Publications by authors named "Xinnian Pan"
Article Synopsis
- Congenital anomalies of the kidney and urinary tract (CAKUT) represent a range of genetic defects, but little is known about these conditions in newborns despite extensive research in older populations.
- This study analyzed clinical and whole exome sequencing data from 330 Chinese newborns with CAKUT, finding pathogenic genetic variants in 61 babies, predominantly affecting those with additional symptoms.
- The findings highlight the importance of genetic testing for CAKUT patients with extrarenal manifestations, as it can offer crucial insights for tailored clinical management and support, particularly for conditions like Kabuki syndrome and 17q12 deletion syndrome.
Article Synopsis
- Congenital auricular deformity (CAD) can occur alone or as part of a syndrome, and a study was conducted to explore genetic factors in critically ill neonates with CADs.
- The study enrolled 251 neonates, using next-generation sequencing (NGS), and found that 42.6% had genetic findings, primarily pathogenic variant types.
- Results showed that neonates with craniofacial or cardiovascular abnormalities were more likely to have genetic causes, and those diagnosed genetically had a higher mortality rate, emphasizing NGS's importance in understanding CAD in critically ill patients.
Importance: Neonatal seizures pose a significant challenge in critical care, and continuous video electroencephalography (cEEG) monitoring holds promise for early detection of seizures. However, large-scale data on the incidence of neonatal seizures and monitoring systems in China are lacking.
Objectives: To determine the incidence of neonatal seizures in infants with high risk in China.
Article Synopsis
- The study aimed to evaluate the clinical outcomes of preterm infants using non-invasive high-frequency oscillatory ventilation after extubation in a neonatal intensive care setting.
- A total of 149 preterm infants were randomly assigned to three different ventilation groups, and their respiratory and neurodevelopmental outcomes were measured at 12 and 24 months of age.
- Results showed no significant differences in respiratory issues, pulmonary function, or rates of neurodevelopmental impairment among the different ventilation methods, indicating similar effectiveness.
Aetiology and outcomes of prolonged neonatal jaundice in tertiary centres: data from the China Neonatal Genome Project.
Arch Dis Child Fetal Neonatal Ed
July 2022
Article Synopsis
- The study aimed to analyze the causes and outcomes of prolonged jaundice in newborns, specifically looking at those with jaundice lasting more than 14 days for term infants and 21 days for preterm infants.
- Out of 939 infants observed, 84.1% had identifiable causes for their jaundice, with genetic disorders being the most common cause in cases of prolonged conjugated hyperbilirubinaemia (PCHB).
- The findings suggest that genetic testing should be prioritized for infants with persistent jaundice, as it can alter clinical diagnoses and improve the management and outcomes of these patients.
Article Synopsis
- Congenital heart defects (CHDs) are the most common birth defects, and their genetic causes are complex and not fully understood; this study focuses on the genetic factors in CHD patients from neonatal intensive care units (NICUs).
- The research analyzed data from 1795 patients, finding that certain CHD types like atrial septal defects are prevalent, and that over a third had additional non-heart-related anomalies; 269 cases had identifiable genetic causes.
- The study, the largest of its kind in China, revealed that trio-whole-exome sequencing was more effective than clinical exome sequencing in identifying genetic diagnoses, and higher rates of genetic diagnosis were found among deceased patients compared to survivors, aiming to enhance future genetic
Objectives: To determine the diagnostic and clinical utility of trio-rapid genome sequencing in critically ill infants.
Design: In this prospective study, samples from critically ill infants were analyzed using both proband-only clinical exome sequencing and trio-rapid genome sequencing (proband and biological parents). The study occurred between April 2019 and December 2019.
Objective: To investigate the effectiveness and safety of non-invasive high-frequency oscillatory ventilation (NHFOV) in post-extubation preterm infants.
Methods: This was a randomized, controlled trial. A total of 149 preterm infants aged between 25 to 34 weeks' gestational age with a birth weight of <1500 g who required invasive mechanical ventilation on admission were included.
Article Synopsis
- * From December 2016 to December 2019, clinical exome sequencing was conducted on 588 neonates, leading to a 27.38% diagnostic rate, with the most common anomalies being cardiovascular malformations.
- * The study found that as the number of affected body systems increased, the likelihood of identifying a genetic cause also rose, suggesting that timely genetic testing could improve care for these patients.
Background: FLNC encodes actin-binding protein and is mainly concentrated in skeletal and cardiac muscle. Mutations in were found in cardiomyopathies. To date, studies on FLNC-cardiomyopathies have mainly been reported in adults.
View Article and Find Full Text PDFBackground: Necrotizing enterocolitis (NEC) is the leading cause of death among preterm infants born at < 30 weeks' gestation. The incidence of NEC is reduced when infants are fed human milk. However, in many neonatal intensive care units (NICUs), it is standard practice to freeze and/or pasteurize human milk, which deactivates bioactive components that may offer additional protective benefits.
