A preliminary exploration of establishing a mice model of hypoxic training.

Altitude training has been widely adopted. This study aimed to establish a mice model to determine the time point for achieving the best endurance at the lowland. C57BL/6 and BALB/c male mice were used to establish a mice model of hypoxic training with normoxic training mice, hypoxic mice, and normoxic mice as controls.

Enhanced photocatalytic performance in seawater of donor-acceptor type conjugated polymers through introduction of alkoxy groups in the side chain.

Previous studies have demonstrated that the donor (D)-acceptor (A) structure enables conjugated polymers (CPs) to effectively inhibit charge recombination, reduce exciton binding energy to a minimum, and broaden the light absorption spectrum, ultimately enhancing photocatalytic activity. Besides, side chain engineering is an effective approach to enhance photocatalytic performance by regulating surface chemistry and energy band structure of CPs. Herein, three D-A type CPs, namely TPD-T, TPD-MOT and TPD-DOT, were designed and synthesized using thieno[3,4-c]pyrrole-4,6-dione (TPD) as A units and thiophene with different alkyl/alkoxy groups side chain (as 3-octylthiophene (T), 3-methoxythiophene (MOT) and 3,4-ethylenedioxythiophene (DOT)) as D units, via an atom- and step-economic CH/CH cross-coupling polycondensation.

Neuroplasticity of visual brain network induced by hypoxia.

The effects of hypoxia on brain function remain largely unknown. This study aimed to clarify this issue by visual-stimulated functional magnetic resonance imaging design. Twenty-three college students with a 30-d high-altitude exposure were tested before, 1 week and 3 months after returning to sea level.

Upregulations of high mobility group box 1 and TLR4/NF-κB signaling pathway in hippocampus and serum of rats with febrile seizure.

Purpose: The aim of this study was to explore the alternations regarding the HMGB1 and TLR4/NF-B signaling pathway in juvenile rats with febrile seizure (FS).

Materials And Methods: During the animal modeling of the FS, seizures were triggered every four days by hot water (45 °C), and repeated ten times. After forty days' modeling, rats were divided into different groups according to the degree of seizure (FS (0) - FS (V)).

Case Report: A case of multisystem inflammatory syndrome in an 11-year-old female after COVID-19 inactivated vaccine.

Background: Multisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory, multisystem syndrome temporally associated with SARS-CoV-2, is a rare but serious complication of SARS-CoV-2 infection in children that typically occurs 2-6 weeks after SARS-CoV-2 infection. The pathophysiology of MIS-C is unknown. MIS-C, first recognized in April 2020, is characterized by fever, systemic inflammation, and multi-system organ involvement.

Brain Structural and Functional Alterations in Native Tibetans Living at High Altitude.

Tibetans have adapted to high altitude environments. However, the genetic effects in their brains have not been identified. Twenty-five native Tibetans living in Lhasa (3650 m) were recruited for comparison with 20 Han immigrants who originated from lowlands and had been living in Lhasa for two years.

Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants.

It has been well-established that high-altitude (HA) environments affect the human brain; however, the differences in brain structural and functional networks between HA natives and acclimatized immigrants have not been well clarified. In this study, native HA Tibetans were recruited for comparison with Han immigrants (average of 2.3 ± 0.

Severe pediatric Mycoplasma pneumonia as the cause of diffuse alveolar hemorrhage requiring veno-venous extracorporeal membrane oxygenation: A case report.

Background: Diffuse alveolar hemorrhage (DAH) is an acute life-threatening disease often associated with immunocompromised patients and systemic disorders, such as infections, vasculitis, and toxins. is one of the most common causes of community-acquired pneumonia in children, which rarely causes respiratory failure and fulminant disease; However, a rapid progression may occur in some patients. Mycoplasma pneumonia-associated DAH is rare.

T1ρ, T2 and T2* mapping of lumbar intervertebral disc degeneration: a comparison study.

