Physiological and transcriptomic analysis reveal the regulation of adventitious root formation in Cinnamomum parthenoxylon cuttings.

Cinnamomum parthenoxylon is a significant essential oil plant in southern China, however, the challenge of rooting cuttings poses a hindrance to its development and widespread cultivation. Adventitious root (AR) formation is a vital mechanism for plants to acclimate to environmental changes, yet the precise regulatory mechanisms governing this process remain largely unknown. This study investigated the morphological, physiological, and transcriptomic alterations during AR formation in C.

Prevalence and characteristics of liver steatosis and fibrosis in type 2 diabetes mellitus (T2DM) patients: a cross-sectional study in populations of eastern China.

Objectives: To describe the prevalence, clinical characteristics and risk factors of liver steatosis and fibrosis in type 2 diabetes mellitus (T2DM) patients in eastern China.

Design: A cross-sectional, multicentre study based on an ongoing cohort study.

Setting: 16 clinics in eastern China, including primary clinics to tertiary hospitals.

Development and validation of a tumor marker-based model for the prediction of lung cancer: an analysis of a multicenter retrospective study in Shanghai, China.

Background: The incidence and mortality rates of cancer are the highest globally. Developing novel methodologies that precisely, safely, and economically differentiate between benign and malignant lung conditions holds immense clinical importance. This research seeks to construct a predictive model utilizing a combination of diverse biomarkers to effectively discriminate between benign and malignant lung diseases.

Developing a framework for identifying risk factors and estimating direct economic disease burden attributable to healthcare-associated infections: a case study of a Chinese Tuberculosis hospital.

Healthcare-associated infections (HAIs) represent a major global health burden, which necessitate effective frameworks to identify potential risk factors and estimate the corresponding direct economic disease burden. In this article, we proposed a framework designed to address these needs through a case study conducted in a Tuberculosis (TB) hospital in Hubei Province, China, using data from 2018 to 2019. A comprehensive multistep procedure was developed, including ethical application, participant inclusion, risk factor identification, and direct economic disease burden estimation.

Resection of unresectable hepatocellular carcinoma after conversion therapy with apatinib and camrelizumab: a case report and literature review.

Hepatocellular carcinoma is a rather common malignant tumor. Most patients with hepatocellular carcinoma receive their diagnosis at an advanced stage, at which surgical resection is no longer appropriate. A growing body of research has demonstrated the value of convention therapy for patients with intermediate-stage hepatocellular carcinoma, while specific application protocols and treatment guidelines are not well developed.

KYNU Expression Promotes Cisplatin Resistance in Esophageal Cancer.

Chemotherapy resistance is a barrier to effective cancer prognoses. Cisplatin (CDDP) resistance is a major challenge for esophageal cancer (EC) therapy. A deeper understanding of the fundamental mechanisms of cisplatin resistance and improved targeting strategies are required in clinical settings.

Radiation enteropathy-related depression: A neglectable course of disease by gut bacterial dysbiosis.

Radiation enteropathy (RE) is common in patients treated with radiotherapy for pelvic-abdominal cancers. Accumulating data indicate that gut commensal bacteria determine intestinal radiosensitivity. Radiotherapy can result in gut bacterial dysbiosis.

Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function.

Vaccines have been the primary remedy in the global fight against coronavirus disease 2019 (COVID-19). The receptor-binding domain (RBD) of the spike protein, a critical viral immunogen, is affected by the heterogeneity of its glycan structures and relatively low immunogenicity. Here, we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD, facilitating the elucidation of carbohydrate structure-function relationships.

Genome-wide identification and expression analysis of the glutamate receptor gene family in sweet potato and its two diploid relatives.

Plant glutamate receptor (GLR) homologs are crucial calcium channels that play an important role in plant development, signal transduction, and response to biotic and abiotic stresses. However, the gene family has not yet been thoroughly and systematically studied in sweet potato. In this study, a total of 37 genes were identified in the cultivated hexaploid sweet potato (), and 32 genes were discovered in each of the two diploid relatives ( and ) for the first time.

Chemical Synthesis Creates Single Glycoforms of the Ectodomain of Herpes Simplex Virus-1 Glycoprotein D.

Herpes simplex virus-1 (HSV-1) utilizes multiple viral surface glycoproteins to trigger virus entry and fusion. Among these glycoproteins, glycoprotein D (gD) functions as a receptor-binding protein, which makes it an attractive target for the development of vaccines against HSV-1 infection. Several recombinant gD subunit vaccines have been investigated in both preclinical and clinical phases with varying degrees of success.

Influence of landform, soil properties, soil Cd pollution and rainfall on the spatial variation of Cd in rice: Contribution and pathway models based on big data.

