Publications by authors named "Xinqiao Chu"

Article Synopsis
  • Abnormal lipid metabolism has been connected to issues like intervertebral disc degeneration (IVDD), sciatica, and low back pain (LBP), prompting this study to explore whether lipid-lowering drugs can help prevent these conditions.
  • The research used genetic data and Mendelian randomization to investigate the impacts of specific drug targets (PCSK9, HMGCR, NPC1L1) on the development of IVDD, sciatica, and LBP, along with using data from the National Health and Nutrition Examination Survey (NHANES) to study LBP's connection to statin use.
  • Results showed that not using statins was linked to a higher risk of LBP, while reductions in total cholesterol
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Article Synopsis
  • The study evaluated the efficacy and safety of various biologic treatments for ulcerative colitis (UC), finding that vedolizumab had the highest effectiveness for both induction and maintenance therapy.
  • Guselkumab was noted for its low risk of recurrence and serious side effects, while ustekinumab showed the least risk for infections and serious adverse events.
  • Overall, the research provides insights for physicians in selecting the most effective and safe biologics for treating UC, addressing the challenges faced due to the numerous available treatment options.
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Objective: To observe the intervention of Chushizi (Fructus Broussonetiae) (CSZ) on drug-induced liver injury (DILI) in rats, as well as indicators of liver function, serum levels of inflammatory cytokines, and expression of proteins and mRNA associated with toll-like receptor 3 (TLR3) and the signal transducer and activator of transcription 3 (STAT3) pathway in the liver [TLR3, janus protein tyrosine kinase 2 (JAK2), c-jun, c-fos, c-Jun N-terminal kinase 2 (JNK2), and STAT3].

Methods: Forty specified pathogen free grade Sprague-Dawley rats were randomly divided into the control group, the model group, the silybin group and the CSZ group. Rats were given acetaminophen (APAP) to trigger DILI.

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Objective: To investigate the effect of Danggui Buxue Tang (DBT), a decoction from Traditional Chinese Medicine, on bleomycin-induced pulmonary fibrosis in rats, and to propose the possible underlying mechanism.

Methods: Forty male Sprague-Dawley rats were randomly divided into sham group, model group, prednisone group and DBT group. Pulmonary fibrosis rat model was established by intratracheal injection with bleomycin.

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