Vague-Segment Technique: Automatic Computation of Tumor Stroma Ratio for Breast Cancer on Whole Slides.

The calculation of Tumor Stroma Ratio (TSR) is a challenging medical issue that could improve predictions of neoadjuvant chemotherapy benefits and patient prognoses. Although several studies on breast cancer and deep learning methods have achieved promising results, the drawbacks that pixel-level semantic segmentation processes could not extract core tumor regions containing both tumor pixels and stroma pixels make it difficult to accurately calculate TSR. In this paper, we propose a Vague-Segment Technique (VST) consisting of a designed SwinV2UNet module and a modified Suzuki algorithm.

Surface-up click access to allylimidazolium bridged cyclodextrin dimer phase for efficient enantioseparation.

In this work, a novel allylimidazolium-bridged bis(β-cyclodextrin) chiral stationary phase was fabricated via a surface-up thiol-ene click chemistry reaction between 7-SH-β-cyclodextrin and 1-allylimidazole-β-cyclodextrin bonded on a silica surface. The structure of the allylimidazolium-bridged bis(β-cyclodextrin) chiral stationary phase was characterized by Fourier transform infrared spectra, C nuclear magnetic resonance, thermogravimetric analysis, and elemental analysis. Its chiral chromatographic performances were systematically evaluated by separating 35 racemic analytes including isoxazolines, dansyl-amino acids, and flavanones under reversed-phase high-performance liquid chromatography.

Switchable Separation Strategy via Host-Guest Locks.

Universal separation strategies are the ultimate goal in separation science. However, there is always a tradeoff between universality and selectivity due to the negative influence among different recognition domains. With the goal of universal separation in mind, an unprecedented, switchable, and versatile separation strategy using reversible supramolecular host-guest interactions has been developed.

[Recent advances in the research of chromatographic separation materials based on click chemistry].

Since Nobel Laureate K. B. Sharpless first introduced the concept of click chemistry in 2001, such reactions have become a powerful modular synthesis tool.

Surface-up construction of quinine bridged functional cyclodextrin for single-column versatile enantioseparation.

Seeking for single-column versatile chiral separation methodology is the ultimate goal for analysts engrossed in enantioseparation. However, the versatility and selectivity are always contradictory due to negative influence among the recognition domains and the relatively low surface concentrations in a limited support surface area. Herein, we reported a novel series of quinine (QN) bridged cyclodextrin (CD) chiral stationary phases (CSPs) with satisfied surface concentration of both selectors, prepared via a facile surface-up 'thiol-ene click' approach, where QN and CD can not only nicely exhibit their individual resolution capability but also afford possible synergism in resolving difficult-to-separate analytes.

Click preparation of multiple-thioether bridged cyclodextrin chiral materials for efficient enantioseparation in high-performance liquid chromatography.

A highly efficient covalent immobilization procedure is considered as an essential tool for obtaining stable and reliable cyclodextrin (CD) chiral stationary phases (CSPs). This work reports the "thiolene" click immobilization of heptakis(6-mercapto-6-deoxy)-β-CD-CSP onto alkene functional silica to afford novel multiple-thioether bridged CD CSPs by controlling the surface CD concentration. Solid-state NMR, FTIR, TGA and X-ray photoelectron diffraction spectroscopy (XPS) results proved the successful preparation of the desired CSPs with different surface CD loadings.

A Case Study on Preoperative Acupuncture in Reducing the Risk of Operation.

The present study investigated the role of acupuncture as a pretreatment prior to surgery. The 72-y-old female was diagnosed with bilateral breast cancer and suffered from severe anxiety before the operation. The blood pressure of the patient was elevated due to anxiety.

Evaluation of the accumulation of disulfiram and its copper complex in A549 cells using mass spectrometry.

The famous alcohol-aversion drug disulfiram (DSF) is a promising candidate for repurposing in cancer therapy, as indicated by many ongoing and completed clinical trials. Existing researches focus on demonstrating that the anti-cancer activity of DSF is enhanced by copper ions, or solving the problem that DSF is easily decomposed in the body to lose its activity. However, the metabolic kinetics of its ultimate anti-cancer metabolite DDC-Cu (bis-diethyldithiocarbamate-copper) in cells and how it exerts anti-cancer mechanisms remain unclear.