Stacking-dependent interlayer magnetic interactions in CrSe.

Recently, CrSe, a new ferromagnetic van der Waals two-dimensional material, was discovered to be highly stable under ambient conditions, making it an attractive candidate for fundamental research and potential device applications. Here, we study the interlayer interactions of bilayer CrSeusing first-principles calculations. We demonstrate that the interlayer interaction depends on the stacking structure.

Combined transcriptomics and metabolomics to analyse the response of Cuminum cyminum L. under Pb stress.

Lead (Pb) can disrupt plant gene expression, modify metabolite contents, and influence the growth of plants. Cuminum cyminum L. is highly adaptable to adversity, but molecular mechanism by which it responds to Pb stress is unknown.

Effects of plant growth-promoting rhizobacteria on blueberry growth and rhizosphere soil microenvironment.

Background: Plant growth-promoting rhizobacteria (PGPR) have a specific symbiotic relationship with plants and rhizosphere soil. The purpose of this study was to evaluate the effects of PGPR on blueberry plant growth, rhizospheric soil nutrients and the microbial community.

Methods: In this study, nine PGPR strains, belonging to the genera , were selected and added into the soil in which the blueberry cuttings were planted.

Machine learning classification of cellular states based on the impedance features derived from microfluidic single-cell impedance flow cytometry.

Mitosis is a crucial biological process where a parental cell undergoes precisely controlled functional phases and divides into two daughter cells. Some drugs can inhibit cell mitosis, for instance, the anti-cancer drugs interacting with the tumor cell proliferation and leading to mitosis arrest at a specific phase or cell death eventually. Combining machine learning with microfluidic impedance flow cytometry (IFC) offers a concise way for label-free and high-throughput classification of drug-treated cells at single-cell level.

The Efficient Energy Collection of an Autoregulatory Driving Arm Harvester in a Breeze Environment.

Breezes are a common source of renewable energy in the natural world. However, effectively harnessing breeze energy is challenging with conventional wind generators. These generators have a relatively high start-up wind speed requirement due to their large and steady rotational inertia.

Single-cell impedance cytometry of anticancer drug-treated tumor cells exhibiting mitotic arrest state to apoptosis using low-cost silver-PDMS microelectrodes.

Chemotherapeutic drugs such as paclitaxel and vinblastine interact with microtubules and thus induce complex cell states of mitosis arrest at the G/M phase followed by apoptosis dependent on drug exposure time and concentration. Microfluidic impedance cytometry (MIC), as a label-free and high-throughput technology for single-cell analysis, has been applied for viability assay of cancer cells post drug exposure at fixed time and dosage, yet verification of this technique for varied tumor cell states after anticancer drug treatment remains a challenge. Here we present a novel MIC device and for the first time perform impedance cytometry on carcinoma cells exhibiting progressive states of G/M arrest followed by apoptosis related to drug concentration and exposure time, after treatments with paclitaxel and vinblastine, respectively.

Dynamic Characteristics and Effective Stiffness Properties of Sandwich Panels with Hierarchical Hexagonal Honeycomb.

The dynamic characteristics of sandwich panels with a hierarchical hexagonal honeycomb (SP-HHHs) show significant improvements due to their distinct hierarchy configurations. However, this also increases the complexity of structural analysis. To address this issue, the variational asymptotic method was utilized to homogenize the unit cell of the SP-HHH and obtain the equivalent stiffness, establishing a two-dimensional equivalent plate model (2D-EPM).

Novel spiro[pyrrolidine-2,3'-quinoline]-2'-one derivatives containing piperazine fragment as potential chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation.

A series of spiro[pyrrolidine-2,3'-quinoline]-2'-one derivatives were designed and synthesized for the discovery of novel antifungal drugs. The bioactivities of all derivatives were screened by evaluating their inhibitory effects against chitin synthase (CHS) and antimicrobial activities in vitro. Enzyme inhibition experiments showed that all the synthesized compounds inhibited the chitin synthase.

A Harvester with a Helix S-Type Vertical Axis to Capture Random Breeze Energy Efficiently.

Breeze energy is a widely distributed renewable energy source in the natural world, but its efficient exploitation is very difficult. The conventional harvester with fixed arm length (HFA) has a relatively high start-up wind speed owing to its high and constant rotational inertia. Therefore, this paper proposes a harvester with a helix s-type vertical axis (HSVA) for achieving random energy capture in the natural breeze environment.

Design, synthesis and biological evaluation of novel spiro-quinazolinone derivatives as chitin synthase inhibitors and antifungal agents.

A series of spiro-quinazolinone scaffolds were constructed based on the bioactivity of quinazolinone and the inherent feature of spirocycle to design novel chitin synthase inhibitors that possess mode of action different from that of the currently used antifungal agents. Among them, the spiro[thiophen-quinazolin]-one derivatives containing α, β-unsaturated carbonyl fragments had shown inhibitory activities against chitin synthase and antifungal activities. The enzymatic experiments showed that among the sixteen compounds, compounds 12d, 12g, 12j, 12l and 12m exhibited inhibitions against chitin synthase with IC values of 116.

Investigating the Effective Performance of Sandwich Panel with Petal Star-Triangular Core Using VAM-Based Equivalent Model.

On the basis of star-shaped core sandwich panel, a novel sandwich panel with petal-triangle core (SP-PSC) was proposed to improve the negative Poisson's ratio (NPR) effect while retaining the characteristics of light weight and high strength. To study the complex structure more conveniently and quickly, a variational asymptotic method-based equivalent two-dimensional model (2D-EPM) was developed. The accuracy and efficiency of 2D-EPM were verified by the three-point bending experiment data and the 3D FE model results under different boundary and load conditions.

A VAM-Based Equivalent Model for Triangular Honeycomb Sandwich Panels: Comparison with Numerical and Experimental Data.

Due to their complex microstructures, the research on the static and dynamic behaviors of triangular honeycomb sandwich panels (triangular HSPs) is limited. In this study, the effective plate properties of triangular HSP was obtained by the homogenizing of the unit cell, and then the input to a VAM-based two-dimensional equivalent plate model (2D-EPM) to perform static and dynamic analyses. The accuracy of the proposed model for predicting the equivalent stiffness of the triangular HSP was verified by three-point bending experiments of 3D-printed specimens.

Semiconductor-Microbial Mechanism of Selective Dissolution of Chalcocite in Bioleaching.

Chalcocite-dominant secondary copper ore with a high pyrite content had a rapidly increased iron concentration in the middle and later periods of bioleaching, which increased the difficulty of separating copper and iron ions in the leaching solution. In the two aspects of microbial community succession and energy band theory, the selective dissolution mechanism of chalcocite in this type of copper ore was analyzed and illustrated using experiments and first-principles calculations. The results showed that controlling the solution potential at a lower level was beneficial to the selective leaching of chalcocite, while bacteria promoted the leaching of pyrite and chalcocite simultaneously by oxidizing Fe to Fe in the solution.

Shigella flexneri T3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-κB p65 protein.

Shigella species possess a type III secretion system (T3SS), which is required for human infection and that delivers effector proteins into target host cells. Here, we show that the effector, IpaH4.5 dampens the pro-inflammatory cytokine response.