IL-6 Released from Hepatic Stellate Cells Promotes Glycolysis and Migration of HCC Through the JAK1/vWF/TGFB1 Axis.

Purpose: The crosstalk between hepatocellular carcinoma (HCC) cells and hepatic stellate cells (HSCs) is one of the important mechanisms of liver cancer metastasis. The relationship between liver cancer metastasis and glycolysis has been extensively studied recently. However, the role of von Willebrand factor (vWF) mediated glycolysis mechanism in liver cancer metastasis is currently unknown.

A Novel Approach to Evaluating Crosstalk for Near-Infrared Spectrometers.

Multi-channel and multi-parameter near-infrared spectroscopy (NIRS) has gradually become a new research direction and hot spot due to its ability to provide real-time, continuous, comprehensive indicators of multiple parameters. However, multi-channel and multi-parameter detection may lead to crosstalk between signals. There is still a lack of benchmarks for the evaluation of the reliability, sensitivity, stability and response consistency of the NIRS instruments.

An Enhanced Hidden Markov Map Matching Model for Floating Car Data.

The map matching (MM) model plays an important role in revising the locations of floating car data (FCD) on a digital map. However, most existing MM models have multiple shortcomings, such as a low matching accuracy for complex roads, long running times, an inability to take full advantage of historical FCD information, and challenges in maintaining the topological adjacency and obeying traffic rules. To address these issues, an enhanced hidden Markov map matching (EHMM) model is proposed by adopting explicit topological expressions, using historical FCD information and introducing traffic rules.

[Study on the transmission of drug resistant human immunodeficiency virus-1 in Henan province].

Objective: To survey the prevalence of HIV-1 drug resistance after five years antiretroviral treatment in Henan province.

Methods: Through the cross-sectional study, serum specimens of 69 HIV infected individuals that were 2 to 25 years old who were newly diagnosed according the WHO standard from November 2007 to August 2008 and did not receive antiretroviral treatment (ART) were collected. HIV-1 pol genetic mutations associated with drug resistance were identified with RT-PCR and interpreted.