiovascular diseases.

The occurrence and development of myocardial dysfunction are associated with damage in the cardiac microvascular endothelial cells (CMECs), which can regulate nutrient exchange and oxy-gen-carbon cycling to protect cardiomyocytes. Interventions targeting microRNAs (miRNAs) can effectively mitigate CMEC injury and thus improve cardiovascular diseases. MiRNAs are a class of noncoding single-strand RNA molecules typically 21-23 nucleotides in length that are encoded by endogenous genes.

Shenxiang Suhe pill improves cardiac function through modulating gut microbiota and serum metabolites in rats after acute myocardial infarction.

Context: Shenxiang Suhe pill (SXSH), a traditional Chinese medicine, is clinically effective against coronary heart disease, but the mechanism of cardiac-protective function is unclear.

Objective: We investigated the cardiac-protective mechanism of SXSH modulating gut microbiota and metabolite profiles.

Materials And Methods: Sprague-Dawley (SD) male rats were randomly divided into 6 groups ( = 8): Sham, Model, SXSH (Low, 0.

polysaccharide attenuates lipopolysaccharide-induced lung injury in mice by regulating gut microbiota.

is appreciated for its edible and medicinal benefits especially for lung protection. However, the contained active components have been understudied, and further research is required to fully exploit its potential application. We aimed to probe into the beneficial effects of polysaccharide (POP) in lipopolysaccharide-induced lung inflammatory injury mice.

Remodeling of the gut microbiome by alleviates the development of acute myocardial infarction.

Introduction: The gut microbial community, which can be disturbed or repaired by changes in the internal environment, contributes to the development of acute myocardial infarction (AMI). Gut probiotics play a role in microbiome remodeling and nutritional intervention post-AMI. A newly isolated strain EU03 has shown potential as a probiotic.

Potential roles of gut microbes in biotransformation of natural products: An overview.

Natural products have been extensively applied in clinical practice, characterized by multi-component and multi-target, many pharmacodynamic substances, complex action mechanisms, and various physiological activities. For the oral administration of natural products, the gut microbiota and clinical efficacy are closely related, but this relationship remains unclear. Gut microbes play an important role in the transformation and utilization of natural products caused by the diversity of enzyme systems.

Identification of Drug-Induced Liver Injury Biomarkers from Multiple Microarrays Based on Machine Learning and Bioinformatics Analysis.

Drug-induced liver injury (DILI) is the most common adverse effect of numerous drugs and a leading cause of drug withdrawal from the market. In recent years, the incidence of DILI has increased. However, diagnosing DILI remains challenging because of the lack of specific biomarkers.

Therapeutic and Improving Function of Lactobacilli in the Prevention and Treatment of Cardiovascular-Related Diseases: A Novel Perspective From Gut Microbiota.

The occurrence and development of cardiovascular-related diseases are associated with structural and functional changes in gut microbiota (GM). The accumulation of beneficial gut commensals contributes to the improvement of cardiovascular-related diseases. The cardiovascular-related diseases that can be relieved by supplementation, including hypercholesterolemia, atherosclerosis, myocardial infarction, heart failure, type 2 diabetes mellitus, and obesity, have expanded.

leaf extract alters gut microbiota composition, enhances short-chain fatty acids production, and ameliorates osteoporosis in the senescence-accelerated mouse P6 (SAMP6) model.

The bark and the leaf of Oliv. content similar bioactive components, but the leaf of this medically important plant is mostly abandoned. In this study, we revealed that the aqueous extract of leaf (EUL) can promote the growth of the probiotic (LB) and inhibit the formation of osteoclast in vitro.