Synopsis of recent research by authors named "Xinpeng Wen"
- Xinpeng Wen's research primarily focuses on the mechanisms underlying cell fate transitions, particularly in mouse embryonic stem cells (mESCs), and how these transitions are regulated by specific transcription factors such as DUX and Zfp281.
- Recent findings reveal that the transition from pluripotent to totipotent states in mESCs is associated with cell death triggered by DUX-mediated DNA replication stress, shedding light on the challenges of maintaining totipotent cells in vitro.
- Additionally, Wen has contributed to understanding protein functionality in other biological models, such as the role of juvenile hormone in the phosphorylation of vitellogenin receptors in migratory locusts, and the creation of bacterial artificial chromosome libraries for plant genomics.
