Publications by authors named "Xinni He"
Hyperbranched polymers (HBPs) have drawn great interest in the biomedical field on account of their special morphology, low viscosity, self-regulation, and facile preparation methods. Moreover, their large intramolecular cavities, high biocompatibility, biodegradability, and targeting properties render them very suitable for anti-tumor drug delivery. Recently, exploiting the specific characteristics of the tumor microenvironment, a range of multifunctional HBPs responsive to the tumor microenvironment have emerged.
View Article and Find Full Text PDFPsoriasis is a prevalent relapsing dermatological condition that often necessitates lifelong treatment. The distinctive thickening of the stratum corneum presents a challenge to drug penetration. The employment of microneedles has been demonstrated to enhance the transdermal drug delivery efficacy by creating multiple microchannels in the skin.
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- Pomacea canaliculata is an invasive aquatic species with varying dietary habits and intestinal microbiota across different habitats (pond, river, ditch).
- This study utilized gene sequencing and metabolomics to analyze intestinal samples, revealing the highest dietary diversity in ditches and significant differences between male and female diets in ponds.
- The findings indicate that changes in diet affect intestinal microbiota and metabolic pathways, helping to explain how P. canaliculata adapts physiologically to diverse environments, which is crucial for understanding its impact on aquatic ecosystems.
The endogenous immunomodulator adenosine (ADO) was expected to be potentialized as an efficacious mediator to combat psoriasis. However, its efficacy is severely hindered by its poor metabolic stability and insufficient accumulation at the dermatological lesions. In this study, a biomineralized catalytic nanoreactor was delicately customized by encapsulating ADO precursor (adenosine monophosphate, AMP) within the internal porous skeleton of zeolitic imidazolate framework-90, followed by the biomineralization of the AMP catabolic enzyme on the outer layer.
View Article and Find Full Text PDFRoundup®, a prominent glyphosate-based herbicide (GBH), holds a significant position in the global market. However, studies of its effects on aquatic invertebrates, including molluscs are limited. Pomacea canaliculata, a large freshwater snail naturally thrives in agricultural environments where GBH is extensively employed.
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- Humans generate 350 million metric tons of plastic waste annually, causing significant microplastic pollution, particularly in aquatic environments and impacting aquatic organisms.
- This study investigated the effects of 80-nm polystyrene nanoplastics on the eggs and hatchlings of the Chinese soft-shelled turtle, revealing that the nanoplastics can penetrate eggshells and cause health issues such as a decreased heart rate in embryos, though they did not affect overall hatchling appearance or growth rate.
- The research showed a reduction in gut microbiome diversity in turtles exposed to nanoplastics, leading to an increase in harmful bacteria and a decrease in beneficial bacteria, which could affect turtle survival and population trends in the wild.
Nitrate and sodium nitroprusside alter the development of Asian black-spined toads' embryos by inducing nitric oxide production.
Environ Sci Pollut Res Int
February 2023
Nitrate is the most stable and abundant form of inorganic nitrogen in water. However, owing to human activities, the nitrate concentration in aquatic ecosystems has notably increased worldwide. One of the mechanisms underlying nitrate toxicity in vertebrates includes the functional inhibition of the sodium iodide symporter, resulting in thyroid dysfunction.
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