Searching for the novel tumour biomarkers is pressing for gastric cancer diagnostication and prognostication. The serum specimens from patients diagnosed with locally advanced gastric carcinoma before operation and 4 week after surgery were collected, respectively, and serum proteome profiling was conducted by liquid chromatography-mass spectrometry (MS)/MS. Fifty-five proteins were identified to be up-regulated and 16 proteins were down-regulated, and these differentially expressed proteins participated in various biological processes.
View Article and Find Full Text PDFTransl Cancer Res
April 2019
Background: The dysregulated long non-coding RNA (lncRNA) small nucleolar RNA host genes () have been demonstrated to be involved in gastric carcinogenesis and progression; however, the role of in gastric carcinoma remains to be investigated. We aimed to ascertain the expression of in gastric carcinoma tissues and cell lines, and to investigate its mechanistic role in this malignancy.
Methods: The expression levels of , , , , and cyclin dependent kinases-4 (CDK4) were determined by real-time quantitative polymerase chain reaction (RT-qPCR) and/or western blotting in human gastric cancer tissues and cell lines.