Publications by authors named "Xinlei Deng"

Background: The potential for residential greenness to improve cardiovascular health through both physical and psychological mechanisms is well recognized. However, evidence from rapidly urbanizing developing countries and cohort-based causal inference approaches, remains limited. We aim to examine the effect of residential greenness and time to cardiovascular mortality in South China.

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Mental health effects are frequently reported following natural disasters. However, little is known about effects of living in a hazard-prone region on mental health. We analyzed data from 9,312 Gulf Long-term Follow-up Study participants who completed standardized mental health questionnaires including the Patient Health Questionnaire-9 (depression=score≥10), Generalized Anxiety Disorder Questionnaire-7 (anxiety=score≥10), and Primary Care PTSD Screen (PTSD=score≥3).

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Poor sleep quality is a widespread concern. While the influence of particle exposure on sleep disturbances has received considerable attention, research exploring other dimensions of sleep quality and the chemical components of the particles remains limited. We employed a marginal structural model to explore the association of long-term exposure to PM and its chemical components with poor sleep quality.

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Article Synopsis
  • The study focuses on predicting distant metastasis (DM) in patients with nasopharyngeal carcinoma (NPC) using detailed MRI reports, which is essential for improving treatment outcomes.
  • Researchers analyzed data from 792 non-distant metastatic NPC patients and identified 469 imaging variables to develop predictive models using gradient boosting tree (GBT) techniques.
  • The results showed that the GBT models, particularly those focusing on factors like the number of metastatic cervical nodes, had better predictive accuracy (AUC of 0.76) compared to the traditional tumor node-staging system (AUC of 0.67).
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Air pollution and greenness are environmental determinants of mental health, though existing evidence typically considers each exposure in isolation. We evaluated relationships between co-occurring air pollution and greenspace levels and depression and anxiety. We estimated cross-sectional associations among 9015 Gulf Long-term Follow-up Study participants living in the southeastern U.

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  • Long-term exposure to ambient fine particulate matter (PM) and its chemical components may increase the risk of nasopharyngeal carcinoma (NPC) recurrence, based on a study of 1,184 NPC patients over 10 years.
  • The research found a 33% increased risk of NPC recurrence for each interquartile range increase in PM exposure, with specific chemicals like black carbon (BC), organic matter (OM), and nitrates also linked to heightened risk.
  • Certain groups, including the elderly and those with no family cancer history or previous smoking/drinking habits, may be more vulnerable to NPC recurrence from PM exposure, suggesting a stronger relationship in high-concentration environments.
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  • The study investigates the link between solar radiation exposure and mood disorders like depression and distress in residents of U.S. Gulf states.
  • Researchers analyzed data from over 10,000 participants using specific screening questionnaires and matched it with solar radiation estimates based on their addresses.
  • Results indicated that higher solar radiation in the previous week was associated with lower rates of depression and distress, with seasonal variations also influencing these outcomes.
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Background: While limited studies have evaluated the health impacts of thunderstorms and power outages (POs) separately, few have assessed their joint effects. We aimed to investigate the individual and joint effects of both thunderstorms and POs on respiratory diseases, to identify disparities by demographics, and to examine the modifications and mediations by meteorological factors and air pollution.

Methods: Distributed lag nonlinear models were used to examine exposures during three periods (i.

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Introduction: Residential greenness may influence COPD mortality, but the causal links, risk trajectories, and mediation pathways between them remain poorly understood.

Objectives: We aim to comprehensively identify the potential causal links, characterize the dynamic progression of hospitalization or posthospital risk, and quantify mediation effects between greenness and COPD.

Methods: This study was conducted using a community-based cohort enrolling individuals aged ≥ 18 years in southern China from January 1, 2009 to December 31, 2015.

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Evidence of the potential causal links between long-term exposure to particulate matters (PM, i.e., PM, PM, and PM) and T2DM mortality based on large cohorts is limited.

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Exposure to particulate matter is associated with various adverse health outcomes. Ultrafine particles (UFPs; diameter <0.1 μm) are a unique public health challenge because of their size.

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Article Synopsis
  • - Urban greenness is important for combating urbanization's negative effects and promoting sustainability, but its link to lung cancer mortality has not been fully explored.
  • - A study involving 581,785 adults in southern China used a sophisticated statistical model to find that increased greenness is associated with lower lung cancer mortality (hazard ratio of 0.89 per IQR increase).
  • - The protective effects of urban greenness are partially due to lower levels of particulate matter, as well as its influence on temperature and physical activity, demonstrating a complex relationship that warrants further research.
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Background: The spatiotemporal and demographic disparities in exposure to ultrafine particles (UFP; number concentrations of particulate matter (PM) with diameter ≤0.1 μm), a key subcomponent of fine aerosols (PM; mass concentrations of PM ≤ 2.5 μm), have not been well studied.

