Background: Research interest into regulation of gene expression by physical activity and its effect on cancer prognosis has intensified. This study investigated the role of an exercise-related gene, , in the progression of non-small cell lung cancer (NSCLC) and its potential as therapy target.
Methods: Using the GSE41914 dataset, which includes data related to exercise, and the Cancer Genome Atlas (TCGA)-NSCLC dataset, we identified differentially expressed genes (DEGs) and selected as a hub gene for further analysis.
Based on the basic idea of expanding the interlayer spacing of MXene, utilizing the effect of gallic acid-modified cellulose nanofibers for rapid moisture separation, the flexible sensing and driving composite film with a perfect balance among humidity signal response and mechanical properties was prepared. Inspired by the stacking of autumn fallen leaves, the cellulose nanofibers-based composite films were formed by self-assembly under vacuum filtration of blending gallic acid-modified cellulose nanofibers with MXene. The enhanced mechanical properties (tensile strength 131.
View Article and Find Full Text PDFCircRNAs participates in the development and occurrence of multiple tumor types. However, the specific effects and underlying mechanisms of circRNA in intrahepatic cholangiocarcinoma (ICC) progression and recurrence remain poorly understood. CircRNA sequencing was performed to screen circRNAs related to ICC recurrence after surgery using 53 ICC frozen tumor specimens.
View Article and Find Full Text PDFBackground: Layilin (LAYN) represents a valuable prognostic biomarker across various tumor types, while also serving as an innovative indicator of dysfunctional or exhausted CD8 T cells and exhibiting correlation with immune context. However, the immune function and prognostic significance of LAYN in hepatocellular carcinoma (HCC) remain unexplored. Therefore, our objective is to investigate the role of LAYN in CD8 T cell exhaustion, clinical prognosis, and the tumor microenvironment within HCC.
View Article and Find Full Text PDFThe tumor-associated macrophages (TAMs) play multifaceted roles in the progression of hepatocellular carcinoma (HCC). However, the involvement of circular RNAs in the interplay between TAMs and HCC remains unclear. Based on Transwell co-culturing and circular RNA sequencing, this study revealed that TAMs enhanced tumor glycolysis and progression by upregulating circMRCKα in HCC cells.
View Article and Find Full Text PDFShape memory polymers (SMPs), as a type of smart materials, possess the unique shape memory and deformation recovery abilities. Hence, SMPs have been attracted extensive attentions and widely used in fields of electric devices, aerospace structures and biomedical engineering. Chitosan (CS), as a renewable natural biomass material, exhibits the excellent biocompatibility, biodegradability and antibacterial activities.
View Article and Find Full Text PDFACS Appl Mater Interfaces
November 2022
The direct coordination between polyhedral oligomeric silsesquioxane (POSS) and Co forms an assembly of nanoparticles with low specific surface area and leads to a poor dispersion state in the epoxy resin matrix, resulting in unsatisfactory flame-retardant efficiency. Metal-organic frameworks (MOFs), for instance, ZIF-67, provide not only the cobalt element but also the porous framework that endows the nanocomposite of MOFs and POSS with high specific surface area and abundant Co sites in the silica skeleton. Herein, ZIF-67 is hybridized with octacarboxyl POSS, resulting in the removal of the alkaline ligand to form novel metal POSS-organic frameworks (MPOFs).
View Article and Find Full Text PDFBackground: The human body has more than 600 kinds of skeletal muscles, which accounts for about 40% of the whole weight. Most skeletal muscles can make bones move, and their strength and endurance directly affect their performance during exercise.
Methods: To determine the effects of exercise and time on human skeletal muscle, we downloaded the microarray expression profile of GSE1832 and analyzed it to select differentially expressed genes (DEGs).
Background: Exercise is a regular behavioral activity that not only helps to lose weight but also reduces the risk of cardiovascular and cerebrovascular diseases. Diabetes is a common disease that plagues human health. It is shown that regular exercise can improve the insulin sensitivity of diabetic patients and have an important function in adjuvant therapy.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
April 2022
Conventional biometric modalities, such as the face, fingerprint, and iris, are vulnerable against imitation and circumvention. Accordingly, secure biometric modalities with cancelable properties are needed for personal identification, especially in smart healthcare applications. Here we developed a person identification model using high-density surface electromyography (HD-sEMG) as biometric traits.
View Article and Find Full Text PDFThe fatigue-induced neuromuscular mechanism remains to be fully elucidated. So far, the macroscopic mechanism using global surface electromyogram (sEMG) has been widely investigated. However, the microscopic mechanism using high-level neural information based on motor unit (MU) spike train from the spinal cord lacks attention, especially for the conditions under dynamic contraction task.
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
June 2021
We provide an open access dataset of High densitY Surface Electromyogram (HD-sEMG) Recordings (named "Hyser"), a toolbox for neural interface research, and benchmark results for pattern recognition and EMG-force applications. Data from 20 subjects were acquired twice per subject on different days following the same experimental paradigm. We acquired 256-channel HD-sEMG from forearm muscles during dexterous finger manipulations.
View Article and Find Full Text PDFMotor Control
November 2020
Surface electromyogram-based finger motion classification has shown its potential for prosthetic control. However, most current finger motion classification models are subject-specific, requiring calibration when applied to new subjects. Generalized subject-nonspecific models are essential for real-world applications.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
March 2021
The ability to expertly control different fingers contributes to hand dexterity during object manipulation in daily life activities. The macroscopic spatial patterns of muscle activations during finger movements using global surface electromyography (sEMG) have been widely researched. However, the spatial activation patterns of microscopic motor units (MUs) under different finger movements have not been well investigated.
View Article and Find Full Text PDFA sensitive detection electrode based on the composite of carbon nanotubes (CNTs) and polylactic acid (PLA) was fabricated for measuring the bioactive constituents in Belamcandae Rhizoma by capillary electrophoresis (CE). The composite was facilely fabricated by packing a blend of CNTs and melted PLA into a fused silica capillary under heat. The prepared CNT-PLA composite was characterized by scanning electron microscopy, Raman spectroscopy, Fourier transform infrared spectroscopy and cyclic voltammetry.
View Article and Find Full Text PDFJ Chromatogr B Analyt Technol Biomed Life Sci
December 2015
Serum uric acid (UA) concentration is positively associated with proteinuria. However, the relationship between proteinuria and urinary metabolites of purine metabolism remains unknown. This study developed a hydrophilic interaction chromatography (HILIC)-based HPLC method with ultraviolet detection (UV) to quantify creatinine (Cr), UA, xanthine, and hypoxanthine in human urine simultaneously.
View Article and Find Full Text PDFD-Glucaro-1,4-lactone (1,4-GL) has been shown to have a hypocholesterolemic effect in rats and human subjects. However, little information is known concerning the alteration of metabolome associated with the effect. Here, we show that 1,4-GL delays the development of hypercholesterolemia with the coadministration of a high-fat, high-cholesterol diet (HFHC) in rats.
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