View Article and Find Full Text PDFNeurodevelopmental outcomes of extremely preterm infants in southern China: A multicenter study.
Early Hum Dev
June 2019
Objective: To assess treatment outcomes and associated factors of extremely preterm infants (EPIs) in GuangXi, China.
Methods: This was a retrospective study consisting of 131 eligible cases with gestational age (GA) between 22 and 28 weeks, and infants were followed until 18-24 months. Data including clinical characteristics, perinatal factors and after-birth conditions were collected from the neonatal intensive care unit in 10 hospitals in Guangxi from January 1st 2010 until May 31st 2016.
[Follow-up observation of catch-up growth of preterm infants after discharge and risk factors for extrauterine growth retardation].
Zhongguo Dang Dai Er Ke Za Zhi
June 2018
Objective: To investigate the catch-up growth of preterm infants within a corrected age of 6 months and the risk factors for extrauterine growth retardation (EUGR).
Methods: A total of 321 preterm infants who were discharged after treatment in the neonatal intensive care unit and had regular follow-up documents with complete follow-up records were enrolled. According to the Prenatal Health Care Norms in 2015, these infants were divided into low-risk group with 69 infants and high-risk group with 252 infants.
Background: In developing countries, infant survival rate and long-term outcomes of extremely preterm infants(EPIs) have significantly improved due to advances in perinatal care. The striking gap in the treatment outcome of EPIs between China and the other developed countries was a major concern. To assess treatment outcomes and associated factors among EPIs in Nanning, China.
View Article and Find Full Text PDFObjective: To investigate the clinical value of humidified high-flow nasal cannula (HHFNC) as a respiratory support after extubation by comparing it with nasal continuous positive airway pressure (NCPAP) in neonates with meconium aspiration syndrome (MAS) and persistent pulmonary hypertension of the newborn (PPHN).
Methods: A total of 78 neonates with MAS and PPHN were randomly administered with HHFNC or NCPAP immediately after extubation. The following indices were compared between the two groups: blood gas parameters, duration of noninvasive ventilation, rate of extubation failure, and incidence of complications, such as nasal damage, abdominal distension, and intraventricular hemorrhage.
Article Synopsis
- * 744 neonates died in 26 NICUs, representing 1.2% of admissions, with preterm deaths being predominant (59.3%), largely due to pulmonary diseases and infections.
- * A significant number of deaths occurred after medical care was withdrawn, often due to parents' concerns about long-term outcomes, highlighting the need for better evaluation and communication regarding treatment options.
[Cellular and humoral immunity in preterm infants of different gestational ages].
Zhongguo Dang Dai Er Ke Za Zhi
November 2014
Objective: To investigate the characteristics of immune function in newborn infants of different gestational ages.
Methods: A total of 115 premature infants free of infection between June 1, 2012 and June 1, 2013 were divided into two groups according to their gestational age at birth: early preterm infant group (28-33+6 weeks, n=57) and late preterm infant group (34-36+6 weeks, n=58). Meanwhile, 88 full-term infants (37-41+6 week) were recruited to the control group.
[Influencing factors for severity of bronchopulmonary dysplasia in preterm infants].
Zhongguo Dang Dai Er Ke Za Zhi
October 2014
Objective: To explore the influencing factors for the severity of bronchopulmonary dysplasia (BPD) in preterm infants.
Methods: The clinical data of 110 preterm infants who were diagnosed with BPD and had a hospital stay of over 28 days between January 2011 and December 2013 were analyzed. These BPD infants were divided into 3 groups according to the clinical criteria: mild group (n=52), moderate group (n=44), and severe group (n=14).
[Efficacy of inhaled nitric oxide in premature infants with hypoxic respiratory failure].
Zhongguo Dang Dai Er Ke Za Zhi
August 2014
Objective: To investigate the safety and efficacy of low-concentration inhaled nitric oxide (NO) in the treatment of hypoxic respiratory failure (HRF) among premature infants.
Methods: Sixty premature infants (gestational age ≤ 34 weeks) with HRF were randomized into NO and control groups between 2012 and 2013, with 30 cases in each group. Both groups received nasal continuous positive airway pressure (nCPAP) or mechanical ventilation.
Objective: to prospectively validate a previously constructed transcutaneous bilirubin (TcB) nomogram for identifying severe hyperbilirubinemia in healthy Chinese term and late-preterm infants.
Methods: this was a multicenter study that included 9,174 healthy term and late-preterm infants in eight hospitals of China. TcB measurements were performed using a JM-103 bilirubinometer.
[Follow-up of auditory function in children with early congenital syphilis].
Zhongguo Dang Dai Er Ke Za Zhi
December 2008
[Relationship between hyperbilirubinemia and central nervous system damage in full-term neonates].
Zhongguo Dang Dai Er Ke Za Zhi
October 2006