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Introduction: Evidence on the interaction of lifestyle and long-term ambient particle (PM) exposure on the prevalence of hypertension, diabetes, particularly their combined condition is limited. We investigate the associations between PM and these outcomes and whether the associations were modified by various lifestyles.

Methods: This was a large population-based survey during 2019-2021 in Southern China.

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Background: Although power outage (PO) is one of the most important consequences of increasing weather extremes and the health impact of POs has been reported previously, studies on the neighborhood environment underlying the population vulnerability in such situations are limited. This study aimed to identify dominant neighborhood environmental predictors which modified the impact of POs on multiple health outcomes in New York State.

Methods: We applied a two-stage approach.

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Background: The association between long-term particulate matter (PM) exposure and all-cause mortality has been well-documented. However, evidence is still limited from high-exposed cohorts, especially for PM which is smaller while more toxic than other commonly investigated particles. We aimed to examine the potential casual links of long-term PMs exposure with all-cause mortality in high-exposed areas.

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Background: Evidence of the association between long-term exposure to particulate matter (PM) and chronic obstructive pulmonary disease (COPD) mortality from large population-based cohort study is limited and often suffers from residual confounding issues with traditional statistical methods. We hereby assessed the casual relationship between long-term PM (PM, PM and PM) exposure and COPD mortality in a large cohort of Chinese adults using state-of-the-art causal inference approaches.

Methods: A total of 580,757 participants in southern China were enrolled in a prospective cohort study from 2009 to 2015 and followed up until December 2020.

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Particulate matter (PM) pollution is a significant concern in public health, yet children's exposure is not adequately characterized. This study evaluated PM exposures among primary school-aged children in NYS across different microenvironments. This study helps fill existing knowledge gaps by characterizing PM exposure among this population across seasons and microenvironments.

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Rationale & Objective: Extreme heat exposure is associated with multiple diseases. However, our current understanding of the specific impact of extreme heat exposure on kidney disease is limited.

Study Design: Case-crossover study.

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Background: Previously, we found increased rates of ST-elevation myocardial infarction (STEMI) associated with increased ultrafine particle (UFP; <100 nm) concentrations in the previous few hours in Rochester, New York. Relative rates were higher after air quality policies and a recession reduced pollutant concentrations (2014-2016 versus 2005-2013), suggesting PM composition had changed and the same PM mass concentration had become more toxic. Tier 3 light duty vehicles, which should produce less primary organic aerosols and oxidizable gaseous compounds, likely making PM less toxic, were introduced in 2017.

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Background: Mental disorders (MDs) are behavioral or mental patterns that cause significant distress or impairment of personal functioning. Previously, temperature has been linked to MDs, but most studies suffered from exposure misclassification due to limited monitoring sites. We aimed to assess whether multiple meteorological factors could jointly trigger MD-related emergency department (ED) visits in warm season, using a highly dense weather monitoring system.

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While the health impacts of larger particulate matter, such as PM and PM, have been studied extensively, research regarding ultrafine particles (UFPs or PM) and particle surface area concentration (PSC) is lacking. This case-crossover study assessed the associations between exposure to PSC and UFP number concentration (UFPnc) and hospital admissions for cardiovascular diseases (CVDs) in New York State (NYS), 2013-2018. We used a time-stratified case-crossover design to compare the PSC and UFPnc levels between hospitalization days and control days (similar days without admissions) for each CVD case.

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We evaluated whether demographics and COVID-19 symptoms predicted COVID-19 deaths among healthcare workers (HCWs) in the United States by comparing COVID-19 deaths in HCWs with 3 control groups (HCW nondeaths, non-HCW deaths, and non-HCW nondeaths) using a case-control design. We obtained patient-level data of 33 variables reported during January 1, 2020-October 12, 2021, in all US states. We used logistic regression analysis while controlling for confounders.

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Although some studies tried to identify risk factors for COVID-19, the evidence comparing COVID-19 and community-acquired pneumonia (CAP) is inconclusive, and CAP is the most common pneumonia with similar symptoms as COVID-19. We conducted a case-control study with 35 routine-collected clinical indicators and demographic factors to identify predictors for COVID-19 with CAP as controls. We randomly split the dataset into a training set (70%) and testing set (30%).

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Background: Reducing the treatment gap for mental health in low- and middle-income countries is a high priority. Even with treatment, adherence to antipsychotics is rather low. Our integrated intervention package significantly improved medication adherence within 6 months for villagers with schizophrenia in resource-poor communities in rural China.

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