A study on BOLD fMRI of the brain basic activities of MDD and the first-degree relatives.

The present study aims to explore the characteristics and differences of the ReHo, ALFF and fALFF of brain in the resting state of depression and first-degree relatives, in order to identify candidate central prodromal biomarkers of depression. Three groups of medication-free patients (39-59 years old) was involved in this study, including the patients with major depression disorder (MDD group,  = 15), healthy volunteers with first-degree relatives with MDD (first-degree relatives group,  = 15), healthy volunteers with no personal or family history of MDD (the control group [HC],  = 15). Participants underwent functional MRI while staying in a resting state after a conventional MRI scanning on a clinical 3 T system(Siemens Skyra, Germany).