Indirubin-3'-monoxime exhibits potent antiviral and anti-inflammatory effects against human adenoviruses in vitro and in vivo.

Human adenovirus (HAdV) infection is a major cause of respiratory disease, yet no antiviral drugs have been approved for its treatment. Herein, we evaluated the antiviral and anti-inflammatory effects of cyclin-dependent protein kinase (CDK) inhibitor indirubin-3'-monoxime (IM) against HAdV infection in cells and a transgenic mouse model. After evaluating its cytotoxicity, cytopathic effect reduction, antiviral replication kinetics, and viral yield reduction assays were performed to assess the anti-HAdV activity of IM.

Associations of nirmatrelvir-ritonavir treatment with death and clinical improvement in hospitalized patients with COVID-19 during the Omicron wave in Beijing, China: a multicentre, retrospective cohort study.

Background: The effectiveness of nirmatrelvir-ritonavir has mainly been shown in non-hospitalized patients with mild-to-moderate coronavirus disease 2019 (COVID-19). The real-world effectiveness of nirmatrelvir-ritonavir urgently needs to be determined using representative in-hospital patients with COVID-19 during the Omicron wave of the pandemic.

Methods: We performed a multicentre, retrospective study in five Chinese PLA General Hospital medical centers in Beijing, China.

Real-world effectiveness of nirmatrelvir-ritonavir versus azvudine in hospitalized patients with COVID-19 during the omicron wave in Beijing: a multicenter retrospective cohort study.

Background And Aim: Two oral antivirals (Nirmatrelvir- ritonavir and Azvudine) are widely used in China practice during the Omicron wave of the pandemic. However, little evidence regarding the real-world effectiveness of these two oral antivirals in in-hospital patients. We aimed to evaluate the clinical effectiveness of nirmatrelvir-ritonavir versus azvudine among adult hospitalized patients with COVID-19.

iNOS inhibitor S-methylisothiourea alleviates smoke inhalation-induced acute lung injury by suppressing inflammation and macrophage infiltration.

Objective: We investigated the effects of the inducible NO synthase (iNOS) inhibitor, S-methylisothiourea (SMT), in a mouse model of smoke inhalation-induced acute lung injury (ALI) and explored the underlying molecular mechanism.

Methods And Analysis: A mouse model of smoke inhalation-induced ALI was established. RNA-sequencing (seq) analysis was conducted to identify the differentially expressed genes (DEGs).

Towards a photonic integrated all-optical phase regenerator.

All-optical phase regeneration aims at restoring the phase information of coherently encoded data signals directly in the optical domain so as to compensate for phase distortions caused by transceiver imperfections and nonlinear impairments along the transmission link. Although it was proposed two decades ago, all-optical phase regeneration has not been seen in realistic networks to date, mainly because this technique entails complex bulk modules and relies on high-precision phase sensitive nonlinear dynamics, both of which are adverse to field deployment. Here, we demonstrate a new, to the best of our knowledge, architecture to implement all-optical phase regeneration using integrated photonic devices.

Wavelength-division multiplexing communications using integrated soliton microcomb laser source.

In this Letter, we report an investigation of the feasibility and performance of wavelength-division multiplexed (WDM) optical communications using an integrated perfect soliton crystal as the multi-channel laser source. First, we confirm that perfect soliton crystals pumped directly by a distributed-feedback (DFB) laser self-injection locked to the host microcavity has sufficiently low frequency and amplitude noise to encode advanced data formats. Second, perfect soliton crystals are exploited to boost the power level of each microcomb line, so that it can be directly used for data modulation, excluding preamplification.

Comparisons of lymphocytes profiles and inflammatory cytokines levels in blood of patients with differed severity of infection by human adenovirus type 7.

Background: Human adenovirus (HAdV) infection outbreak causes community-acquired pneumonia. Cellular immune dysfunction and hypercytokinemia play important roles in the pathogenesis of adenovirus respiratory infection. Some soluble factors in peripheral blood can assist in judging the virus-induced disease severity.

Phase noise of Kerr soliton dual microcombs.

Dissipative Kerr soliton microcombs are believed to be a promising technique to build a dual-comb source for applications including precision laser metrology, fast laser spectroscopy, and high-speed optical signal processing. In this Letter, we conduct a detailed experimental investigation on the phase coherence between two on-chip Kerr soliton microcombs, where the underlying physical and technical origins that lead to the mutual phase noise between microcombs are analyzed. Moreover, the techniques of 2-point locking and optical frequency division are explored to enhance the dual-microcomb phase coherence, and we demonstrate the best phase noise down to -50 dBc/Hz at 1-Hz offset, -90 dBc/Hz at 1-kHz offset, and -120 dBc/Hz at 1-MHz offset.

Polarization multiplexed dissipative Kerr solitons in an on-chip micro-resonator.

We demonstrate polarization multiplexed dissipative Kerr solitons in an on-chip silicon nitride micro-resonator. In our experiment, TE- and TM-polarized solitons can be individually generated and controlled, thanks to their weak mutual interaction as the result of sufficiently different repetition rates and orthogonal polarization states. Furthermore, we find that TE- and TM-polarized solitons usually exhibit uncorrelated time jitters.

Coherent optical communications using coherence-cloned Kerr soliton microcombs.

Dissipative Kerr soliton microcombs have been recognized as a promising multi-wavelength laser source for fiber optical communications, as their comb lines possess frequency and phase stability far beyond the independent lasers. Especially, for coherent optical communications, a highly beneficial but rarely explored target is to re-generate a Kerr soliton microcomb as the receiver local oscillators that conserve the frequency and phase property of the incoming data carriers, so that to enable coherent detection with minimized optical and electrical compensations. Here, via pump laser conveying and two-point locking, we implement re-generation of a Kerr soliton microcomb that faithfully clones the frequency and phase of another microcomb sent from 50 km away.

Research on a Dual-Mode Infrared Liquid-Crystal Device for Simultaneous Electrically Adjusted Filtering and Zooming.

A new dual-mode liquid-crystal (LC) micro-device constructed by incorporating a Fabry⁻Perot (FP) cavity and an arrayed LC micro-lens for performing simultaneous electrically adjusted filtering and zooming in infrared wavelength range is presented in this paper. The main micro-structure is a micro-cavity consisting of two parallel zinc selenide (ZnSe) substrates that are pre-coated with ~20-nm aluminum (Al) layers which served as their high-reflection films and electrodes. In particular, the top electrode of the device is patterned by 44 × 38 circular micro-holes of 120 μm diameter, which also means a 44 × 38 micro-lens array.