Background: Early and accurate assessment of lumbar intervertebral disc degeneration (IVDD) is very important to therapeutic strategy. This study aims to correlate and compare the performances of T1ρ, T2 and T2* mapping for Pfirrmann grades and morphologic changes in the IVDD.

Methods: This prospective study included 39 subjects with 195 lumbar discs.

Attention Network Changes of High-Altitude Migrants.

The present study aimed to explore whether there are changes in the alerting, orienting, and executive network efficiencies of attention function between high altitude immigrants and low altitude residents. Event-related potentials (ERP) were acquired during an attention network test (ANT). The high-altitude (HA) group comprised 22 college student immigrants who were born and raised at low altitudes and had lived at a HA (11,975 ft/3650 m) for 26 mo (tests were conducted when they returned to HA for 3 mo).

The human brain in a high altitude natural environment: A review.

With the advancement of magnetic resonance imaging (MRI) technique, more detailed information about the human brain at high altitude (HA) has been revealed. The present review aimed to draw a conclusion regarding changes in the human brain in both unacclimatized and acclimatized states in a natural HA environment. Using multiple advanced analysis methods that based on MRI as well as electroencephalography, the modulations of brain gray and white matter morphology and the electrophysiological mechanisms underlying processing of cognitive activity have been explored in certain extent.

Resting-State Neuronal Activity and Functional Connectivity Changes in the Visual Cortex after High Altitude Exposure: A Longitudinal Study.

Damage to the visual cortex structures after high altitude exposure has been well clarified. However, changes in the neuronal activity and functional connectivity (FC) of the visual cortex after hypoxia/reoxygenation remain unclear. Twenty-three sea-level college students, who took part in 30 days of teaching at high altitude (4300 m), underwent routine blood tests, visual behavior tests, and magnetic resonance imaging scans before they went to high altitude (Test 1), 7 days after they returned to sea level (Test 2), as well as 3 months (Test 3) after they returned to sea level.

Pharmacokinetics and pharmacodynamic interaction of bergamottin with atorvastatin in rats.

1. The pharmacokinetics and pharmacodynamic of concomitant administration of atorvastatin with bergamottin were investigated perspectives to reveal the potential herb-drug interaction between these two drugs.2.

Evaluation of MRI Features and Neurodevelopmental Outcomes for Prenatally Diagnosed Periventricular Pseudocysts.

This study aimed to evaluate the morphologic features and neurodevelopmental outcomes of individuals prenatally diagnosed with a periventricular pseudocyst (PVPC). Pregnant women with a fetus prenatally diagnosed with PVPC by MRI were enrolled in this retrospective study. The fetuses with PVPCs were divided into group 1 (isolated PVPC) and group 2 (PVPC with additional findings).

Electrophysiological mechanisms underlying hypoxia-induced deficits in visual spatial and non-spatial discrimination.

Impaired visual cognition in residents of hypoxic environment has been widely reported; however, the underlying electrophysiological mechanisms remain unclear. In this study, 23 college students underwent three sessions of a Clock task test before a 30-day high-altitude exposure (Test 1) and 1 week (Test 2) and 3 months (Test 3) after they returned to lowlands. The Clock task consists of a visual spatial angle and a visual non-spatial color discrimination subtask.

Single-direction diffusion-weighted imaging may be a simple complementary sequence for evaluating fetal corpus callosum.

Objectives: To explore the feasibility of single-direction diffusion-weighted imaging (DWI) for assessing the fetal corpus callosum (CC).

Methods: This prospective study included 67 fetuses with normal CC and 35 fetuses suspected with agenesis of the corpus callosum (ACC). The MR protocols included HASTE, TrueFISP, and single-direction DWI.

Dopamine Imaging in Living Cells and Retina by Surface-Enhanced Raman Scattering Based on Functionalized Gold Nanoparticles.

Retinal dopamine is believed to be involved in the development of myopia, which is projected to affect almost half of the world population's visual health by 2050. Direct visualization of dopamine in the retina with high spatial precision is essential for understanding the biochemical mechanism during the development of myopia. However, there are very few approaches for the direct detection of dopamine in the visual system, particularly in the retina.

