Machine learning-aided understanding of the structure-activity relationship: a case study of MoS supported metal-nonmetal pairs for the hydrogen evolution reaction.

Understanding the structure-performance relationship is crucial for designing highly active electrocatalysts, yet this remains a challenge. Using MoS supported metal-nonmetal atom pairs (XTM@MoS, TM = Sc-Ni, and X = B, C, N, O, P, Se, Te, and S) for the hydrogen evolution reaction (HER) as an example, we successfully uncovered the structure-activity relationship with the help of density functional theory (DFT) calculations and integrated machine learning (ML) methods. An ML model based on random forest regression was used to predict the activity, and the trained model exhibited excellent performance with minimal error.

Neurotransmitters: Impressive regulators of tumor progression.

In contemporary times, tumors have emerged as the primary cause of mortality in the global population. Ongoing research has shed light on the significance of neurotransmitters in the regulation of tumors. It has been established that neurotransmitters play a pivotal role in tumor cell angiogenesis by triggering the transformation of stromal cells into tumor cells, modulating receptors on tumor stem cells, and even inducing immunosuppression.

Study on the Nanopore Deformation Mechanisms in Shale Oil Reservoir: Insights from the Molecular Simulation.

The stress and adsorption motivation deformation during shale oil production directly affect its development dynamics. First, a mathematical simulation of pore deformation in shale oil under stress motivation is established. We analyzed the impact of factors including the reservoir pressure, Biot coefficient, bulk modulus, and tortuosity on the deformation characteristics of nanopores.

Theoretical Exploration on the Role of Magnetic States to the N Fixation behaviors of 2D Transition Metal Tri-borides (TMB s).

Fixing nitrogen (N ) by electrosynthesis method has become a promising way to ammonia (NH ) production, nevertheless, developing electrocatalysts combining long-term stable and low-cost feathers are still a great challenge to date. Using comprehensive first-principles calculations, we herein investigate the potential of a new class of two-dimensional (2D) transition metal tri-borides (TMB s) as nitrogen reduction reaction (NRR) electrocatalysts, and explore the effect of magnetic orders on the NRR. Our results show that the TMB s can sufficiently activate N and convert it to NH .

Research on Characterization and Heterogeneity of Microscopic Pore Throat Structures in Tight Oil Reservoirs.

The key to the efficient development of a tight reservoir is its accurate evaluation. In this study, the pore throat structure characteristics of sandstone samples in the study block were analyzed by high-pressure mercury injection technology. According to the characteristics of the capillary pressure curve, the sandstone samples in the study block were divided into three types: the first type has a reservoir permeability greater than 0.

LncRNA LINC01410 Induced by MYC Accelerates Glioma Progression via Sponging miR-506-3p and Modulating NOTCH2 Expression to Motivate Notch Signaling Pathway.

Glioma is a common invasive cancer with unfavorable prognosis in patients. Long non-coding RNAs have been reported to participate in modulating diverse cellular processes. Here, we focused on exploring the role of long intergenic non-protein coding RNA 1410 (LINC01410) in glioma and its underlying mechanism.

miRNA-21 may serve as a promising noninvasive marker of glioma with a high diagnostic performance: a pooled analysis of 997 patients.

Background: Although various serum and tissue biomarkers have been investigated for glioma diagnosis, no gold standard has been identified. miRNA-21 was demonstrated to be a promising biomarker for the diagnosis of various brain tumors, whereas there remains uncertainty concerning whether miRNA-21 could be used as a good clinical diagnostic biomarker for glioma. The current meta-analysis aimed to evaluate the diagnostic accuracy of miRNA-21 as a potent biomarker in adults with suspected glioma.

miR-103a-3p alleviates oxidative stress, apoptosis, and immune disorder in oxygen-glucose deprivation-treated BV2 microglial cells and rats with cerebral ischemia-reperfusion injury by targeting high mobility group box 1.

Background: Cerebral ischemia-reperfusion injury (CI/R) is among the most common diseases affecting the central nervous system. Due to the poor efficacy and adverse side effects of the drugs used to treat CI/R in clinical trials, a new treatment strategy is urgently needed. In this study, we aimed to investigate whether miR-103a-3p alleviates CI/R and and to explore the relevant mechanisms.

Designed Single Atom Bifunctional Electrocatalysts for Overall Water Splitting: 3d Transition Metal Atoms Doped Borophene Nanosheets.

Single atom catalysts (SAC) for water splitting hold the promise of producing H in a highly efficient and economical way. As the performance of SACs depends on the interaction between the adsorbate atom and supporting substrate, developing more efficient SACs with suitable substrates is of significance. In this work, inspired by the successful fabrications of borophene in experiments, we systematically study the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER) activities of a series of 3d transition metal-based SACs supported by various borophene monolayers (BMs=α_sheet, α _sheet, and β _sheet borophene), TM/BMs, using density functional theory calculations and kinetic simulations.

[Overexpression of miR-382-5p Mediated Downregulation of PTEN on Malignant Biological Behavior of Human Glioma U251 Cells].

Objective: To investigate the effect of overexpression of miR-382-5p overexpression on malignant biological behavior of human glioma U251 cells.

Methods: U251 cells were transfected with miR-382-5pmimic. Then miR-382-5p and mRNA levels were detected by reverse transcription-polymerase chain reaction (RT-PCR) after transfection.

CREB1-induced miR-1204 promoted malignant phenotype of glioblastoma through targeting NR3C2.

Background: Glioblastoma (GBM) is a subclass of brain malignancy with unsatisfactory prognosis. MicroRNAs (miRNAs) are a group of non-coding RNAs (ncRNAs) that exert key function on tumorigenesis and tumor development.

Purposes: The purpose of this work was to unravel the biological behavior and mechanism of miR-1204 in GBM.

