Publications by authors named "Xinmin Ruan"
Resistant starch (RS) is beneficial for human health, and especially for diabetics. Considering the high cost and low productivity of the Jiangtangdao 1 rice variety with high RS content, breeding high RS rice varieties exhibiting high productivity is essential. A molecular marker-assisted selection strategy was applied to increase RS content in a three-line hybrid rice variety.
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- Pulmonary arterial hypertension (PAH) is a serious condition that can lead to high blood pressure in the lungs and right heart failure.
- 3,7-Bis(2-hydroxyethyl)icaritin (ICT), derived from icariin, shows promise in treating PAH by inhibiting phosphodiesterase type 5 (PDE5), which is linked to the disease's progression.
- A study on rats with monocrotaline-induced PAH revealed that ICT significantly reduced lung pressure and remodeling while boosting nitric oxide levels, suggesting it may be a more effective treatment than its predecessor, icariin.
Article Synopsis
- A clinical trial evaluated the effectiveness and safety of Huxin Formula in patients post-coronary artery bypass grafting (CABG) compared to a placebo over 12 months.
- While no significant differences were observed in primary outcomes like death or heart attacks, Huxin Formula showed positive effects on reducing angina symptoms after 90 days in patients with certain heart conditions.
- The study concluded that Huxin Formula may aid in improving heart function for patients with multiple vessel lesions and alleviate symptoms in some patients, but it did not demonstrate a clear advantage in key health outcomes.
Article Synopsis
- Percutaneous coronary intervention (PCI) is commonly used for treating coronary artery disease, but its effectiveness in reducing restenosis and improving quality of life has been limited.
- A clinical trial assessed the impact of the Huxin Formula, a modified Chinese medicine, on patients undergoing PCI, revealing no significant differences in primary outcomes between the treatment and control groups.
- However, patients with good ejection fractions and those with unstable angina reported better quality of life scores after using the Huxin Formula, with no serious side effects observed, suggesting it may be a safe option for certain patients post-PCI.
Article Synopsis
- The study aimed to investigate the impact of Huxin Formula (HXF) on gene expression related to cholesterol transport in ApoE knockout mice.
- Thirty ApoE (-/-) mice were divided into three groups and treated with HXF, pravachol, or saline after a high-fat diet, with key findings assessed through plaque size and gene expression analysis.
- Results showed that HXF significantly boosted caveolin-1 and SR-BI expression, leading to reduced aortic plaque formation, thereby suggesting its potential benefits in enhancing reverse cholesterol transport.
[Thinking of coronary heart disease treatment by integrative medicine].
Zhongguo Zhong Xi Yi Jie He Za Zhi
March 2011
Article Synopsis
- The study evaluates how C-reactive protein (CRP) levels affect the occurrence of in-stent restenosis after coronary procedures.
- A meta-analysis was conducted on 9 prospective studies involving 1,062 patients, showing that higher CRP levels were linked to a greater risk of restenosis.
- Results indicated a notable difference in CRP levels between patients with and without restenosis, particularly among those with unstable angina, while no significant correlation was found in stable angina patients.
Article Synopsis
- The study aimed to explore how volatile oils from Herba Pogostemonis and Exocarpium citri can be effectively included in Huxin Fang granules using beta-cyclodextrin.
- An orthogonal design method was employed, examining factors like the oil-to-beta-cyclodextrin ratio, water-to-beta-cyclodextrin ratio, and grinding time to optimize the inclusion process.
- The best inclusion conditions were found to be a 1:10 ratio of oil to beta-cyclodextrin, a 1:3 ratio of beta-cyclodextrin to water, and a grinding time of 40 minutes, confirming the feasibility of the approach.
[Systematic review of randomized controlled trials on preventing and treating restenosis after percutaneous coronary intervention with Chinese medicine].
Zhongguo Zhong Xi Yi Jie He Za Zhi
July 2008
Article Synopsis
- The study aimed to evaluate the effectiveness of Chinese medicine in preventing and treating restenosis after percutaneous coronary intervention (PCI) based on evidence-based medicine principles.
- The analysis included 17 studies, with only two being high-quality double-blinded trials, which showed that patients treated with Chinese medicine had significantly lower rates of restenosis and angina compared to the control group.
- Results indicated that Traditional Chinese Medicine (TCM) is effective in reducing the recurrence of restenosis and angina in patients post-PCI, although there may be some publication bias affecting the findings.
[Progress of study on applying traditional Chinese medicine and drugs in cardiac surgery].
Zhongguo Zhong Xi Yi Jie He Za Zhi
June 2008
Article Synopsis
- Traditional Chinese medicine and drugs have significantly advanced in cardiac surgery over the past decade.
