Publications by authors named "Xinlong Du"
Article Synopsis
- Breast cancer patients often face treatment resistance due to chemoresistant breast cancer stem cells (BCSCs), which contribute to cancer recurrence and spread.
- Researchers developed an mRNA-based BCSC signature using machine learning to assess cancer stemness in patient samples and discovered that polyamine anabolism, influenced by the HIF-1 transcription factor, plays a crucial role in enhancing BCSC levels following chemotherapy.
- A natural compound, britannin, was found to inhibit HIF-1 activity, leading to reduced polyamine production and BCSC enrichment, suggesting a promising new approach for improving breast cancer treatment outcomes.
Article Synopsis
- The study focuses on a plant that thrives in zinc-rich mine tailings and exhibits high zinc tolerance while accumulating significant amounts of zinc.
- Seedlings were treated with zinc solutions for varying durations, leading to a comparative analysis of their genetic and protein expression in response to zinc exposure.
- Key findings indicate that specific genes and proteins related to zinc and iron transport were significantly upregulated, suggesting these mechanisms could inform approaches to genetically engineer and improve crop biofortification against nutrient deficiencies.
Article Synopsis
- Macleaya cordata shows potential for phytoremediation due to its high tolerance to heavy metals.
- The study analyzed the plant's response to lead (Pb) toxicity by examining differences in gene and protein expression before and after Pb treatment.
- Key findings include upregulated genes related to iron transport, downregulated calcium-binding proteins, and altered glutathione metabolism, indicating the plant's complex mechanisms to manage Pb accumulation and maintain cellular functions.
Heavy metal pollution possesses potential hazards to plant, animal and human health, which has become the focus of recent attention. Hence, phytoremediation has been regarded as one of the most important remediation technologies for heavy-metal-contaminated soils. In this research, a dominant mine tailing plant, , was used as the experimental material to compare the metal transport and oxidative stress response in its roots under lead (Pb) and zinc (Zn) treatments.
View Article and Find Full Text PDFConjugated polymers hold great promise for NIR-II fluorescence imaging (FI)-guided NIR-II photothermal therapy (PTT) due to the advantages of easy modification of chemical structures and adjustable NIR absorption. However, to make use of these advantages, it is of paramount importance to formulate conjugated polymers with excellent solubility in organic solution, great NIR-II photothermal conversion efficiency, and high NIR-II fluorescence quantum yield. Herein, a new class of conjugated/nonconjugated alternating copolymers (CNACPs) is reported by introducing nonconjugated linkers into a conjugated backbone to modulate the extinction coefficient at 1064 nm and NIR-II fluorescence quantum yield.
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