Publications by authors named "Xinkai Zheng"
The four matrine-derived alkaloids, namely sophflarines B-E (1-4), with distinct skeleton types, were isolated from Sophora flavescens. Compounds 1 and 2 possess rare 1-aza-11-oxatricyclo[5.3.
View Article and Find Full Text PDFBackground: There are few research findings on the survival prognosis of spindle cell melanoma (SCM), which is an unusual kind of melanoma. The purpose of this study was to develop a thorough nomogram for predicting the overall survival (OS) of patients with SCM and to assess its validity by comparing it with the conventional American Joint Committee on Cancer (AJCC) staging system.
Methods: The Surveillance, Epidemiology, and End Results database was searched, and 2,015 patients with SCM were selected for the analysis.
Analysis and prediction of 5-year survival in patients with cutaneous melanoma: a model-based period analysis.
Front Endocrinol (Lausanne)
December 2023
Article Synopsis
- Cutaneous melanoma (CM) is a serious skin cancer, and a study analyzed recent survival rates using data from the SEER database for the years 2004-2018 to understand patient outcomes better.
- The results revealed that the 5-year relative survival rates improved over the observed years, reaching 95.6% for the 2014-2018 period, with variations based on factors like age, gender, and race.
- The study predicts that this upward trend in survival rates will continue, estimating a 96.7% survival rate for 2019-2023, highlighting the importance of continuous assessment for better treatment and prevention strategies.
Background: For the purpose to examine lower limb melanoma (LLM) and its long-term survival rate, we used data from the Surveillance, Epidemiology and End Results (SEER) database. To estimate the prognosis of LLM patients and assess its efficacy, we used a powerful deep learning and neural network approach called DeepSurv.
Methods: We gathered data on those who had an LLM diagnosis between 2000 and 2019 from the SEER database.
Background: Increasingly, patient medication adherence data are being consolidated from claims databases and electronic health records (EHRs). Such databases offer an indirect avenue to gauge medication adherence in our data-rich healthcare milieu. The surge in data accessibility, coupled with the pressing need for its conversion to actionable insights, has spotlighted data mining, with machine learning (ML) emerging as a pivotal technique.
View Article and Find Full Text PDFProteomics analysis to investigate the potential mechanism of theacrine against UV-induced skin photodamage.
Photodermatol Photoimmunol Photomed
November 2023
Article Synopsis
- * Using proteomics, researchers identified key proteins and pathways involved in apoptosis that theacrine affects, showing it binds strongly to important apoptosis-related proteins.
- * Results suggest that theacrine decreases UV-induced skin cell death by regulating apoptosis signals, indicating its potential as an effective treatment for UVB skin damage.
Article Synopsis
- The study aims to find prognostic factors for keratinizing squamous cell carcinoma of the tongue (KTSCC) and create a nomogram to aid in patient diagnosis and treatment.
- Researchers analyzed data from 3,874 KTSCC patients using the SEER database, dividing them into training and validation groups, and employing Cox regression to identify key survival factors.
- A predictive model was developed, highlighting factors like age and tumor size, which improves survival rate predictions for KTSCC patients compared to existing AJCC methods.
Article Synopsis
- Ventilator-associated pneumonia (VAP) is a major and dangerous infection commonly found in intensive care units, and the length of antibiotic treatment is a key factor in patient prognosis.
- Research involving over 1,600 patients with VAP analyzed different durations of antibiotic use (<7 days, 7-10 days, >10 days) and their impact on mortality, revealing a nonlinear relationship between treatment duration and patient outcomes.
- Results indicated that both short (less than 7 days) and intermediate (7-10 days) antibiotic treatments increased the risk of adverse outcomes compared to longer treatments, highlighting the need for more research on the optimal duration for antibiotic use in VAP patients.
Dysregulation of autophagy-associated microRNAs in condyloma acuminatum.
Infect Genet Evol
September 2021
Condyloma acuminatum, which is caused by low-risk human papillomavirus (lrHPV) infection, is one of the most common sexually transmitted diseases. Autophagy is thought to be associated with condyloma acuminatum, but how the autophagy process is regulated remains unclear. MicroRNAs (miRNAs) are important regulators of gene transcription that play a central role in many biological processes, including autophagy and viral infection.
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