Publications by authors named "Xinlian He"

Article Synopsis
  • A small molecule called NCA029 was identified as a potential treatment, demonstrating substantial effectiveness in relieving symptoms of colitis in both acute and chronic models, especially when administered orally.
  • NCA029 works by selectively binding to ClpP in CD4 T cells, reducing inflammation, restoring intestinal barrier function, and altering the balance of immune cells (Th17/Treg) through inhibition of oxidative phosphorylation.
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Dysregulation of signal transducer and activator of transcription 3 (STAT3) is implicated in the pathogenesis of various cancers, underscoring its potential as a cancer therapeutic target. In this work, we designed and synthesized a novel series of (E)-2-cyano-3-(4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-yl) derivatives and evaluated their anti-proliferative effects on tumour cells. Among these derivatives, NW16 exhibited remarkable antiproliferative activity against HCT116 cells, with an IC value of 0.

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Cytokines play a crucial role in the pathophysiology of autoimmune and inflammatory diseases, with over 50 cytokines undergoing signal transduction through the Signal Transducers and Activators of Transcription (STAT) signaling pathway. Recent studies have solidly confirmed the pivotal role of STATs in autoimmune and inflammatory diseases. Therefore, this review provides a detailed summary of the immunological functions of STATs, focusing on exploring their mechanisms in various autoimmune and inflammatory diseases.

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Diffuse alveolar hemorrhage (DAH) can be caused by various conditions, categorized as autoimmune and non-autoimmune. Immunofactor-mediated vasculitis, such as Wegener granulomatosis, microscopic polyangiitis, Goodpasture syndrome, connective tissue disorders, and antiphospholipid antibody syndrome, are common autoimmune causes. Non-autoimmune factors include infectious or toxic exposures and neoplastic conditions.

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The signal transducer and activator of transcription 3 (STAT3) has been established as a crucial drug target in the development of antitumor agents. In this study, a series of 21 derivatives of the STAT3 inhibitor napabucasin were designed and synthesized. Through preliminary screening against tumor cell lines, SZ6 emerged as the most potent compound with half maximal inhibitory concentration (IC) values of 46.

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Background: The increase in antimicrobial resistance leads to complications in treatments, prolonged hospitalization, and increased mortality. Glabridin (GLA) is a hydroxyisoflavan from Glycyrrhiza glabra L. that exhibits multiple pharmacological activities.

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Colorectal cancer (CRC) is trending to be a major health problem throughout the world. Therapeutics with dual modes of action have shown latent capacity to create ideal anti-tumor activity. Signal transducer and activator of transcription 3 (STAT3) has been proved to be a potential target for the development of anti-colon cancer drug.

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The high lethality of infections and the emergence of antibiotic resistance make the development of new antibiotics urgent. Our previous work identified a hit compound () as a novel () dihydrofolate reductase (DHFR) inhibitor. Herein, we analyzed the antimicrobial profile of and performed a comprehensive structure-activity relationship (SAR) assay based on .

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Article Synopsis
  • Inflammatory bowel disease (IBD) is a chronic illness that can lead to serious health risks, like colon cancer.
  • Researchers found a new compound called TAK875 that can block a protein called STAT3, which is involved in inflammation.
  • TAK875 showed promise in reducing inflammation and protecting cells in both lab studies and in mice, suggesting it could help treat IBD in the future.
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A novel class of quinoxaline-arylfuran derivatives were designed, synthesized, and preliminarily evaluated for their antiproliferative activities in vitro against several cancer cell lines and normal cells. The representative derivative exerts a potent antiproliferative effect against HeLa cells (IC value of 10.58 μM), through inducing apoptosis and triggering ROS generation and the accumulation of HeLa cells in vitro.

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A series of novel naphthoquinone-furan-2-cyanoacryloyl hybrids were designed; they were synthesized and preliminarily evaluated for their anti-proliferative activities in vitro against several cancer cell lines and normal cells. The most potent compound, , inhibited the proliferation of HeLa cells (IC value of 3.10 ± 0.

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Objective: To investigate the HbA(1c) proportion and mortality rate across diabetic patients with severe hypoglycemia and the risk factors for death.

Methods: All the diabetic patients with severe hypoglycemia were divided into HbA(1c)<6.5% group and HbA(1c)≥6.

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