CBX3 promotes glioma U87 cell proliferation and predicts an unfavorable prognosis.

Background: Chromobox protein homolog 3 (CBX3) is one of the heterochromatin protein 1 (HP1) family members. Among multiple cancers, it is usually overexpressed. However, the mechanism and function of CBX3 in glioma remain incompletely illustrated.

Sizable bandgaps of graphene in 3d transition metal intercalated defective graphene/WSe heterostructures.

Controlling the electronic and magnetic properties of G/TMD (graphene on transition metal dichalcogenide) heterostructures is essential to develop electronic devices. Despite extensive studies in perfecting G/TMDs, most products have various defects due to the limitations of the fabrication techniques, and research investigating the performances of defective G/TMDs is scarce. Here, we conduct a comprehensive study of the effects of 3d transition metal (TM = Sc-Ni) atom-intercalated G/WSe heterostructures, as well as their defective configurations having single vacancies on graphene or WSe sublayers.

Investigating the Adoption of Mobile Health Services by Elderly Users: Trust Transfer Model and Survey Study.

Background: Although elderly users comprise a major user group in the field of mobile health (mHealth) services, their adoption rate of such services is relatively low compared with their use of traditional health services. Increasing the adoption rate of mHealth services among elderly users is beneficial to the aging process.

Objective: This study aimed to examine the determinants of mHealth service use intentions using a trust transfer model among elderly users facing declining physiological conditions and lacking support from hospitals.

Modulating the electronic and magnetic properties of bilayer borophene via transition metal atoms intercalation: from metal to half metal and semiconductor.

Borophene, a two-dimensional monolayer made of boron atoms, has attracted wide attention due to its appealing properties. Great efforts have been devoted to fine tuning its electronic and magnetic properties for desired applications. Herein, we theoretically investigate the versatile electronic and magnetic properties of bilayer borophene (BLB) intercalated by 3d transition metal (TM) atoms, TM@BLBs (TM = Ti-Fe), using ab initio calculations.

[Knockdown of STAT3 reduces the level of survivin and promotes the apoptosis of U87MG glioma cells].

Objective To investigate the effect of signal transducer and activator of transcription (STAT3)-specific siRNA (siSTAT3) on the apoptosis of U87MG human glioma cells and its mechanism. Methods U87MG glioma cells were cultured in vitro. The effect of siSTAT3 on U87MG human glioma cells was evaluated by MTT assay to observe cell proliferation and by flow cytometry and acridine orange staining to observe cell apoptosis.

[Expression and clinical significance of ING4 and HIF-1 alpha in brain astrocytoma].

Objective: To study the mRNA expression level of growth inhibition factor 4 (ING4) and hypoxia inducing factor 1 alpha (HIF-1 alpha), and their relationship with tumor malignant degree or the pathology classification in human brain astrocytoma.

Methods: The mRNA expression levels of ING4 and HIF-1 alpha were detected by RT-PCR method in 45 cases of grade I-IV human brain astrocytoma and 11 cases of control brain tissues from January 2009 to June 2010 in the Second Affiliated Hospital of Zhengzhou University, and their correlation was also analyzed.

Results: In the non-tumor brain tissue, the expression level of ING4 mRNA was 1.

Inhibitory effect of DNA topoisomerase inhibitor isoliquiritigenin on the growth of glioma cells.

Objective: To investigate the effect of isoliquiritigenin on the activity of DNA topoisomerase (TOP I) and its inhibitory effect on the growth of U87 glioma cells.

Methods: This study investigated the inhibitory effect of isoliquiritigenin on the growth of U87 glioma cells and its cytotoxicity by MTT method and determined the effect of isoliquiritigenin on TOP I activity by agarose gel electrophoresis. On this basis, we studied the interaction between isoliquiritigenin and TOP I and DNA.

Lack of genetic association of the TGM2 gene with schizophrenia in a Chinese population.

The gene coding for transglutaminase 2 (TGM2) has been reported to be associated with schizophrenia in a White population. The present study was then designed to replicate this initial finding in a Chinese population. A total of 428 individuals with schizophrenia and 555 control participants were recruited for genetic analysis.

PQ401, an IGF-1R inhibitor, induces apoptosis and inhibits growth, proliferation and migration of glioma cells.

Growth factor signalling pathways transduce extra-cellular physiological cues to guide cells to maintain critical cellular functions, including cell proliferation, survival and metabolism. Dysregulation of certain growth factor signalling pathways has been shown as a major route to promote tumourigenesis. Glioma is a type of aggressive malignant tumour with no effective systematic therapy so far.

Lack of genetic association between the MYO9B locus and schizophrenia in a Chinese population.

Jungerius et al. (2008) have reported that the myosin IXB (MYO9B) gene is strongly associated with susceptibility to schizophrenia in a Dutch population. However, this initial work failed to be replicated in a British population (Law et al.

[Effects of hippocampal stimulus on α₅ subunit of extrasynaptic GABA(A) receptor in kainic acid-induced epileptic rats].

Objective: To observe the effects of electrical hippocampal stimulation of α₅ subunit of extrasynaptic GABA(A) receptor in kainic acid-induced epileptic rats, explore the optimal therapeutic parameters and elucidate the possible mechanism of electrical stimulation for hippocampal epilepsy.

Methods: A total of 40 healthy male Sprague Dawley (SD) rats were randomly divided into 5 groups of epilepsy, sham operation, low-frequency stimulation (LFS), high-frequency stimulation (HFS) and normal control (n = 8 each). The expression of α₅ subunit of extrasynaptic GABA(A) receptor as well as the association with the curative effects of LFS were evaluated by behavioristics, real-time fluorogenic quantitative polymerase chain reaction (PCR) and Western blot.