Exploring the impact of chronic high-altitude exposure on visual spatial attention using the ERP approach.

Introduction: Previous studies have reported the slowing of reaction times to attentionally demanding tasks due to a reduction in cognitive resource as a result of chronic high-altitude exposure. However, it is still largely unknown whether this reaction slowness can be attributed to the attentional allocation change and/or response patterns.

Methods: To clarify this issue, this study investigated attention-related (N2pc and N2 cc) and response-related (MP and RAP) event-related potentials (ERPs) to identify the performance of a visual search task by individuals who had lived in high-altitude areas for three years compared with those living at sea level.

Competition among the attentional networks due to resource reduction in Tibetan indigenous residents: evidence from event-related potentials.

This study used the attention network test (ANT) to evaluate the alerting, orienting, and executive network efficiencies of attention related to indigenous residents who were born and raised until early adulthood in different high-altitude areas (2900-m, 3700-m, and 4200-m) at the same location (3700-m) where these residents had been living for approximately 2 years in Tibet. We further applied the event-related potential (ERP) method to identify the underlying neurophysiological basis. Based on the ANT, we found that, in the 4200-m residents, executive function was increased but the orienting function was decreased, and the executive and orienting network scores were oppositely correlated.

An inflammatory myofibroblastic tumor in the transplanted liver displaying quick wash-in and wash-out on contrast-enhanced ultrasound: A case report.

Rationale: Inflammatory myofibroblastic tumor (IMT) is an uncommon mesenchymal neoplasm, and its presence in a grafted liver is exceedingly rare.

Patient Concerns: A 54-year-old woman was admitted to our hospital with a half-month history of intermittent melena. She had undergone deceased-donor liver transplantation (LT) for hepatitis B virus related liver cirrhosis without hepatocellular carcinoma 5 months previously.

[Focusing on MRI-suspected lesions in targeted transrectal prostate biopsy guided by MRI-TRUS fusion imaging for the diagnosis of prostate cancer].

Objective: To improve the accuracy of prostate cancer (PCa) detection by focusing biopsy on the suspected lesion manifested by MRI with the total number of biopsy cores relatively unchanged.

Methods: A prospective randomized analysis was performed on 262 cases of suspected PCa detected by multi-parametric MRI (mp-MRI), each with a single suspected lesion with 10 μg/L≤ PSA <20 μg/L. All the patients underwent targeted transrectal prostate biopsy guided by fusion imaging of MRI with transrectal ultrasonography (TRUS), using the 6X+6 strategy (6 cores in the suspected region and another 6 in the systematic prostate) for 134 cases and the traditional 12+2X method (12 cores in the systematic prostate and 2 in the suspected region) for the other 128.

Invasive placenta previa: Placental bulge with distorted uterine outline and uterine serosal hypervascularity at 1.5T MRI - useful features for differentiating placenta percreta from placenta accreta.

Objectives: To characterise MRI features of invasive placenta previa and to identify specific features for differentiating placenta percreta (PP) from placenta accreta (PA).

Methods: Forty-five women with PP and 93 women with PA who underwent 1.5T placental MRI were included.

Assessment of tibial and common peroneal nerves in diabetic peripheral neuropathy by diffusion tensor imaging: a case control study.

Objectives: To determine the diagnostic accuracy and interobserver performance of diffusion tensor imaging (DTI) in diabetic peripheral neuropathy (DPN) and detect correlations with electrophysiology.

Methods: Twelve healthy volunteers (controls) and ten DPN patients were enrolled to undergo MR examinations. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of tibial nerve (TN) and common peroneal nerve (CPN) were measured.

In vitro synergism of magnolol and honokiol in combination with antibacterial agents against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a problematic pathogen posing a serious therapeutic challenge in the clinic. It is often multidrug-resistant (MDR) to conventional classes of antibacterial agents and there is an urgent need to develop new agents or strategies for treatment. Magnolol (ML) and honokiol (HL) are two naturally occurring diallylbiphenols which have been reported to show inhibition of MRSA.