Publications by authors named "Xinlei Huangfu"
Article Synopsis
- Direct synthesis of organophosphorus compounds from white phosphorus is crucial for improving the phosphorus chemical industry, especially concerning sustainability and safety.
- * China, as the largest producer of white phosphorus, drives the demand for the greener transformation of this vital material.
- * The review highlights Chinese research advancements in activating white phosphorus to form various chemical bonds and encourages further research in this area for future innovations.*
Organophosphorus compounds (OPCs) are widely used in many fields. However, traditional synthetic routes in the industry usually involve multistep and hazardous procedures. Therefore, it's of great significance to construct such compounds in an environmentally-friendly and facile way.
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- Organophosphorus compounds (OPCs) are important in organic synthesis, material science, and drug discovery, typically made from white phosphorus (P).
- Traditional methods for producing OPCs involve a complex and harmful chlorine route, raising environmental concerns.
- This study introduces a new, environmentally friendly method using visible light to directly benzylate phosphorus, utilizing benzyl bromide and improving the versatility of phosphorus functionalization through metallaphotoredox catalysis.
Developing practical and mild strategies for the direct functionalization of white phosphorus (P ) without chlorination is an appealing but formidable challenge. To this end, we report a breakthrough in the preparation of structurally diverse dialkylphosphines and trialkylphosphines that rely on the successive generation of carbon-centered radicals from N-hydroxyphthalimide (NHPI) esters and the controllable alkylation of the P molecule under transition-metal- and photocatalyst-free conditions. To facilitate separation and prevent product losses during purification, the corresponding oxidation products dialkylphosphine oxides (DAPOs) and trialkylphosphine oxides (TAPOs) were isolated.
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