Publications by authors named "Xinling Wei"
Article Synopsis
- Hemifacial Spasm is a neurological disorder causing involuntary facial muscle spasms, mainly affecting quality of life, and can be categorized into primary and secondary types.
- Epidemiological data show it is more prevalent among women and older adults, often linked to vascular issues and specific gene expressions.
- Diagnosis involves MRI to identify nerve compression and white matter lesions, while treatment ranges from botulinum toxin injections to microvascular decompression, with additional alternative therapies available for severe cases.
We have presented an extensible, facile and sensitive multidimensional sensor based on DNA-gold nanoparticle (DNA-AuNP) conjugates for heavy metal ions (Ag(+), Hg(2+), Cr(3+), Sn(4+), Cd(2+), Cu(2+), Pb(2+), Zn(2+), and Mn(2+)) discrimination. In the presence of metal ions, the excluded effect of DNA and AuNPs with the same negative charges is disrupted, and the amount of FAM-labeled DNA adsorbed on AuNP surfaces increases, resulting in a more obvious fluorescence quenching effect. With the addition of NH2OH and HAuCl4, AuNPs grow into morphologically varied nanostructures (spherical to branched) depending on the resulting aptamer coverage, which gives rise to different colored solutions (reddish blush, purple and blue) observed by naked eyes.
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