Landform, soil properties, soil cadmium (Cd) pollution and rainfall are the important factors affecting the spatial variation of rice Cd. In this study, we conducted big data mining and model analysis of 150,000 rice-soil sampling sites to examine the effects by the above four factors on the spatial variation of rice Cd in Hunan Province, China. Specifically, the variable coefficient of rice Cd in space was significantly correlated with the partition scale according to the logistic fitting.

is a Novel Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma.

Background: Lung adenocarcinoma (LUAD) is one of the most common and lethal cancer types worldwide. LINC0572 is a long non-coding RNA (lncRNA) that has been associated with the clinical characteristics of several types of malignancy. However, the biological mechanism of LINC0572 in LUAD is still unclear and remains to be elucidated.

A fungal-algal self-flocculation system and its application to treat filter sludge leachate in the sugar industry.

The efficient and economical treatment of wastewater using microalgae has attracted much attention. However, harvesting microalgae cells from treated wastewater remains challenging. In the present study, a Chlorella vulgaris suspension containing filamentous fungi Aspergillus niger and Chaetomium gracile was successfully used to construct a self-flocculating system, with a microalgae flocculation efficiency of 99.

Measuring Productivity and Relative Efficiency of Public Tertiary Traditional Chinese Medicine Hospitals in Hubei, China.

Improving the productivity and relative efficiency of traditional Chinese medicine (TCM) hospitals is pivotal for hospital managers and policymakers to optimize the utilization of TCM resources in China. This study aimed to measure the productivity and relative efficiency of public tertiary TCM hospitals in Hubei Province. The input and output indicators data were extracted from the Health Commission of Hubei Province (HCHP) from 2019 to 2021.

The critical role of biochar to mitigate the adverse impacts of drought and salinity stress in plants.

Drought stress (DS) is a potential abiotic stress that is substantially reducing crop productivity across the globe. Likewise, salinity stress (SS) is another serious abiotic stress that is also a major threat to global crop productivity. The rapid climate change increased the intensity of both stresses which pose a serious threat to global food security; therefore, it is urgently needed to tackle both stresses to ensure better crop production.

Variations in Essential Oils from the Leaves of in China.

plants are rich in natural essential oils, which are widely used as materials in the fragrance, insecticidal, antibacterial agent, pharmaceutical, and food industries; however, few studies have investigated the essential oil components of . Therefore, this study investigated the diversity of essential oils from the leaves of 885 individual plants across 32 populations in five provinces. Essential oils were extracted by hydrodistillation, and then qualitative and quantitative analyses of the compounds were performed by GC-MS and GC-FID.

Temporal fact extraction of fruit cultivation technologies based on deep learning.

There are great differences in fruit planting techniques due to different regional environments. Farmers can't use the same standard in growing fruit. Most of the information about fruit planting comes from the Internet, which is characterized by complexity and heterogeneous multi-source.

Targeted delivery of pexidartinib to tumor-associated macrophages via legumain-sensitive dual-coating nanoparticles for cancer immunotherapy.

Tumor-associated macrophage (TAM) is regarded as an appealing cell target for cancer immunotherapy. However, it remains challenging to selectively eliminate M2-like TAM in tumor microenvironment. In this work, we employed a legumain-sensitive dual-coating nanosystem (s-T-NPs) to deliver CSF-1R inhibitor pexidartinib (PLX3397) for targeting TAM therapy.

The impact of COVID-19 on global health journals: an analysis of impact factor and publication trends.

Background: COVID-19 has affected research productivity across all areas of knowledge. Current evidence suggests that COVID-19 has had a blockbuster effect on journal impact factors (JIFs) and publication trends, while little is known on global health journals.

Methods: Twenty global health journals were included to analyse the impact of COVID-19 on their JIFs and publication trends.

Chemical Variation and Environmental Influence on Essential Oil of .

is a traditional aromatic plant used to produce linalool and borneol flavors in southern China; however, its leaves also contain many other unutilized essential oils. Herein, we report geographic relationships for the yield and compositional diversity of essential oils. The essential oils of 974 individual trees from 35 populations in 13 provinces were extracted by hydrodistillation and analyzed qualitatively and quantitatively by gas chromatography-mass spectrometry and gas chromatography-flame ionization detection, respectively.

A novel knowledge extraction method based on deep learning in fruit domain.

Knowledge extraction aims to identify entities and extract relations between them from unstructured text, which are in the form of triplets. Analysis of the fruit nutrition domain corpus revealed many overlapping triplets, that is, multiple correspondences between a subject and multiple objects or the same subject and object. The current relevant methods mainly target the extraction of ordinary triplets, which cannot accurately identify overlapping triplets.