- Progress includes improved treatment methods for conditions like coronary heart disease and myocardium protection.
- These advancements also enhance cardiopulmonary bypass procedures and help manage pulmonary hypertension.
[Effect of abdominal needling in treating post-cardiosurgical operational gastrointestinal dysfunction].
Zhongguo Zhong Xi Yi Jie He Za Zhi
April 2008
Article Synopsis
- The study aimed to assess the effectiveness of abdominal needling (AN) in improving gastrointestinal function after cardiac surgery.
- Sixty patients were divided into two groups: one received daily AN treatment while the other received standard intravenous medication with Omeprazole.
- Results showed that the AN group experienced significantly greater improvements in symptoms and gastric emptying rates compared to the control group, with notable differences in symptom scores and gastric motility.
[Cluster analysis on TCM syndromes in 319 coronary artery disease patients for establishment of syndrome diagnostic figure].
Zhongguo Zhong Xi Yi Jie He Za Zhi
July 2007
Article Synopsis
- The study aimed to investigate diagnostic criteria for Traditional Chinese Medicine (TCM) syndromes in patients with coronary heart disease (CHD).
- Researchers analyzed data from 319 CHD patients, using various statistical methods to identify characteristic symptoms associated with different TCM syndromes, such as qi deficiency and phlegm blockage.
- The findings suggest that establishing diagnostic figures for TCM syndromes can be based on clinical epidemiology, statistical analysis, and expert opinions, providing a reference for further research.
[Analysis on TCM syndrome distribution laws in 319 patients with coronary heart disease].
Zhongguo Zhong Xi Yi Jie He Za Zhi
June 2007
Article Synopsis
- The study aimed to investigate traditional Chinese medicine (TCM) syndrome distributions in patients with coronary heart disease (CHD) by conducting a clinical survey with 319 inpatients.
- Qi deficiency was identified as the most prevalent syndrome among CHD patients (87.1%), followed by blood stasis and phlegm retention syndromes, which were also significant (79.9% and 78.7% respectively).
- The research found that there was no notable difference in tongue and pulse characteristics related to specific coronary artery branches, and blood-lipid levels were similar across different TCM syndrome types, suggesting a common underlying pathogenesis centered on qi deficiency.
[Effects of shenfu injection on immune function in patients during perioperative cardiopulmonary bypass].
Zhongguo Zhong Xi Yi Jie He Za Zhi
September 2006
Article Synopsis
- The study aimed to assess the impact of Shenfu Injection (SI) on immune function in patients undergoing cardiopulmonary bypass (CPB).
- Ninety patients were divided into three groups (A, B, and C), with different timings for SI administration, and key immune markers were measured at various stages around the operation.
- Findings indicated that while leukocyte and neutrophil counts increased immediately after CPB, immune function metrics showed a decline, with groups A and B showing better recovery by the 8th post-operative day, suggesting SI may enhance immune responses and lower infection risks after surgery.
[Clinical efficacy of treatment for regulating Pi and protecting Xin in treating patients after coronary artery bypass grafting and its effect on patients' quality of life].
Zhongguo Zhong Xi Yi Jie He Za Zhi
January 2006
Article Synopsis
- The study evaluates the effectiveness of a traditional Chinese medicine treatment (CHM) combined with standard Western medicine in improving the quality of life for patients after coronary artery bypass grafting (CABG).
- After three months, patients receiving the CHM showed significant improvements in symptoms and heart function compared to those on conventional treatment alone.
- The findings suggest that the modified Huxin Recipe can enhance recovery and overall well-being in post-CABG patients.
Background: Patients with cyanotic congenital heart disease (C-CHD) usually have myocardial thickening and fibrosis, both of which can affect the course of surgical management. Hypoxia and ischemia may stimulate microvessel formation in the myocardium, which may accelerate the myocardial thickening and fibrosis. Whether hyperplasia of microvessels occurs in the myocardium of C-CHD was investigated in this report.
View Article and Find Full Text PDF[Clinical observation on quality of life in coronary artery bypass grafting patients treated according to syndrome differentiation of TCM].
Zhongguo Zhong Xi Yi Jie He Za Zhi
November 2003
Article Synopsis
- The study evaluated the clinical effects and quality of life in patients undergoing coronary artery bypass grafting (CABG) who were treated with Traditional Chinese Medicine (TCM) versus conventional Western medicine.
- After 2 months, patients receiving TCM showed better syndrome scores and higher Seattle Angina Questionnaire (SAQ) scores compared to those in the control group.
- TCM treatment significantly improved recovery, symptoms, and overall quality of life for CABG patients.