Exploring patient medication adherence and data mining methods in clinical big data: A contemporary review.

Background: Increasingly, patient medication adherence data are being consolidated from claims databases and electronic health records (EHRs). Such databases offer an indirect avenue to gauge medication adherence in our data-rich healthcare milieu. The surge in data accessibility, coupled with the pressing need for its conversion to actionable insights, has spotlighted data mining, with machine learning (ML) emerging as a pivotal technique.

Temporal lung changes on thin-section CT in patients with COVID-19 pneumonia.

We examined characteristics of chest CT across different time periods for patients with COVID-19 pneumonia in Huizhou, China. This study included 56 COVID-19 patients with abnormal CT acquired between January 22 and March 3, 2020. The 141 scans of 56 patients were classified into four groups (Groups 1-4) based on dates on which scans were obtained at the 1st, 2nd, 3rd week or longer than three weeks after illness onset.

Kangtaizhi Granule Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats and HepG2 Cells via AMPK/mTOR Signaling Pathway.

Kangtaizhi granule (KTZG) is a Chinese medicine compound prescription and has been proven to be effective in nonalcoholic fatty liver disease (NAFLD) treatment clinically. However, the underlying mechanisms under this efficacy are rather elusive. In the present study, network pharmacology and HPLC analysis were performed to identify the chemicals of KTZG and related target pathways for NAFLD treatment.

[A discussion on Zhang Cigong's materia medica].

Zhang Cigong's Materia Medica, being compiled by the author after learning and studying exogenous cold disease and herbology for several decades, printed in 1949 with a capacity of 150,000 Chinese characters, is a book of practical and clinical significance, featuring adoration on the theory of cold pathogenic disease, preferential practical use, integration of Chinese and western medicine, pursuit of origin and evolution, discussion on the compatibility of drug application. It emphasizes the application of drugs utilized in Shang han lun (Treatise on Cold Pathogenic Disease) and advocating the ideas of absorbing extensively ancient and modern theories from various schools, especially consulting the pharmacology of Chinese and the west, embodying the author's advocacy of "developing the classical ideas and integrating new knowledge", "overcoming one's weak points by learning from others' strong points and making effort in inheriting and developing the science of traditional Chinese medicine". However, this book also bears some incorrect points which are not overall and comprehensive enough in the understanding of drugs, and thus, should be properly accepted and rejected.