Identification of polyamine metabolism-related prognostic biomarkers for predicting breast cancer prognosis, immune microenvironment, and candidate drugs.

In this study, polyamine metabolism related genes (PMRGs) were used to establish a breast cancer (BC) prognostic model. Using PMRGs, TCGA BC samples were divided into cluster1 and cluster2. A 13-gene BC prognostic model was constructed by screening differential genes.

Mediating Role of Viral Anxiety and Insomnia in Relationship Between Work-Related Stress and Depression Among Cold Chain Workers During COVID-19 Pandemic.

Background: Here we investigated whether cold chain workers' insomnia, work-related stress, and viral anxiety contributed to their depression. Furthermore, we investigated the role of viral anxiety in mediating the association between work-related stress and depressive symptoms.

Methods: All 200 invited cold chain workers voluntarily responded to an online survey.

Identification of SAA1 as a novel metastasis marker in ovarian cancer and development of a graphene-based detection platform for early assessment.

Background: Ovarian cancer (OC) is a prevalent gynecological malignancy with the highest mortality rate, which generally diagnosed at late stages due to the lack of effective early screening methods and the nonspecific symptoms. Hence, here we aim to identify new metastasis markers and develop a novel detection method with the characteristics of high sensitivity, rapid detection, high specificity, and low cost when compared with other conventional detection technologies.

Methods: Blood from OC patients with or without metastasis were collected and analyzed by 4D Label free LC - MS/MS.

Construction and validation of a metabolism-related prognostic model for thyroid cancer.

Metabolic reprogramming is a common pathological process of cancer. Expression of metabolism-related genes differs in thyroid cancer (TC) patients with different prognoses. This work committed to constructing a prognostic model for TC through identifying metabolism-related signatures.

Application of Stress and Anxiety to Viral Epidemics-6 to Measure the Anxiety Response of Cold Chain Practitioners During the COVID-19 Post-Pandemic Era in China.

Objective: This study explored the psychometric properties of the Chinese version of the Stress and Anxiety to Viral Epidemics-6 Items (SAVE-6) scale for cold chain practitioners exposed to moderate-to-high risk of infection.

Methods: A total of 233 cold chain practitioners participated in an anonymous online survey, conducted from October to November 2021. The questionnaire comprised participant demographic characteristics, the Chinese version of SAVE-6, the Generalized Anxiety Disorders-7 (GAD-7), and the Patient Health Questionnaire-9 (PHQ-9) scales.

Identification and validation of a five-gene prognostic signature based on bioinformatics analyses in breast cancer.

Background: This study aimed to identify prognostic signatures to predict the prognosis of breast cancer (BRCA) patients based on a series of comprehensive analyses of gene expression data.

Methods: The RNA-sequencing expression data and corresponding BRCA patient clinical data were collected from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) datasets. Firstly, the differently expressed genes (DEGs) related to prognosis between tumor tissues and normal tissues were ascertained by performing R package "limma".

Carbothermal redox reaction in constructing defective carbon as superior oxygen reduction catalysts.

Defects can greatly promote the catalytic activity of a carbon-based electrocatalyst due to charge redistribution of its electroneutral π-conjugated structure. However, it is still a huge challenge to introduce enough defects into carbon-based materials to improve their catalytic activity. Herein, we report a new method for defect generation by the pyrolysis of the sulfur-nitrogen-containing coordination polymer [Zn(ptt)] (ptt = 1-phenyl-1-tetrazole-5-thiol).

[BaCl] Cations Directed Perovskite-like Polar Metal Formate Frameworks {[BaCl][M(HCO)]} (M = Mn, Co, and Mg): Microwave-Assisted Synthesis, Structures, and Properties.

Novel 3D metal formate frameworks {[BaCl][M(HCO)]} (M = Mn for , Co for , and Mg for ) were successfully assembled via microwave-assisted synthesis. The complexes are rare coordination polymers crystallized at space group 4 with the polar point group . In the structure, the M ions are bridged by two types of - formate in forming a 3D framework, and additional formates coordinate to the unsaturated sites of the M ions in the framework, giving an anionic M-formate net.

Neoadjuvant chemotherapy combined with interval cytoreductive surgery in ovarian cancer.

Purpose: This study aimed to explore the value and prognosis-influencing factors for neoadjuvant chemotherapy combined with interval cytoreductive surgery in patients with advanced ovarian cancer.

Methods: 178 patients were divided into the research group and control group. The research group was treated with neoadjuvant chemotherapy combined with interval cytoreductive surgery, while the control group underwent primary cytoreductive surgery alone.

MicroRNA-409-3p inhibits osteosarcoma cell migration and invasion by targeting catenin-δ1.

Osteosarcoma is the most common primary bone cancer which is associated with early metastatic potential and poor prognosis. However, the molecular mechanisms underlying osteosarcoma progression are not well characterized. Here, we investigated the role of miR-409-3p in osteosarcoma metastasis.

Body Mass Index May Positively Correlate with Bone Mineral Density of Lumbar Vertebra and Femoral Neck in Postmenopausal Females.

Background: Our study aimed to explore the relationship between body mass index (BMI) and bone mineral density (BMD) of lumbar vertebra and femoral neck in postmenopausal females.

Material/methods: From September 2012 to September 2014, 236 healthy postmenopausal females who underwent physical examinations at the Women & Children's Health Care Hospital of Linyi were enrolled into our study. These subjects were divided into 3 groups: underweight group, normal weight group, and overweight group.

microRNA-195 inhibits the proliferation, migration and invasion of cervical cancer cells via the inhibition of CCND2 and MYB expression.

The functions of microRNAs (miRNA/miR) in the development of cervical cancer remain largely undefined. The present study investigated the role of miR-195 in cervical cancer development. The expression of miR-195 mimics in the cervical cancer HeLa cell line significantly decreased the cell proliferation, migration and invasion capacities .