Bimetallic MOF derived electrocatalyst with magnetic alloy nanoparticles confined in S, N-doped carbon nanotubes: A disposable magnetic sensor for simultaneous determination of antibiotics in food.

Very few MOF-related derivatives have been applied for sensors. Sensitive analysis of antibiotics in food products is one of the crucial research fields. The work described the synthesis of magnetic electrocatalyst with FeCo alloy nanoparticles confined in S, N-doped bamboo-like carbon nanotubes (FeCo@S,N-CNTs) by using bimetallic MOF as precursor.

A renewable screen-printed electrode based on magnetic NiCo@N-doped carbon nanotubes derived from Co-MOF for ractopamine detection.

A renewable electrochemical screen-printed electrode (SPE) is proposed based on magnetic bamboo-like nitrogen-carbon (N-C) nanotubes loaded with nickel-cobalt alloy (NiCo) nanoparticles (NiCo@N-CNTs) for the determination of ractopamine (RAC). During the preparation of NiCo@N-CNTs, Co-MOF-67 (ZIF-67) was firstly synthesized, and then blended with dicyandiamide and nickel acetate, followed by a one-step pyrolysis procedure to prepare NiCo@N-doped carbon nanotubes. The surface morphology, structure, and chemical composition of NiCo@N-CNTs were characterized by SEM, TEM, XRD, XPS, and EDS.

Enhancement and inactivation effect of CRISPR/Cas12a via extending hairpin activators for detection of transcription factors.

An enhancement effect for the activation of CRISPR/Cas12a (CRISPR = clustered regularly interspaced short palindromic repeats; Cas = CRISPR-associated) was discovered. That was, a hairpin model with dangling 5' end complementary to crRNA (CRISPR RNA) greatly improved the activity of CRISPR/Cas12a after extention of two random sequences. But, the corresponding intact hairpin without PAM (protospacer adjacent motif) or suboptimal PAM sequences was completely inactive to CRISPR/Cas12a because of the superhigh stability of intact hairpin.

A dual-mode strategy based on β-galactosidase and target-induced DNA polymerase protection for transcription factor detection using colorimetry and a glucose meter.

In this work, we report a novel dual-mode method for the highly specific and sensitive detection of transcription factors (TFs) the integration of Klenow polymerase protection induced by target-specific recognition, cascade-signal amplification using the hybridization chain reaction (HCR) and CRISPR/Cas12a system, and dual-signal transduction mediated by β-galactosidase (β-gal) and two substrates. A dual-mode signal-sensing interface was constructed by immobilizing the oligo DNA probe (P1) tethered β-gal in a 96-well plate. A hairpin H1 with the ability to initiate HCRs was designed to contain the TF binding site.

The composite of bismuth oxyiodide-bismuth/nitrogen-doped carbon for photoreduction and electrochemical/photoelectrochemical dual-model sensing of Cr(VI).

A porous bismuth oxyiodide-metal bismuth/nitrogen-doped carbon (BiOI-Bi/N-C) composite composed of BiOI nanosheets, N-C sheets, and metallic Bi nanoparticles was prepared. BiOI-Bi/N-C exhibited remarkable cathodic photoelectrochemical activity and rapid adsorption capacity for Cr(VI) ions. Interestingly, the photocatalytic process of BiOI-Bi/N-C toward Cr(VI) was pH dependent.

Identification of miRNA/mRNA-Negative Regulation Pairs in Nasopharyngeal Carcinoma.

BACKGROUND Nasopharyngeal carcinoma (NPC) is a common malignancy in South-East Asia. NPC is characterized by distant metastasis and poor prognosis. The pathophysiological mechanism of nasopharyngeal carcinoma is unknown.